Abstract
There are many situations where a quick substitution of erythrocytes is warranted. However the need for blood typing generally causes considerable delay in getting the matched erythrocytes. Furthermore, in the case of a catastrophe or war there may be a great demand for blood which cannot be delivered by the blood donors available. In these cases an artificial oxygen-carrying blood substitute which does not require blood typing and which can be stored for a considerable time may save lives. For example, in the case of an accident such a blood substitute is available at once. Another field of application for such solutions lies in chronic peripheral arterial occlusion. It has been shown that in these cases an oxygen-carrying blood substitute is superior to simple isoncotic volume substitution (Moss et al., 1953).
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References
Barnikol, W.K.R. (1982a). Die Feinstruktur der Sauerstoff-HaemoglobinBindungskurve. Funkt. Biol. Med. 1, 46–52.
Barnikol, W.K.R. (1982b). Der Einfluss der Effektoren auf die Feinstruktur der Sauerstoff-Haemoglobin-Bindungskurve. Funkt. Biol. Med. 1, 214–220.
Barnikol, W.K.R. and Burkhard, O. (1983). Feinstruktur der Sauerstoff-Bindung und intermolekulare Wechselwirkung des Haemoglobins im Tierreich: Regenwurm, Frosch, Ente und Forelle. Funkt. Biol. Med. 2, 53–59.
Burkhard, O. and Barnikol, W.K.R. (1983). Die Konzentrations-abhangigkeit molekularspezifischer physikalisch-chemischer und biologischer Eigenschaften des humanen Haemoglobins als Beweis fur intertetramere Wechselwirkungen. Funkt. Biol. Med. 2, 185–193.
Clark, L.C., Jr and Gollan, F. (1966). Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science, 152, 1755–1756.
Gould, S.A., Rosen, A.L., Sehgal, L.R., Sehgal, H.L., Langdale, L.A., Krause, L.M., Rice, C.L., Chamberlin, W.H. and Moss, G.S. (1986). Fluosol-DA as a red cell substitute in acute anemia. N. Engl. J. Med. 314, 1653–1656.
Hirlinger, W.K., Grunert, A., Herrmann, M., Petutschnigk, D. andLanger, K. (1982). Auswirkungen eines teilweisen Blutaustausches mit Fluosol-DA 20% auf den intakten Organismus des Schweines. Anaesthesist, 31, 660–666.
Hunt, C.A., Burnette, R.R., MacGregor, R.D., Strubbe, A.E., Lau, D.T., Taylor, N. and Kawada, H. (1985). Synthesis and evaluation of a prototypal artificial red cell. Science, 230, 1165–1168.
Kothe, N. and Bonhard, K. (1985). Characterization of a modified stroma-free hemoglobin solution as an oxygen-carrying plasma substitute. Surg. Gynecol. Obstet. 161, 563–569.
Lowe, K.C. and Bollands, A.D. (1985). Physiological effects of perfluorocarbon blood substitutes. Med. Lab. Sci. 42, 367–375.
Moss, G.S., Gould, S.A., Sehgal, L.R., Sehgal, H.L. and Rosen, A. (1984). Hemoglobin solution–from tetramer to polymer. In: The Red Cell, Sixth Ann Arbor Conference. Ed. Brewer, G., Alan R. Liss Inc., New York, pp. 191–207.
Nicolau, Y.C. and Gersonde, K. (1977). Irreversible incorporation of allosteric effectors into lipid vesicles to improve unloading by hemoglobin in erythrocytes. Deutsches Patent 2, 740053.
Pabst, R. (1977). Sauerstofftransport mit stromafreien Haemoglobin- losungen und Fluorocarbonen. Med. Klinik, 72, 1555–1562.
Sharma, S.K., Bollands, A.D., Davis, S.S. and Lowe, K.C. (1987). Emulsified perfluorochemicals as physiological oxygen-transport fluids: assessment of a novel formulation. This volume.
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© 1987 Plenum Press, New York
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Barnikol, W.K.R., Burkhard, O. (1987). Highly Polymerized Human Haemoglobin as an Oxygen-Carrying Blood Substitute. In: Silver, I.A., Silver, A. (eds) Oxygen Transport to Tissue IX. Advances in Experimental Medicine and Biology, vol 215. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7433-6_15
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DOI: https://doi.org/10.1007/978-1-4684-7433-6_15
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