Skip to main content
SpringerLink
Log in

Antitumor Agents from Higher Plants

  • Chapter
The Resource Potential in Phytochemistry

Part of the book series: Recent Advances in Phytochemistry ((RAPT,volume 14))

Abstract

Various plant preparations have been recommended for treatment of warts, tumors and cancerous growths throughout recorded history. In a classic survey of the available literature, Hartwell1 identified over 3,000 plants reported to be of use in the treatment of these maladies. Numerous plant extracts have been subjected to detailed testing and fractionation studies in recent years and a wide variety of new active compounds have been isolated. Many of these new materials show promising antitumor activity in animal test systems and in preliminary clinical trials.

The mention of firm names or trade products does not imply that they are endorsed or recommended by the U.S. Department of Agriculture over other firms or similar products not mentioned.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hartwell, J.L. 1967. Plants used against cancer. A survey. Lloydia 30: 379 (with ten additional installments ending with Lloydia 34: 386 ).

    Google Scholar 

  2. Carter, S.K. and R.B. Livingston. 1976.. Plant products in cancer chemotherapy. Cancer Treat. Rep. 60: 1141.

    PubMed  CAS  Google Scholar 

  3. Schepartz, S.A. 1976. History of the National Cancer Institute and the Plant Screening Program. Cancer Treat. Rep. 60: 975.

    PubMed  CAS  Google Scholar 

  4. Perdue, R.E., Jr. 1976. Procurement of plant materials for antitumor screening. Cancer Treat. Rep. 60: 987.

    PubMed  Google Scholar 

  5. Abbott, B.J. 1976. Bioassay of plant extracts for anticancer activity. Cancer Treat. Rep. 60: 1007.

    PubMed  CAS  Google Scholar 

  6. Geran, R.I., N.H. Greenberg, M.M. MacDonald, A.M. Schumacher and B.J. Abbott. 1972. Protocols for screening chemical agents and natural products against animal tumors and other biological systems (Third Edition). Cancer Chemother. Rep. Part 3, 3: 1.

    Google Scholar 

  7. Hartwell, J.L. and B.J. Abbott. 1969. Antineoplastic principles in plants: recent developments in the field. Adv. Pharmacol. Chemother. 7: 117.

    Article  PubMed  CAS  Google Scholar 

  8. Kupchan, S.M. 1975. Advances in the chemistry of tumor-inhibitory natural products. Rec. Adv. Phytochem. 9: 167.

    Article  CAS  Google Scholar 

  9. Hartwell, J.L. 1976. Types of anticancer agents isolated from plants. Cancer Treat. Rep. 60: 1031.

    PubMed  CAS  Google Scholar 

  10. Wall, M.E. and M.C. Wani. 1977. Antineoplastic agents from plants. Annu. Rev. Pharmacol. Toxicol. 17: 117.

    Article  PubMed  CAS  Google Scholar 

  11. Cordell, G.A. 1979. Anticancer agents from plants. Prog. Phytochem. 5: 273.

    Google Scholar 

  12. Pettit, G.R. 1977. Biosynthetic products for cancer therapy. 1: 228 pp.

    Google Scholar 

  13. Tornita, M., H. Furukawa, S.T. Lu and S.M. Kupchan. 1965. The constitution of thalicarpine. Tetrahedron Lett. 4309.

    Google Scholar 

  14. Kupchan, S.M., N. Yokoyama and B.S. Thyagarajan. 1961. Menispermaceae alkaloids. H. The alkaloids of Cyclea peltata Diels. J. Pharm. Sci. 50: 164.

    Article  PubMed  CAS  Google Scholar 

  15. Kupchan, S.M. and A.J. Liepa. 1971. Total synethesis of the tumor-inhibitory alkaloids thalicarpine and hernandaline. Chem. Commun. 599.

    Google Scholar 

  16. Gilmore, C.J., R.F. Bryan and S.M. Kupchan. 1976. Conformation and reactivity of the macrocyclic tumor-inhibitory alkaloid tetrandrine. J. Am. Chem. Soc. 98: 1947.

    Article  PubMed  CAS  Google Scholar 

  17. Sieber, S.M., J.A.R. Mead and R.H. Adamson. 1976. Pharmacology of antitumor agents from higher plants. Cancer Treat. Rep. 60: 1127.

    PubMed  CAS  Google Scholar 

  18. Herman, E.H. and D.P. Chadwick. 1974. Cardiovascular effects of d-tetrandrine. Pharmacology 12: 97.

    Article  PubMed  CAS  Google Scholar 

  19. Panettiere, F. and C.A. Coltman, Jr. 1971. Phase I experience with emetine hydrochloride (NSC 33669) as an antitumor agent. Cancer 27: 835.

    Article  PubMed  CAS  Google Scholar 

  20. Siddiqui, S., D. Firat and S. Olshin. 1973. Phase II study of emetine (NSC 33669) in the treatment of solid tumors. Cancer Chemother. Rep. Part I, 57: 423.

    Google Scholar 

  21. Wall, M.E., M.C. Wani, C.E. Cook, K.N. Palmer, A.T. McPhail and G.A. Sim. 1966. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 88: 3888.

    Article  CAS  Google Scholar 

  22. Wani, M.C. and M.E. Wall. 1969. Plant antitumor agents. II. The structure of two new alkaloids from Camptotheca acuminata. J. Org. Chem. 34: 1364.

    Article  CAS  Google Scholar 

  23. Moertel, C.G., A.J. Schutt, R.J. Reitemeier and R.G. Hahn. 1972. Phase II study of camptothecin (NSC 100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother. Rep. Part I, 56: 95.

    Google Scholar 

  24. Gottlieb, J.A. and J.K. Luce. 1972. Treatment of malignant melanoma with camptothecin (NSC 100880). Cancer Chemother. Rep. Part 1, 56: 103.

    Google Scholar 

  25. Schaeppi, U., R.W. Fleischman and D.A. Cooney. 1974. Toxicity of camptothecin (NSC 100880). Cancer Chemother. Rep. Part 3, 5: 25.

    Google Scholar 

  26. Agarwal, J.S. and R.P. Rastogi. 1973. Chemical constituents of Mappia foetida Miers. Indian J. Chem. 11: 969.

    CAS  Google Scholar 

  27. Tafur, S., J.D. Nelson, D.C. DeLong and G.H. Svoboda. 1976. Antiviral components of Ophiorrhiza mungos. Isolation of camptothecin and 10-methoxycamptothecin. Lloydia 39: 261.

    Google Scholar 

  28. Winterfeldt, E. 1975. Recent Dev. Chem. Nat. Carbon Compd. 6: 9.

    CAS  Google Scholar 

  29. Shamma, M. and V. St. Georgiev. 1974. Camptothecin. J. Pharm. Sci. 63: 163.

    Article  PubMed  CAS  Google Scholar 

  30. Schultz, A.G. 1973. Camptothecin. Chem. Rev. 73: 385.

    Article  PubMed  CAS  Google Scholar 

  31. Svoboda, G.H., G.A. Poore and M.L. Montfort. 1968. Alkaloids of Ochrosia maculata Jacq. (Ochrosia borbonica Gmel.). J. Pharm. Sci. 57: 1720.

    Article  PubMed  CAS  Google Scholar 

  32. Hayat, M., G. Mathé, M.M. Janot, P. Potier, N. Dat-Xuong, A. Cavé, T. Sevenet, C. Kan-Fan, J. Poisson, J. Miet, J. Le Men, F. LeGoffic, A. Gouyette, A. Ahond, L.K. Dalton and T.A. Connors. 1974. Experimental screening of 3 forms and 19 derivatives or analogs of ellipticine: oncostatic effect on L1210 leukemia and immunosuppressive effect of 4 of them. Biomedicine 21: 101.

    PubMed  CAS  Google Scholar 

  33. Herman, E.H., D.P. Chadwick and R.M. Mhatre. 1974. Comparison of the acute hemolytic and cardiovascular actions of ellipticine (NSC 71795) and some ellipticine analogs. Cancer Chemother. Rep. Part 1, 58: 637.

    Google Scholar 

  34. Svoboda, G.H., G.H. Poore, P.J. Simpson and G.B. Boder. 1966. Alkaloids of Acronychia baueri Schott. I. Isolation of the alkaloids and a study of the antitumor and other biological properties of acronycine. J. Pharm. Sci. 55: 758.

    Article  PubMed  CAS  Google Scholar 

  35. Svoboda, G.H. 1966. Alkaloids of Acronychia baueri (Bauerella australiana). II. Extraction of the alkaloids and studies of structure-activity relationships. Lloydia 29: 206.

    CAS  Google Scholar 

  36. Schneider, J., E.L. Evans, E. Grunberg and R.I. Fryer. 1972. Synthesis and biological activity of acronycine analogs. J. Med. Chem. 15: 266.

    Article  PubMed  CAS  Google Scholar 

  37. Beck, J.R., R. Kwok, R.N. Booher, A.C. Brown, L.E. Patterson, P. Pranc, B. Rockey and A. Pohland. 1968. Synthesis of acronycine. J. Am. Chem. Soc. 90: 4706.

    Article  PubMed  CAS  Google Scholar 

  38. Mulchandani, N.B. and S.R. Venkatachalam. 1976. Alkaloids of Pergularia pallida. Phytochemistry 15: 1561.

    Article  CAS  Google Scholar 

  39. Gellert, E., T.R. Govindachari, M.V. Lakshmikantham, I.S. Ragade, R. Rudzats and N. Viswanathan. 1962. The alkaloids of Tylophora crebriflora: structure and synthesis of tylocrebrine, a new phenanthroindolizidine alkaloid. J. Chem. Soc. 1008.

    Google Scholar 

  40. Farnsworth, N.R., A.S. Bingel, H.H.S. Fong, A.A. Saleh, G.M. Christenson and S.M. Sauffer. 1976. Oncogenic and tumor-promoting spermatophytes and pteridophytes and their active principles. Cancer Treat.Rep.60: 1171.

    Google Scholar 

  41. Kupchan, S.M., R.W. Doskotch and P.W. Vanevenhoven. 1964. Tumor inhibitors. III. Monocrotaline, the active principle of Crotalaria spectabilis. J. Pharm. Sci. 53: 343.

    CAS  Google Scholar 

  42. Kugelman, M., W. Liu, M. Axelrod, T.J. McBride and K.V. Rao. 1976. Indicine-N-Oxide: the antitumor principle of Heliotropium indicum. Lloydia 39: 125.

    CAS  Google Scholar 

  43. Kupchan, S.M., Y. Aynehchi, J.M. Cassady, H.K. Schnoes and A.L. Burlingame. 1969. Tumor inhibitors. XL. The isolation and structural elucidation of elephantin and elephantopin, two novel sesquiterpenoid tumor inhibitors from Elephantopus elatus. J. Org. Chem. 34: 3867.

    Article  CAS  Google Scholar 

  44. Kupchan, S.M., R.J. Hemingway, D. Werner and A. Karim. 1969. Tumor Inhibitors. XLVI. Vernolepin, a novel sesquiterpene dilactone tumor inhibitor from Vernonia hymenolepis A. Rich. J. Org. Chem. 34: 3903.

    CAS  Google Scholar 

  45. Kupchan, S.M., M.A. Eakin and A.M. Thomas. 1971. Tumor inhibitors. 69. Structure-cytotoxicity relationships among the sesquiterpene lactones. J. Med. Chem. 14: 1147.

    Article  PubMed  CAS  Google Scholar 

  46. Rodriguez, E., G.H.N. Towers and J.C. Mitchell. 1976. Biological activities of sesquiterpene lactones. Phytochemistry 15: 1573.

    Article  CAS  Google Scholar 

  47. Mitchel, J.C. 1975. Contact allergy from plants. Recent Adv. Phytochem. 9: 119.

    Article  Google Scholar 

  48. Block, J.B., A.A. Serpick, W. Miller and P.H. Wiernik. 1974. Early clinical studies with lapachol (MSC 11905). Cancer Chemother. Rep. Part 2, 4: 27.

    Google Scholar 

  49. Rao, K.V. 1974. Quinone natural products: streptonigrin (NSC 45383) and lapachol (NSC 11905) structure-activity relationships. Cancer Chemother. Rep. Part 2, 4: 11.

    Google Scholar 

  50. Messmer, W.M., M. Tin-Wa, H.H.S. Fong,,,C. Bevelle, N.R. Farnsworth, D.J. Abraham and J. Trojanek. 1972. Fagaronine, a new tumor inhibitor isolated from Fagara zanthoxyloides Lam. (Rutaceae). J. Pharm. Sci. 61: 1858.

    PubMed  CAS  Google Scholar 

  51. Arthur, H.R., W.H. Hui and Y.L. Ng. 1959. An examination of the rutaceae of Hong Kong. Part II. The alkaloids, nitidine and oxynitidine, from Zanthoxylum nitidum. J. Chem. Soc. 1840.

    Google Scholar 

  52. Gillespie, J.P., L.G. Amoros and F.R. Stermitz. 1974. Synthesis of fagaronine. An anticancer benzophenanthridine alkaloid. J. Org. Chem. 39: 3239.

    Article  CAS  Google Scholar 

  53. Ninomiya, I., T. Naito and H. Ishii. 1975. Synthesis of N-demethylfagaronine. Heterocycles 3: 307.

    Article  CAS  Google Scholar 

  54. Stermitz, F.R., K.A. Larson and D.K. Kim. 1973. Some structural relationships among cytotoxic and antitumor benzophenanthridine alkaloid derivatives. J. Med. Chem. 16: 939.

    Article  PubMed  CAS  Google Scholar 

  55. Powell, R.G., D. Weisleder and C.R. Smith, Jr. 1972. Antitumor alkaloids from Cephalotaxus harringtonia: structure and activity. J. Pharm. Sci. 61: 1227.

    Article  PubMed  CAS  Google Scholar 

  56. Corbett, T.H., D.P. Griswold, Jr., B.J. Roberts, J.C. Peckham and F.M. Schable, Jr. 1977. Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas. Cancer 40: 2660.

    Article  PubMed  CAS  Google Scholar 

  57. Weinreb, S.M. and J. Auerbach. 1975. Total synthesis of the Cephalotaxus alkaloids. Cephalotaxine, cephalotaxinone and demethylcephalotaxinone. J. Am. Chem. Soc. 97: 2503.

    Article  CAS  Google Scholar 

  58. Semmelhack, M.F., B.P. Chong, R.D. Stauffer, T.D. Rogerson, A. Chong and L.D. Jones. 1975. Total synthesis of the Cephalotaxus alkaloids. A problem in nucleophilic aromatic substitution. J. Am. Chem. Soc. 97: 2507.

    Article  PubMed  CAS  Google Scholar 

  59. Mikolajczak, K.L., C.R. Smith, Jr., D. Weisleder, T.R. Kelly, J.C. McKenna and P.A. Christenson. 1974. Synthesis of deoxyharringtonine. Tetrahedron Lett. 283.

    Google Scholar 

  60. Anon. 1975. Partial synthesis of harringtonine. ‘Co Hsueh T’ung Pao 20: 437.

    Google Scholar 

  61. Mikolajczak, K.L. and C.R. Smith, Jr. 1978. Synthesis of harringtonine, a Cephalotaxus antitumor alkaloid. J. Org. Chem. 43: 4762.

    Article  CAS  Google Scholar 

  62. Kelly, T.R., R.W. McNutt, M. Montury, N.P. Tosches, K.L. Mikolajczak, C.R. Smith, Jr. and D. Weisleder. 1979. Preparation of harringtonine from cephalotaxine. J. Org. Chem. 44: 63.

    Article  CAS  Google Scholar 

  63. Mikolajczak, K.L. and C.R. Smith, Jr. 1979. Synthetic cephalotaxine esters having antileukemic activity. U.S. Patent 4,152, 333.

    Google Scholar 

  64. Smith, C.R., Jr., K.L. Mikolajczak and R.G. Powell. Harringtonine and related cephalotaxine esters. In Design and Synthesis of Potential Anti-Cancer Agénts Based on Natural Product Models (J.M. Cassady and J.D. Douros, eds). In press.

    Google Scholar 

  65. Anon. 1976. Cephalotaxine esters in the treatment of acute leukemia, a preliminary clinical assessment. Chin. Med. J. (Peking Engl. Ed.) 2: 263.

    Google Scholar 

  66. Anon. 1977. Harringtonine in acute leukemias, clinical analysis of 31 cases. Chin. Med. J. (Peking Engl. Ed.) 3: 319.

    Google Scholar 

  67. Wani, M.C., H.L. Taylor, M.E. Wall, P. Coggon and A.T. McPhail. 1971. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 93: 2325.

    Article  CAS  Google Scholar 

  68. Powell, R.G., R.W. Miller and C.R. Smith, Jr. 1979. Cephalomannine; a new antitumor alkaloid from Cephalotaxus mannii. Chem. Commun. 102.

    Google Scholar 

  69. Polonsky, J. 1973. Quassinoid bitter principles. Prog. Chem. Org. Nat. Prod. 30: 101.

    CAS  Google Scholar 

  70. Kupchan, S.M., R.W. Britton, J.A. Lacadie, M.F. Ziegler and C.W. Sigel. 1975. The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica. J. Org. Chem. 40: 648.

    Article  CAS  Google Scholar 

  71. Ogura, M., G.A. Cordell, A.D. Kinghorn and N.R. Farnsworth. 1977. Potential anticancer agents. VI. Constituents of Ailanthus excelsa (Simaroubaceae). Lloydia 40: 579.

    PubMed  CAS  Google Scholar 

  72. Wani, M.C., H.L. Taylor, J.B. Thompson and M.E. Wall. 1978. Plant antitumor agents. XVI. 6a-Senecioyloxychaparrinone, a new antileukemic quassinoid from Simaba multiflora. Lloydia 41: 578.

    CAS  Google Scholar 

  73. Wall, M.E. and M.C. Wani. 1978. Plant antitumor agents. 17. Structural requirements for antineoplastic activity in quassinoids. J. Med. Chem. 21: 1186.

    Article  PubMed  CAS  Google Scholar 

  74. Evans, F.J. and C.J. Soper. 1978. The tigliane, daphnane and ingenane diterpenes, their chemistry, distribution and biological activities. A review. Lloydia 41: 193.

    CAS  Google Scholar 

  75. Kupchan, S.M., J.G. Sweeny, R.L. Baxter, T. Murae, V.A. Zimmerly and B.R. Sickles. 1975. Gnididin, gniditrin and gnidicin, novel potent antileukemic diterpenoid esters from Gnidia lamprantha. J. Am. Chem. Soc. 97: 672

    Article  CAS  Google Scholar 

  76. Kupchan, S.M., Y. Shizuri, T. Murae, J.G. Sweeny, H.R. Haynes, M.S. Shen, J.C. Barrick, R.F. Bryan, D. van der Helm and K.K. Wu. 1976. Gnidimacrin and gnidimacrin 20-palmitate, novel macrocyclic antileukemic diterpenoid esters from Gnidia subcordata. J. Am. Chem. Soc. 98: 5719.

    Article  CAS  Google Scholar 

  77. Kupchan, S.M. and R.L. Baxter. 1975. Mezerein: anti-leukemic principle isolated from Daphne mezereum L. Science 187: 652.

    CAS  Google Scholar 

  78. Kupchan, S.M., Y. Komoda, W.A. Court, G.J. Thomas, R.M. Smith, A. Karim, C.J. Gilmore, R.C. Haltiwanger and R.F. Bryan. 1972. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J. Am. Chem. Soc. 95: 1354.

    Article  Google Scholar 

  79. Wani, M.C., H.L. Taylor and M.E. Wall. 1973. Plant antitumor agents: colubrinol acetate and colubrinol, antileukaemic ansa macrolides from Colubrina texensis. Chem. Commun. 390.

    Google Scholar 

  80. Kupchan, S.M., Y. Komoda, A.R. Branfman, A.T. Sneden, W.A. Court, G.J. Thomas, N.P.J. Hintz, R.M. Smith, A. Karim, G.A. Howie, A.K. Verma, Y. Nagao, R.G. Dailey, Jr., V.A. Zimmerly and W.C. Sumner, Jr. 1977. The maytansinoids. Isolation, structural elucidation and chemical interrelation of novel ansa macrolides. J. Org. Chem. 42: 2349.

    Article  CAS  Google Scholar 

  81. Kupchan, S.M., A.T. Sneden, A.R. Branfman, G.A. Howie, L.I. Rebhun, W.E. Mclvor, R.W. Wang and T.C. Schnaitman. 1978. Structural requirements for anti-leukemic activity among the naturally occurring and semisynthetic maytansinoids. J. Med. Chem. 21: 31.

    Article  PubMed  CAS  Google Scholar 

  82. Chabner, B.A., A.S. Levine, B.L. Johnson and R.C. Young. 1978. Initial clinical trials of maytansine, an antitumor plant alkaloid. Cancer Treat. Rep. 62: 429.

    PubMed  CAS  Google Scholar 

  83. Kingsbury, J.M. 1964. Poisonous Plants of the United States and Canada, Prentice-Hall, pp. 353–357.

    Google Scholar 

  84. Powell, R.G., C.R. Smith, Jr. and R.V. Madrigal. 1976. Antitumor activity of Sesbania vesicaria, S. punicea and S. drummondii seed extracts. Planta Méd. 30: 1.

    Article  PubMed  CAS  Google Scholar 

  85. Powell, R.G., C.R. Smith, Jr., D. Weisleder, D.A. Muthard and J. Clardy. 1979. Sesbanine, a novel cytotoxic alkaloid from Sesbania drummondii. J. Am. Chem. Soc. 101: 2784.

    Article  CAS  Google Scholar 

  86. Kupchan, S.M., W.A. Court, R.G. Dailey, Jr., C.J. Gilmore and R.F. Bryan. 1972. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J. Am. Chem. Soc. 94: 7194.

    Article  CAS  Google Scholar 

  87. Kupchan, S.M., D.R. Streelman, B.B. Jarvis, R.G. Dailey, Jr. and A.T. Sneden. 1977. Isolation of potent new antileukemic trichothecenes from Baccharis megapotamica. J. Org. Chem. 42: 4221.

    Article  CAS  Google Scholar 

  88. Douros, J. and M. Suffness. 1978. New natural products of interest under development at the National Cancer Institute. Cancer Chemother. Pharmacol. 1: 91.

    Article  PubMed  CAS  Google Scholar 

  89. Jolad, S.D., R.M. Wiedhopf and J.R. Cole. 1975. Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). J. Pharm. Sci. 64: 1889.

    Article  PubMed  CAS  Google Scholar 

  90. Anon. February 19, 1979. Chem. Eng. News., p. 33.

    Google Scholar 

  91. Spencer, G.F., R.D. Plattner and R.G. Powell. 1976. Quantitative gas chromatography and gas chromatography-mass spectrometry of Cephalotaxus alkaloids. J. Chromatogr. 120: 335.

    Article  PubMed  CAS  Google Scholar 

  92. Kupchan, S.M., C.W. Sigel, L.J. Guttman, R.J. Restivo and R.F. Bryan. 1972. Datiscoside, a novel anti-leukemic cucurbitacin glycoside from Datisca glomerata. J. Am. Chem. Soc. 94: 1353.

    Article  CAS  Google Scholar 

  93. Ogura, M., K. Koike, G.A. Cordell and N.R. Farnsworth. 1978. Potential anticancer agents. VIII. Constituents of Baliospermum montanum (Euphorbiaceae). Planta Med. 33: 128.

    Article  PubMed  CAS  Google Scholar 

  94. Loder, J.W. and R.H. Nearn. 1975. 30-Acetoxynorerythrosuamine, a highly cytotoxic alkaloid from Erythrophleum. Tetrahedron Lett. 2497.

    Google Scholar 

  95. Warthen, D., E.L. Gooden and M. Jacobson. 1969. Tumor inhibitors: liriodenine, a cytotoxic alkaloid from Annona glabra. J. Pharm. Sci. 58: 637.

    Article  CAS  Google Scholar 

  96. Galsky, A.G., J.P. Wilsey and R.G. Powell. 1980. Crown-gall tumor disc bioassay: a possible aid in the detection of compounds with antitumor activity. Plant Physiol. 65: 184.

    Article  PubMed  CAS  Google Scholar 

  97. Glogowski, W. and A.G. Galsky. 1978. Agrobacterium tumefaciens site attachment as a necessary prerequisite for crown gall tumor formation on potato discs. Plant Physiol. 61: 1031.

    Article  PubMed  CAS  Google Scholar 

  98. Richardson, C.L. and D.J. Morre. 1978. Chemotherapy of plant tumors: regression of crown gall tumors with D-glucosamine. Bot. Gaz. 139: 196.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Northern Regional Research Center, Agricultural Research, Science and Education Administration, U.S. Department of Agriculture, Peoria, Illinois, 61604, USA

    Richard G. Powell & Cecil R. Smith Jr.

Authors
  1. Richard G. Powell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cecil R. Smith Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Boston University, Boston, Massachusetts, USA

    Tony Swain

  2. Northern Regional Research Center, USDA, Peoria, Illinois, USA

    Robert Kleiman

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Powell, R.G., Smith, C.R. (1980). Antitumor Agents from Higher Plants. In: Swain, T., Kleiman, R. (eds) The Resource Potential in Phytochemistry. Recent Advances in Phytochemistry, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8309-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8309-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8311-6

  • Online ISBN: 978-1-4684-8309-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation