Abstract
Irrespective of the degree of complexity, the point of departure for an analysis of functional activity in the nervous system lies with the neuronal plasmalemma. This is a fundamental axiom of neurophysiology. It is based upon the fact that function is a bioelectrical phenomenon which derives its origin from intrinsic properties and activities of the excitable membrane. It follows, therefore, that any attempt to link a biochemical parameter to function must ultimately show an effect on membrane properties and/or biological activity. It is self-evident that such relationships can be established only after greater understanding has been achieved of the molecular biology of the excitable membrane. The classical paucimolecular model of membrane structure and organization, while having served its purpose well as a formative construct, must now be regarded as being anachronistic and too simplistic, especially in light of recent chemical and spectroscopic analyses of various membrane systems. However, in addition to the need to formulate new concepts regarding molecular organization and dynamics, another area concerning the membrane that must receive attention is the origin of membrane macromolecules (i.e., specification and synthesis of membrane proteins).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Austin, L., and Morgan, I. G. (1967). J. Neurochem., 14: 377.
Autilio, L. A., Appel, S. H., Pettis, P., and Gambetti, P. L. (1968). Biochemistry, 7: 2615.
Beattie, D. S., Basford, R. E., and Koritz, S. B. (1967). J. Biol. Chem., 242: 4584.
Blasie, J. K., Dewey, M. M., Blaurock, A. E., and Worthington, C. R. (1965). J. Mol. Biol., 14: 143.
Burdman, J. A., and Journey, L. J. (1969). J. Neurochem., 16: 493.
Clouet, D., and Waelsch, H. (1961). J. Neurochem., 8: 201.
de Lorenzo, A. J. D., Dettbarn, W. D., and Brzin, M. (1969). J. Ultrastruct. Res., 28: 27.
Droz, B. (1967). J. Microscopie, 6: 201.
Eccles, J. C. (1964). The Physiology of Synapses. New York: Academic Press.
Eccles, J. C. (1967). J. Neurochem., 14: 239.
Eccles, J. C. (1967). J. Neurochem., 14: 239.
Edström, J.-E., and Hökfelt, T. (1969). J. Neurochem., 16: 53.
Edström, J.-E., and Sjöstrand, J. (1969). J. Neurochem., 16: 67.
Edström, J.-E., and Sjöstrand, J. (1964). In: Methods of Cell Phys-iology, Prescott, D., ed. New York: Academic Press.
Eichner, D., and Edström, J.-E. (1962). Biochim. Biophys. Acta, 61: 178.
Fischer, S., and Litvak, S. (1967). J. Cell Physiol., 70: 69.
Grampp, W., and Edström, J.-E. (1963). J. Neurochem., 10: 725.
Guiditta, A., Dettbarn, W. D., and Brzin, M. (1968). Proc. Nat. Acad. Sci., U.S.A., 59: 1284.
Hodgkin, A. L. (1958). Proc. Roy. Soc., Ser. B., 148: 1.
Huxley, A. F., and Katz, B. (1952). J. Physiol., 116: 424.
Howarth, J., Keynes, R., and Ritchie, J. (1968). J. Physiol., 194: 745.
Koenig, E. (1965a). J. Neurochem., 12: 343.
Koenig, E. (1965b). J. Neurochem., 12: 357.
Koenig, E. (1967a). J. Neurochem., 14: 429.
Koenig, E. (1967b). J. Neurochem., 14: 437.
Koenig, E. (1967c). J. Cell Biol., 34: 265.
Koenig, E. (1968a). J. Cell Biol., 38: 562.
Koenig, E. (1968b). In: Macromolecules and the Function of the Neuron, Lodin, Z., and Rose, S. P. R., eds. Amsterdam Excerpta Medica.
Koenig, E. (1969). In: Handbook of Neurochemistry, Vol. 2, Lajtha, A., ed. New York: Plenum Press
Koenig, E. (1970). In: Biochemistry of Simple Neuronal Models, Costa, E., and Giacobini, E., eds. New York: Raven Press.
Koenig, E. (1970a). In: Protein Metabolism of the Nervous System, Lajtha, A., ed., New York: Plenum Press.
Koenig, E. and Koelle, G. B. (1961). J. Neurochem., 8: 169.
Kroon, M. (1965). Biochim. Biophys. Acta, 108: 275.
Lamb, A. J., Clark-Walker, G. D., and Linnane, A. W. (1968). Biochim. Biophys. Acta, 161: 415.
Lasek, R. J. (1970). J. Neurochem., 17: 103.
Morgan, I. R., and Austin, L. (1968). J. Neurochem., 15: 41.
Narahashi, T., Anderson, N. C., and Moore, J. W. (1967). J. Gen. Physiol., 50: 1413.
Nass, M. M. K. (1969). Science, 165: 25.
Nilsson, S. E. G. (1964). J. Ultrastruct. Res., 11: 581.
Palay, S. L., and Palade, G. E. (1955). J. Biophys. Biochem. Cytol., 1: 69.
Pearse, A. G. E. (1961). In: The Structure of the Eye, Smelser, K., ed. New York: Academic Press.
Purpura, D. P. (1967). In: The Neurosciences, Quarton, G. C., Melnechuk, T., and Schmitt, F. O., eds. New York: Rockefeller Univ. Press.
Reed, L. J. (1967). In: The Neurosciences, Quarton, G. C., Melnechuk, T., and Schmitt, F. O., eds. New York: Rockefeller Univ. Press.
Reich, E. (1964). Science, 143: 684.
Reid, B. R., and Cole, R. D. (1964). Proc. Nat. Acad. Sci. U.S.A., 51: 1044.
Schaffer, K. (1893). Neurol. Centralbl. ( Leipzig ), 12: 849.
Siegel, M. R., and Sisler, H. D. (1965). Biochim. Biophys. Acta, 103: 558.
Singer, M., and Bryant, S. V. (1969). Nature (London), 221: 1148.
Singer, M., and Green, M. R. (1968). J. Morph., 124: 321.
Tasaki, I., Carnay, L., Sandlin, R., and VVatnabe, A. (1969). Science, 163: 683.
Tompkins, G. M., Gelehrter, T. D., Martin, D. G. D., Samuels, H. H., and Thompson, E. B. (1969). Science, 1474.
Wolkin, J. J. (1966). Vision. Springfield, Ill: Thomas.
Young, R. W. (1967). J. Cell. Biol. 33: 61.
Young, R. W., and Droz, B. (1968). J. Cell Biol., 39: 169.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1972 Meredith Corporation
About this chapter
Cite this chapter
Koenig, E. (1972). A Molecular Basis for Regional Differentiation of the Excitable Membrane. In: Gaito, J. (eds) Macromolecules and Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6042-1_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6042-1_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6044-5
Online ISBN: 978-1-4684-6042-1
eBook Packages: Springer Book Archive