Abstract
The different pathogenetic mechanisms responsible for uremic bone disease are still not fully understood. However, as some of the factors involved in the development of renal osteodystrophy have been clarified, it became apparent that abnormalities in phosphate homeostasis play an important role in the control of PTH secretion and in modifying the skeletal response to PTH.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literature
Rehn, E.: Die schnuffelkrankheit des schweines und ihre Beziehung zue Osteitis fibrosa infantilis des Menschen. Beitr. Path. Anat. Allg. Path. 44: 274, 1908.
Slatopolsky, E.; Cagier, S.; Pennel, J.P.; Tagart, D.B.; Canterbury, J.M.; Reiss, E., and Bricker, N.S.: On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J. Clin. Invest. 50: 492, 1971.
Fournier, A.E.; Arnaud, C.D.; Johnson, W.J.; Taylor, W.F., and Goldsmith, R.S.: Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. II. Factors affecting serum immunoreactive parathyroid hormone. J. Clin. Invest. 50: 599, 1971.
Bijvoet, O.L.M.: Relation of plasma phosphate concentration to renal tubular reabsorption of phosphate. Clin. Sci. 37: 23, 1969.
Morgan, B.: Osteomalacia, Renal Osteodystrophy and Osteoporosis. Charles C. Thomas, Springfield, Illinois. 1973.
Swenson, R.S.; Weishinger, J.R.; Ruggi, J.L., and Reaven, G.M.: Evidence that parathyroid hormone is not required for phosphate homeostasis in renal failure. Metabolism 24: 199, 1975.
Loreau, N.; Cosyns, J.P.; Lepreux, C., and Ardaillou, R.: Renal adenylate cyclase, calcitonin receptors and phosphate excretion in rats immunized against tubular basement membranes. In Phosphate Metabolism Proc. 2nd Int. Workshop on Phosphate (Plenum, New York), p. 71, 1977.
Trohler, U.; Bonjour, J.P.; Fleisch, H.: Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroideoparathyroidectomized rats. J. Clin. Invest. 57: 264, 1976.
Friis, Th.; Hahnemann, S.; Weeke, E.: Serum Ca and serum phosphorus in uremia during administration of sodium phytate and aluminum hydroxide. Acta Med. Scand. 183: 497, 1968.
Massry, S.G.; Ritz, E.; Verberckmoes, R.: Role of phosphate in the genesis of secondary hyperparathyroidism of renal failure. Nephron 18: 77, 1977.
Reiss, E.; Canterbury, J.M.; Kanter, A.: Circulating parathyroid hormone concentration in chronic renal insufficiency. Arch. Int. Med. 124: 417, 1969.
Malluche, H.H.; Ritz, E.; Lange, H.P.; Kutschera, J.; Hodgson, M.; Seiffert, U., and Schoeppe, W.: Bone histology in incipient and advanced renal failure. Kidney Int. 9: 355, 1975.
Letteri, J.M.; Cohn, S.H.: Total body neutron activation analysis in the study of mineral homeostasis in chronic renal disease. In Calcium Metabolism in Renal Failure and Nephrolithiasis, John Wiley, New York, 1977.
Massry, S.G.; Coburn, J.W.; Lee, D.B.N.; Jowsey, J., and Kleeman, C.R.: Skeletal resistance to parathyroid hormone in renal failure. Study in 105 human subjects. Ann. Intern. Med. 78: 357, 1973.
Massry, S.G.; Stein, R.; Garty, J.; Arieff, A.I.; Norman, A.W.; Coburn, J.W., and Friedler, R.M.: Skeletal resistance to the calcemic action of PTH in uremia. Role of 1,25(OH)2D3. Kidney Int. 9: 467, 1976.
Llach, F.; Massry, S.G.; Singer, F.R.; Kurokawa, J.; Kaye, J.H., and Coburn, J.W.: Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure. A possible cause for secondary hyperparathyroidism. J. Clin. Endocrin. Metab. 41: 339, 1975.
Frame, B.; Parfitt, A.M.: The syndrome of parathyroid hormone resistance. In Clinical Aspects of Metabolic Bone Disease, Frame, B., et al., eds., Exeerpta Medica, Amsterdam, 1973, p. 454.
Drezner, M.K.; Neelon, F.A.; Haussler, M.; McPherson, H.T., and Lebovitz, H.E.: 1,25 Dihydroxycholecalciferol deficiency: The probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. J. Clin. Endocrin. Metab. 42: 621, 1976.
Bordier, P.J.; Marie, P.J.; Arnaud, C.D.: Evolution of renal osteodystrophy. Kidney Int. Suppl. 2: 102, 1975.
Ivey, J.L.; Morey, E.R.; Liu, C.C.; Rader, J.I.; Baylink, D.J.: Effects of vitamin D and its metabolites on bone. In Vitamin D, Biochemical, Chemical and Clinical Aspects Related to Vitamin D Metabolism, Norman, A.W., et al., eds., de Gruyter, p. 349, 1977.
Krempien, B.; Ritz, E., and Geiger, G.: Behavior of osteocytes in various ages and uremia morphological studies in human cortical bone. In. Proc. First Workshop on Bone Morphometry, Jaworsky, Z.E.G., and Klosevych, S., eds. Univ. of Ottawa Press, p. 288, 1976.
Werner, E.; Malluche, H.H., and Ritz, E.: Intestinale Ca-Absorption im Fruhstadium der Niereninsuffizienz und ihre Beeinflussung durch 5,6-trans-25-OH-CC Verh. Dtsch. Ges. Inn. Med. Vol 83, 1977 (in press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Ritz, E., Malluche, H.H., Krempien, B., Tschope, W., Massry, S.G. (1978). Pathogenesis of Renal Osteodystrophy: Roles of Phosphate and Skeletal Resistance to PTH. In: Massry, S.G., Ritz, E., Rapado, A. (eds) Homeostasis of Phosphate and Other Minerals. Advances in Experimental Medicine and Biology, vol 103. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7758-0_44
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7758-0_44
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7760-3
Online ISBN: 978-1-4684-7758-0
eBook Packages: Springer Book Archive