Abstract
The neutrophil attracting/activating peptide (NAP-1), also called IL-8, was discovered as a result of its chemotactic activity for human neutrophils in vitro (1,2,3). In addition, NAP-1, similarly to other known chemotaxins, has potent neutrophil secretory activity in vitro (1,2,3). NAP-1 is the first described cytokine which attracts neutrophils and the first known chemoattractant acting on neutrophils, but not monocytes. Therefore, on the basis of its behaviour in vitro, one can suggest that NAP-1 and also the recently discovered NAP-2 (4) and NAP-3 (5) (all three belong to the C-X-C cytokine family, exhibit considerable structural homology and have analogous activities in vitro) could be responsible for the induction of the inflammatory cellular infiltrates dominated by neutrophils.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Baggiolini, M., A. Walz, and S.L. Kunkel. 1989. Neutrophil activating peptide- 1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest. 84: 1045–1049.
Matsushima, K. and J.J. Oppenheim. 1989. Interleukin 8 and MCAF: Novel inflammatory cytokines inducible by IL-1 and TNF. Cytokine. 1: 2–13.
Leonard, E.J. and T. Yoshimura. 1990. Neutrophil attractant/activation protein-1 [NAP-1 (IL-8)]. Am. J. Resp. Cell. Mol. Biol. 2: 479–486.
Walz, A., B. Dewald, V. Tscharner and M. Baggiolini. 1989. Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III, and platelet factor 4 on human neutrophils. J. Exp. Med. 170: 1745–1750.
Schröder, J-M., N.L.M. Persoon, and E. Christophers. 1990. Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophilactivating protein. J. Exp. Med. 171: 1091–1100.
Colditz, I.G. 1985. Margination and emigration of leucocytes. Surv. Synth. Path. Res. 4: 44–68.
Foster A., D.M. Aked, J-M. Schröder, and E. Christophers. 1989. Acute inflammatory effects of a monocyte-derived Neutrophil-activating peptide in rabbit skin. Immunology. 67: 181–183.
Carveth, H.J., J.F. Bohnsack, T.M. Mclntyre, M. Baggiolini, S.M. Prescott, and G.A. Zimmerman. 1989. Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. Biochem. Biophys. Res. Commun. 162: 387–393.
Detmers, P.A., S.K. Lo, E. Olsen-Egbert, A. Walz, M. Baggiolini, and Z.A. Cohn. 1990. Neutrophil-activating protein 1-interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J. Exp. Med. 171: 1155–1162.
Dustin, M.L., R. Rothlein, A.K. Bhan, C.A. Dinarello, and T.A. Springer. 1986. Induction by IL-1 and interferon-gamma: tissue distribution, biochemistry, and function of natural adherence molecule (ICAM-1). J. Immunol. 137: 245–254.
Bevilacqua, M.P., S. Stengelin, M.A. Gimbrone, Jr. and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 243: 1160–1165.
Lindley I., H. Aschauer, J-M. Seifert, C. Lam, W. Brunowsky, E. Kownatzky, M. Thelen, P. Peveri, B. Dewald, V. von Tscharner, A. Walz, M. Baggiolini. 1988. Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: Biological equivalence between natural and recombinant neutrophil activating factor. Proc. Natl. Acad. Sci. USA. 85: 9199–9203.
Styrt, B. 1989. Species variation in neutrophil biochemistry and function. J. Leukocyte Biol. 46: 63–74.
Rot, A. 1990. The role of leukocyte Chemotaxis in inflammation. In: Biochemistry of Inflammation, eds. Evans, S. and J. Whicher, MTP Press, Lancaster. (In press).
Rot, A., C. Lam, and I.J.D. Lindley. 1989. Recombinant human NAP-1 shows differing chemotactic and stimulatory activity on cells from different species. Cytokine. 1: 147.
Demling, R.H. 1990. Current concepts on the adult respiratory distress syndrome. Circulatory Shock. 30: 297–309.
Tracey, K.J., B. Beutler, S.F. Lowry, J. Merryweather, S. Wolpe, I.W. Milsark, R.J. Hariri, T.J. Fahey III, A. Zentella, J.D. Albert, G.T. Shires, and A. Cerami. 1986. Shock and tissue injury induced by recombinant human cachectin. Science. 234: 470–474.
Goldblum, S.E., K. Yoneda, D.A. Cohen, and C.J. McClain. 1988. Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-1. Infection and Immunity. 56: 2255–2262.
Till, G.O. and P.A. Ward. 1986. Systemic complement activation and acute lung injury. Fed. Proc. 45: 13–18.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Rot, A. (1991). Some Aspects of NAP-1 Pathophysiology: Lung Damage Caused by a Blood-Borne Cytokine. In: Westwick, J., Lindley, I.J.D., Kunkel, S.L. (eds) Chemotactic Cytokines. Advances in Experimental Medicine and Biology, vol 305. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6009-4_15
Download citation
DOI: https://doi.org/10.1007/978-1-4684-6009-4_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-6011-7
Online ISBN: 978-1-4684-6009-4
eBook Packages: Springer Book Archive