Abstract
Although light serves as the adequate stimulus for vision, it can, under certain conditions, have a deleterious effect on the retina. Using rats as experimental animals, Noell et al. (1) were the first to demonstrate that morphological and functional damage to the retina can result from constant light exposures of only a few hours. The manifestations of damage to the retina included the deterioration and death of the photoreceptors with concurrent losses in the amplitude of the electroretinogram (ERG). Moderate light intensity (1,200 to 2,500 lux), several log-units lower than the levels found necessary to produce threshold retinal burns, was used to produce damage. The action spectrum of the damage corresponded to the absorption spectrum of rhodopsin, the rat’s visual pigment, indicating that damage is initiated by the same primary photochemical event as is vision.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Noell, W. K., Walker, V. S., Kang, B. S. and Berman, S. (1966) Invest. Ophthal. 5, 450–473.
Adams, D. O., Beatrice, E. S. and Bedell, R. B. (1972) Science 177, 58–60.
Ts’o, M. O. M. (1973) Invest. Ophthal. 12, 17–34.
Marshall, J., Mellerio, J. and Palmer, D. A. (1972) Expt’l. Eye Res. 14, 164–169.
Lawwill, T. (1973) Invest. Ophthal. 12, 45–51.
Kuwabara, T. and Gorn, R. A. (1968) Archs. Ophthal. 79, 69–78.
Reuter, J. H. and Hobbelen, J. F. (1977) Physiol. Behav. 18, 939–944.
Gorn, R. A. and Kuwabara, T. (1967) Arch. Ophthal. 77, 115–118.
Kuwabara, T. (1970) Amer. J. Ophthal. 70, 187–198.
O’Steen, W. K., Shear, C. R. and Anderson, K. V. (1972) J. Anat. 134, 5–22.
Hannson, H. A. (1970) Virchows Archives B, 6, 247–262.
O’Steen, W. K. and Anderson, K. V. (1972) Expt’1. Neurology 34, 446–454.
Bennett, M. H., Dyer, R. F. and Dunn, J. D. (1973) Expt’l Neurology 38, 80–89.
Grignolo, A., Orzalesi, N., Castellazzo, R. and Vittone, P. (1969) Opthalmologica 157, 43–59.
Friedman, E. and Kuwabara, T. (1968) Archs. Opthal. 80, 265–280.
Rapp, L. M. and Williams, T. P. (1977) Nature 267, 835–836.
O’Steen, W. K. and Kraeer, S. L. (1977) Invest. Ophthal. 16, 940–946.
LaVail, M. M. (1976) Invest. Ophthal. 15, 64–70.
Cone, R. A. and Cobb, W. H., III. (1969) Nature 221, 820–822.
O’Steen, W. K. and Lytle, R. B. (1971) Amer. J. Anat. 130, 227–234.
O’Steen, W. K., Anderson, K. V. and Shear, C. R. (1974) Invest. Ophthal. 13, 334–341.
Olafson, R. P. and O’Steen, W. K. (1976) Invest. Ophthal. 15, 869–874.
Reuter, T. E., White, R. H. and Wald, G. (1971) J. Gen. Physiol. 58, 351–371.
Besharse, J. C., Hollyfield, J. G. and Rayborn, M. E. (1977) J. Cell Biol. 75, 507–527.
Battelle, B. and LaVail, M. M. (1978) Exp. Eye Res. 26, 487–497.
Organisciak, D. T. and Noell, W. K. (1977) Invest. Ophthal. 16, 188–190.
Noell, W. K. and Albrecht, R. (1971) Science 172, 76–80.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Press, New York
About this chapter
Cite this chapter
Rapp, L.M., Williams, T.P. (1980). A Parametric Study of Retinal Light Damage in Albino and Pigmented Rats. In: Williams, T.P., Baker, B.N. (eds) The Effects of Constant Light on Visual Processes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7257-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7257-8_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7259-2
Online ISBN: 978-1-4684-7257-8
eBook Packages: Springer Book Archive