Abstract
Astrocytes and oligodendrocytes develop from neuroectodermal epithelial tissue. Astroglia develop along with the neurons throughout embryogenesis (Fedoroff, 1986; Sturrock, 1986); whereas Oligodendroglia precursor cells, in mouse and rat, are “dormant” during embryogenesis but early postnatally they proliferate and form mature oligodendrocytes (Wood and Bunge, 1984). However, the development of the third type of glia, the microglia, is still a controversial topic. Early evidence, based on morphology, suggested their development from mesodermal tissue outside the central nervous system. It was thought that the precursor cells originated from the pia mater or tela choroidea and then migrated into the CNS (del Rio-Hortega, 1932; Polak et al., 1982). Another suggestion, based on autoradiography using tritiated thymidine, was that microglia originate from neuroepithelium through glioblasts, as do astroglia and Oligodendroglia (Kitamura, 1973; Kitamura et al., 1984).
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© 1991 Plenum Press, New York
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Fedoroff, S., Hao, C. (1991). Origin of Microglia and their Regulation by Astroglia. In: Timiras, P.S., Privat, A., Giacobini, E., Lauder, J., Vernadakis, A. (eds) Plasticity and Regeneration of the Nervous System. Advances in Experimental Medicine and Biology, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8047-4_14
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DOI: https://doi.org/10.1007/978-1-4684-8047-4_14
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