Abstract
Profound insulin-induced hypoglycemia is associated with neurodegenera-tion which resembles lesions produced by administration of exogenous excito-toxins (Auer, 1986). Neuronal lesions in hypoglycemia begin within minutes of the hypoglycemie insult and are attenuated by local application of N-methyl-D-aspartate (NMDA) receptor antagonists (Wieloch 1985; Simon et al., 1986).
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References
Agardh, C.-D., Carlsson, A., Lindqvist, M., and Siesjö, B.K., 1979, The effect of pronounced hypoglycemia on monoamine metabolism in rat brain, Diabetes, 28: 804–809.
Auer, R.N., 1986, Progress review: hypoglycémie brain damage, Stroke, 17: 699–708.
During, M.J., Heyes, M.P., Freese, A., Markey, S.P., Martin, J.B., and Roth, R.H., 1989, Quinolinic acid concentrations in striatal extracellular fluid reach potentially neurotoxic levels following systemic L-tryptophan loading, Brain Res., 476: 384–387.
Fernstrom, J.D., 1983, Role of precursor availability in control of monoamine biosynthesis in brain, Physiol. Rev., 63: 484–564.
Heyes, M.P., Hutto, B., and Markey, S.P., 1988, 4-chloro-3-hydroxyanthranil-ic acid inhibits 3-hydroxyanthranilic acid oxidase in brain, Neurochem. Int., 13: 405–409.
Heyes, M.P., and Markey, S.P., 1988a, Quantification of quinolinic acid in rat brain, whole blood and plasma by gas chromatography and negative chemical ionization mass spectrometry: Effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations, Anal. Biochem., 174: 349–359.
Heyes, M.P., and Markey, S.P., 1988b, [18O]-quinolinic acid: its esterification without back exchange for use as internal standard in the quantification of brain and CSF quinolinic acid, Biomed. Environ. Mass Spectrom., 15: 291–293.
Lapin, I.P., 1982, Convulsant action of intracerebroventricularly administered 1-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationships, Neuropharmacology, 21: 1227–1233.
Schwarcz, R., Whetsell, W.O., and Mangano, R.M., 1983, Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain, Science, 219: 316–318.
Simon, R.P., Schmidley, J.W., Meldrum, B.S., Swan, J.H., and Chapman, A.G., 1986, Excitotoxic mechanisms in hypoglycemie hippocampal injury, Neuro-pathol. Appl. Neurobiol., 12: 567–576.
Snoke, R.E., Johnston, J.B., and Lardy, H.A., 1971, Response of phospho-pyruvate carboxylase to tryptophan metabolites and metal ions, Eur. J. Biochem., 24: 342–346, 1971.
Wieloch, T., 1985, Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist, Science, 230: 681–683.
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© 1991 Plenum Press, New York
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Heyes, M.P., Papagapiou, M., Leonard, C., Markey, S.P., Auer, R.N. (1991). Effects of Profound Insulin-Induced Hypoglycemia on Quinolinic Acid in Hippocampus and Plasma. In: Schwarcz, R., Young, S.N., Brown, R.R. (eds) Kynurenine and Serotonin Pathways. Advances in Experimental Medicine and Biology, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5952-4_92
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DOI: https://doi.org/10.1007/978-1-4684-5952-4_92
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