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LTB4 and PAF in the Cytokine Network

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Cell-Cell Interactions in the Release of Inflammatory Mediators

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 314))

Abstract

In most instances when the host is asked to mount a specific immune response, the initial event or the subsequent response, or both, are associated with non-specific inflammation. In recent years, with the identification of numerous molecular and cellular components of the inflammatory response, investigators have initiated studies of potential interactions between the latter and the protagonists of more specific immunological reactions. In particular, soluble mediators of inflammation, produced by phagocytes, endothelial cells or nerves have been studied in regard to their possible modulation of lymphocyte and monocyte-macrophage functions. In the present chapter, we will focus on a group of lipid molecules, the leukotrienes (LTs) and platelet-activating factor (PAF), and their potential role in modulation of the immune response at the cytokine level.

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Authors and Affiliations

  1. Immunology Division, Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada, J1H 5N4

    Marek Rola-Pleszczynski

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  1. Marek Rola-Pleszczynski
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  1. New York Medical College, Valhalla, New York, USA

    Patrick Y.-K. Wong

  2. Harvard Medical School, Boston, Massachusetts, USA

    Charles N. Serhan

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Rola-Pleszczynski, M. (1991). LTB4 and PAF in the Cytokine Network. In: Wong, P.YK., Serhan, C.N. (eds) Cell-Cell Interactions in the Release of Inflammatory Mediators. Advances in Experimental Medicine and Biology, vol 314. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6024-7_13

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  • DOI: https://doi.org/10.1007/978-1-4684-6024-7_13

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