Abstract
Ionizing radiation causes destruction of mammalian tissue by two mechanisms (Kinzie et al, 1972): (1) inhibition of the proliferative capacity of rapidly dividing cells, and (2) irreversible damage to elements of the microcirculatory system. Organs such as liver, kidney and brain, not characterized by rapidly proliferating cells, exhibit a relatively pronounced radio-sensitivity in spite of a very slow rate of cellular turnover. The radiosensitivity of the microcirculation could provide the reason for the radiosensitivity of the entire organ or tissue.
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© 1978 Plenum Press, New York
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Bicher, H.I., D’Agostino, L., Doss, L.L., Kaufman, N., Amigone, J. (1978). Prevention of Ionizing Radiation-Induced Liver Microcirculation Changes by the Use of Flow Improvers. In: Silver, I.A., Erecińska, M., Bicher, H.I. (eds) Oxygen Transport to Tissue — III. Advances in Experimental Medicine and Biology, vol 94. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8890-6_50
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DOI: https://doi.org/10.1007/978-1-4684-8890-6_50
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