Summary
Thickening of capillary basement membranes, including those of skeletal muscle, is now widely accepted as the ultrastructural hallmark of diabetic microangiopathy. Although muscle capillary basement membrane thickening has been reported in a limited number of collagen diseases, diabetes mellitus is by far the commonest disease associated with capillary basement membrane thickening. Muscle capillary basement membrane width increases in nondiabetic males essentially throughout life. In nondiabetic females, capillary basement membrane thickening tends to increase less rapidly until after the menopause. In both sexes basement membrane width increases linearly with increasing hydrostatic pressure in muscles below the heart level.
In a series of 138 juvenile-onset diabetics (age 10–24) recently examined, muscle capillary basement membrane width increased significantly with increasing age and with postpubertal duration, but not prepubertal or total duration, of diabetes. These observations indicate that: (1) some, as yet unidentified, puberty-related factor exerts an important permissive effect on muscle capillary basement membrane thickening in diabetic subjects and that (2) muscle capillary basement membrane thickening is, in some way, a consequence of the abnormal metabolic milieu and hormonal imbalances associated with the diabetic state. These interpretations and conclusions are supported by recent studies on monozygotic twins and triplets, discordant for diabetes, which document muscle capillary basement membrane thickening only in those individuals with diabetes.
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References
Ganda, O.M., Soeldner, J.S., Gleason, R.E., Smith, T.M., Kilo, C., and Williamson, J.R. 1977. Monozygotic triplets with discordance for diabetes mellitus and diabetic microangiopathy. Diabetes 26:469–479.
Jackson, R., Guthrie, R., Esterly, J., Bilginturan, N., James, R., Yeast, J., Saathoff, J., and Guthrie, D. 1975. Muscle capillary basement membrane changes in normal and diabetic children. Diabetes 24(Suppl. 2):400 (Abstr.).
Karam, J.H., Rosenthal, M., O’Donnell, J.J., Tsalikian, E., Lorenzi, M., Gerich, J.E., Siperstein, M.D., and Forsham, P.H. 1977. Discordance of diabetic microangiopathy in identical twins. Diabetes 25:24–28.
Kilo, C., Vogler, N., and Williamson, J.R. 1972. Muscle capillary basement membrane changes related to aging and to diabetes mellitus. Diabetes 21:881–905.
Pyke, D.A. and Tattersall, R.B. 1973. Diabetic retinopathy in identical twins. Diabetes 22:613–618.
Sheikholislam, B.M., Irias, J.J., Lin, H-J. Lowrey, G. H. Stephenson, S. R. Peterson, G. E. Devereux, D.F., and Volk, T.L. 1976. Carbohydrate metabolism and capillary basement-membrane thickness in children. I. Cross-sectional studies. Diabetes 25:650–660.
Sheikholislam, B.M., Irias, J.J., Lowrey, G.H., and Lin, H-J. 1976. Carbohydrate metabolism and capillary basement-membrane thickness in children. II. Longitudinal studies. Diabetes 25:661–666.
Siperstein, M.D., Raskin, P., and Burns, H. 1973. Electron microscopic quantification of diabetic microangiopathy. Diabetes 22:514–527.
Williamson, J.R. and Kilo, C. 1976. Basement-membrane thickening and diabetic microangiopathy. Diabetes 25(Suppl. 2):925–927.
Williamson, J.R. and Kilo, C. 1977. Current status of capillary basement-membrane disease in diabetes mellitus. Diabetes 26: 65–75.
Williamson, J.R., Rowold, E., Hoffman, P., and Kilo, C. 1976. Influence of fixation and morphometric technics on capillary basement-membrane thickening prevalence data in diabetes. Diabetes 25:604–613.
Williamson, J.R., Vogler, N.J., and Kilo, C. 1971. Regional variations in the width of the basement membrane of muscle capillaries in man and giraffe. Am. J. Path. 63:359–367.
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© 1979 Plenum Press, New York
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Kilo, C., Williamson, J.R. (1979). Basement Membranes in Muscle Capillaries. In: Klachko, D.M., Anderson, R.R., Burns, T.W., Werner, H.V. (eds) The Endocrine Pancreas and Juvenile Diabetes. Advances in Experimental Medicine and Biology, vol 124. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8508-0_7
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DOI: https://doi.org/10.1007/978-1-4684-8508-0_7
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