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Diversity of Novel Proteins in Gonadal Fluids

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Molecular Biology of Brain and Endocrine Peptidergic Systems

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Bovine seminal plasma contains four similar acidic proteins that we have previously designated as BSP-A1, BSP-A2, BSP-A3 and BSP-30kDa. These proteins, when added to pituitary cells grown in synthetic medium, result in an immediate release of gonadotropins in a manner similar to LH-RH. In lower concentrations they antagonize the action of LH-RH. BSP-A1, -A2 and -A3 have molecular weights between 15,000–16,000, while BSP-30kDa has a molecular weight of 30,000. BSP-A1, -A2 and -30kDa are glycoproteins containing neutral sugars, galactosamine and sialic acid. BSP-A1 and -A2 appear to be molecular variants that contain different amounts of carbohydrate but have an identical amino acid composition. BSP-A3 and -30kDa each has an amino acid composition different from that of -Al and -A2. BSP-A1/-A2 and -A3 each contain two similar domains that are arranged in tandem fashion and are homologous to the gelatin-binding domain of fibronectin as well as the amino-terminal end of human factor XII (blood clotting and fibrinolytic protease).

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Author information

Authors and Affiliations

  1. Endocrine Laboratory, Maisonneuve-Rosemont Hospital Research Center and Department of Medicine, University of Montreal, Canada

    P. Manjunath, L. Baillargeon & A. Chapdelaine

  2. Laboratories of Lipoprotein Metabolism, Clinical Research Institute of Montreal, Canada

    Y. L. Marcel

  3. Laboratories of Biochemical, Clinical Research Institute of Montreal, Canada

    N. G. Seidah

  4. Laboratories of Molecular Neuroendocrinology, Clinical Research Institute of Montreal, Canada

    M. Chrétien

Authors
  1. P. Manjunath
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  2. L. Baillargeon
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  3. Y. L. Marcel
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  4. N. G. Seidah
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  5. M. Chrétien
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  6. A. Chapdelaine
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Editor information

Editors and Affiliations

  1. Clinical Research Institute, Montreal, Quebec, Canada

    Michel Chrétien

  2. International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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© 1988 Plenum Press, New York

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Manjunath, P., Baillargeon, L., Marcel, Y.L., Seidah, N.G., Chrétien, M., Chapdelaine, A. (1988). Diversity of Novel Proteins in Gonadal Fluids. In: Chrétien, M., McKerns, K.W. (eds) Molecular Biology of Brain and Endocrine Peptidergic Systems. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8801-2_17

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  • DOI: https://doi.org/10.1007/978-1-4684-8801-2_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8803-6

  • Online ISBN: 978-1-4684-8801-2

  • eBook Packages: Springer Book Archive

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