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Autonomous Parvovirus DNA Structure and Replication

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The Parvoviruses

Part of the book series: The Viruses ((VIRS))

Abstract

The genomes of the autonomous parvoviruses are linear, single-strand DNA molecules of about 5100 base pairs (bp) and of minus polarity (complementary to mRNA). There are only minor length differences between parvovirus genomes of various mammalian species including those from mouse, hamster, rat, pig, and man. As will be discussed, genome similarity also extends to secondary structure, replicative intermediates, and, in a more limited sense, to the primary nucleotide sequence. Closely related parvoviruses of rodents additionally exhibit the ability to complement each other for several replicative processes (McMaster et al.,1981; Rhode, 1982), suggesting considerable functional conservation for both cis and trans acting elements. Bearing in mind that species variations do exist, it has been found thus far that all autonomous parvoviruses appear to share a common strategy for replicating their genomes. Therefore, although experimental data for a given structure or replicative process may exist for only one or two parvoviruses, they will be treated as characteristic of the entire virus subgroup.

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Authors and Affiliations

  1. Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA

    William W. Hauswirth

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  1. William W. Hauswirth
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Editors and Affiliations

  1. Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, 32610, Gainesville, Florida, USA

    Kenneth I. Berns

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© 1984 Plenum Press, New York

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Hauswirth, W.W. (1984). Autonomous Parvovirus DNA Structure and Replication. In: Berns, K.I. (eds) The Parvoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8012-2_4

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  • DOI: https://doi.org/10.1007/978-1-4684-8012-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8014-6

  • Online ISBN: 978-1-4684-8012-2

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