Skip to main content
SpringerLink
Log in

Insulin-Like Growth Factor Binding Proteins in the Nervous System

  • Chapter
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 293))

Abstract

Insulin-like growth factor binding proteins (IGFBPs) are a group of discrete but structurally related polypeptides,1–3 which bind and modulate the biological activity of insulin-like growth factors (IGFs) I and II.4–9 Since available evidence suggests that IGF-I and -II participate in growth, metabolism, differentiation, and injury repair,10–24 to name just a few biologic processes in which IGFs are implicated, IGFBPs may have important regulatory actions in these and other diverse biological processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. M.T. Brewer, G.L. Stetler, C.H. Squires, R.C. Thompson, W.H. Busby, and D.R. Clemmons, Cloning, characterization, and expression of a human insulin-like growth factor binding protein, Biochem Biophys Res Commun 152:1289 (1988).

    Article  PubMed  CAS  Google Scholar 

  2. J.B. Margot, C. Binhert, J.-L. Mary, J. Landwehr, G. Heinreich, and J. Schwander, A low molecular weight insulin-like growth factor binding protein from the rat: cDNA cloning and tissue distribution of its messenger RNA, Mol Endocrinol 3:1053 (1989).

    Article  PubMed  CAS  Google Scholar 

  3. S. Shimisaki, A. Koba, M. Mercado, M. Shimonaka, and N. Ling, Complementary DNA structure of the high molecular weight rat insulinlike growth factor binding protein (IGF-BP3) and tissue distribution of its mRNA, Biochem Biophys Res Commun 165:907 (1989).

    Article  Google Scholar 

  4. V.K.M. Han, J.M. Lauder, and A.J. D’Ercole, Rat astroglial somatomedin/insulin-like growth factor binding proteins: characterization and evidence of biologic function, J Neurosci8:3135 (1988).

    PubMed  CAS  Google Scholar 

  5. A.G. Frauman, S. Tsuzaki, and A.C. Moses, The binding characteristics and biological effects in FRTL5 cells of placental protein-12, an insulin-like growth factor-binding protein purified from human amniotic fluid, Endocrinology 124:2289 (1989).

    Article  PubMed  CAS  Google Scholar 

  6. W.M.Burch, J. Correa, J.E. Shively, and D.R. Powell, The 25-kiloDalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro, J Clin Endocrinol Metab 70:173 (1990).

    Article  PubMed  CAS  Google Scholar 

  7. R.S. Bar, B.A. Booth, M. Boes, and B.L. Dake, Insulin-like growth factor-binding proteins from vascular endothelial cells: purification, characterization, and intrinsic biological activities, Endocrinology 125:1910 (1989).

    Article  PubMed  CAS  Google Scholar 

  8. W.H. Busby, P. Hossenlopp, M. Binoux, and D.R. Clemmons, Purified preparations of the amniotic fluid-derived insulin-like growth factor-binding protein contain multimeric forms that are biologically active, Endocrinology 125:773 (1989).

    Article  PubMed  CAS  Google Scholar 

  9. W.F. Blum, E.W. Jenne, F. Reppin, K. Kietzmann, M.B. Ranke, and J.R. Bierich Insulin-like growth factor I (IGF-I)-binding protein complex is a better mitogen than free IGF-I, Endocrinology 125:766 (1989).

    Article  PubMed  CAS  Google Scholar 

  10. E. Recio-Pinto, F.F. Lang, and D.N. Ishii, Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells, Proc Natl Acad Sci USA 81:2562 (1984).

    Article  PubMed  CAS  Google Scholar 

  11. E. Recio-Pinto, M.M. Rechler, and D.N. Ishii, Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons, J Neurosci 6:1211 (1986).

    PubMed  CAS  Google Scholar 

  12. Y. Aizenman and J. deVellis, Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin, insulin-like growth factor I and thyroid hormone on neuronal survival, growth and differentiation, Brain Res 406:32 (1987).

    Article  PubMed  CAS  Google Scholar 

  13. J. Shemer, M.K. Raizada, B.A. Masters, A. Ota, and D. Leroith, Insulinlike growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture, J Biol Chem 262:7693 (1987).

    PubMed  CAS  Google Scholar 

  14. S.K. Burgess, S. Jacobs, P. Cuatrecasas, and N. Sahyoun, Characterization of a neuronal subtype of insulin-like growth factor I receptor, J Biol Chem 262:1618 (1987).

    PubMed  CAS  Google Scholar 

  15. R. Ballotti, F.G. Nielsen, N. Pringle, A. Kowalski, W.D. Richardson, E. Van Obberghen, and S. Gammeltoft, Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase, EMBO J 6:3633 (1987).

    PubMed  CAS  Google Scholar 

  16. E. DiCicco-Bloom and I.B. Black, Insulin-like growth factors regulate the mitotic cycle of cultured rat sympathetic neuroblasts, Proc Natl Acad Sci USA 85:4066 (1988).

    Article  PubMed  CAS  Google Scholar 

  17. F.A. McMorris and M. Dubois-Dalcq, Insulin-like growth factor I promotes Cell Proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro, J Neurosci Res 21: 199 (1988).

    Article  PubMed  CAS  Google Scholar 

  18. D.N. Ishii, Relationship of insulin-like growth factor II gene expression in muscle synaptogenesis, Proc Natl Acad Sci USA 86:2898 (1989).

    Article  PubMed  CAS  Google Scholar 

  19. H.A. Hansson, B. Rozell, and A. Skottner, Rapid axoplasmic transport of insulin-like growth factor I in the sciatic nerve of adult rats, Cell Tiss Res 247:241 (1987).

    Article  CAS  Google Scholar 

  20. J. Sjoberg and M. Kanje, Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve, Brain Res 485:102 (1989).

    Article  PubMed  CAS  Google Scholar 

  21. D.P. Figlewicz, S.C. Woods, D.G. Baskin, D.M. Dorsa, B.J. Wilcox, L.J. Stein, and D. Porte Jr., Insulin in the central nervous system: a regulator of appetite and body weight, in: “Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System,” M. K. Raizada, M.I. Phillips, D. Leroith, eds., Plenum Press, New York (1987).

    Google Scholar 

  22. G.S. Tannenbaum, H.J. Guyda, and B.I. Posner, Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain, Science 220:77 (1983).

    Article  PubMed  CAS  Google Scholar 

  23. T.J. Lauterio TJ, L. Marson, W.H. Daughaday, and C.A. Baile, Evidence for the role of insulin-like growth factor II (IGF-II) in the control of food intake, Physiol Behav 40:755 (1987).

    Article  PubMed  CAS  Google Scholar 

  24. R.G. Rosenfeld and A.R. Hoffman, Insulin-like growth factors and their receptors in the pituitary and hypothalamus, in: “Insulin, Insulinlike Growth Factors, and Their Receptors in the Central Nervous System,” M.K. Raizada, M.I. Phillips, and D. Leroith, eds., Plenum Press, New York (1987).

    Google Scholar 

  25. Y.W.-H. Yang, A.L. Brown, C.C. Orlowski, D.E. Graham, L.Y.-H. Tseng, J.A. Romanus, and M.M. Rechler, Identification of rat cell lines that preferentially express insulin-like growth factor binding proteins rIGFBP-1,2, or 3, Mol Endocrinol 4:29 (1990).

    Article  PubMed  CAS  Google Scholar 

  26. S.M. Donovan, Y. Oh, H. Pham, and R.G. Rosenfeld, Ontogeny of serum insulin-like growth factor binding proteins in the rat, Endocrinology125:2621 (1989).

    Article  PubMed  CAS  Google Scholar 

  27. Baxter R.C. Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex, J Clin Endocrinol Metab 67:265 (1988).

    Article  PubMed  CAS  Google Scholar 

  28. J.A. Romanus, L.Y.-H. Tseng, Y.W.-H. Yang, and M.M. Rechler, The 34 kiloDalton insulin-like growth factor binding protein in human cerebrospinal fluid and the A673 rhabdomyosarcoma cell line are human homologues of the rat BRL-3A binding protein, Biochem Biophys Res Commun 163:875 (1989).

    Article  PubMed  CAS  Google Scholar 

  29. P. Hossenlopp, D. Seurin, B. Segovia-Quinson, and M. Binoux, Identification of an insulin-like growth factor-binding protein in human cerebrospinal fluid with a selective affinity for IGF-II, FEBS Lett 208:439 (1986).

    Article  PubMed  CAS  Google Scholar 

  30. M. Roghani, P. Hossenlopp, P. Lepage, A. Ballard, and M. Binoux, Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II, FEBS Lett 255:253 (1989).

    Article  PubMed  CAS  Google Scholar 

  31. R.G. Rosenfeld, H. Pham, C.A. Conover, R.L. Hintz, and R.C. Baxter, Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal fluid and amniotic fluid, J Clin Endocrinol Metab 68:638 (1989).

    Article  PubMed  CAS  Google Scholar 

  32. R.G. Rosenfeld, H. Pham, Y. Oh, G. Lamson, and L.C. Guidice, Identification of insulin-like growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight IGF-BP in human seminal plasma, J Clin Endocrinol Metab 70:551 (1989).

    Article  Google Scholar 

  33. M. Binoux and P. Hossenlopp, Insulin-like growth factor (IGF) and IGF-binding proteins: comparison of human serum and lymph, J Clin Endocrinol Metab 67:509 (1988).

    Article  PubMed  CAS  Google Scholar 

  34. A.N. Corps, K.D. Brown, L.H. Rees, J. Carr, and C.G. Prosser, The insulin-like growth factor I content in human milk increases between early and full gestation, J Clin Endocrinol Metab 67:25 (1988).

    Article  PubMed  CAS  Google Scholar 

  35. M. Seppala, T. Wahlstrom, A.I. Koskimies, A. Tenhunen, E.-M. Rutanen, R. Koistinen, I. Huhtaniemi, H. Bohn, and U.-H. Stenman, Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12, J Clin Endocrinol Metab 58:505 (1984).

    Article  PubMed  CAS  Google Scholar 

  36. S.L.S. Drop, On the nomenclature of the insulin-like growth factor binding proteins, Mol Cell Endocrinol 67:243 (1989).

    Article  PubMed  CAS  Google Scholar 

  37. C.A. Conover, Regulation of insulin-like growth factor (IGF)-binding protein synthesis by insulin and IGF-I in cultured bovine fibroblasts, Endocrinology 126:3139 (1990).

    Article  PubMed  CAS  Google Scholar 

  38. M.S. Lewitt and R.C. Baxter, Inhibitors of glucose uptake stimulate the production of insulin-like growth factor-binding protein (IGFBP-1) by human fetal liver, Endocrinology 126:1527 (1990).

    Article  PubMed  CAS  Google Scholar 

  39. Reviewed in: Molecular and cellular biology of insulin-like growth factors and their receptors, D. Leroith and M.K. Raizada, eds., Plenum Press, New York (1990).

    Google Scholar 

  40. I, Ocrant, C.T. Fay, and J.T. Parmelee, Characterization of insulin-like growth factor binding proteins produced in the rat central nervous system, Endocrinology 127:1260 (1990).

    Article  PubMed  CAS  Google Scholar 

  41. I. Ocrant, C.T. Fay, and J.T. Parmelee, Expression of insulin and insulin-like growth factors and binding proteins by retinal pigment epithelium, Exp Eye Res, in press.

    Google Scholar 

  42. L.Y.-H. Tseng, A.L. Brown, Y.W.-H. Yang, J. A. Romanus, C.C. Orlowski, T. Taylor, and M.M. Rechler, The fetal rat binding protein for insulin-like growth factors is expressed in the choroid plexus and cerebrospinal fluid of adult rats, Mol Endocrinol 3:1559 (1989).

    Article  PubMed  CAS  Google Scholar 

  43. I. Ocrant, H. Pham, Y. Oh, and R.G. Rosenfeld, Characterization of insulin-like growth factor binding proteins of cultured rat astroglial and neuronal cells, Biochem Biophys Res Commun 159:1316 (1989).

    Article  PubMed  CAS  Google Scholar 

  44. S. Shimasaki, A. Kobu, M. Mercado, M. Shimonaka, and N. Ling, Complementary DNA structure of the high molecular weight rat insulinlike growth factor binding protein (IGF-BP3) and tissue distribution of its mRNA, Biochem Biophys Res Commun 165:907 (1989).

    Article  PubMed  CAS  Google Scholar 

  45. D.J. Hill, D.R. Clemmons, S. Wilson, V.K.M. Han, A.J. Strain, and R.D.G. Milner, Immunological distribution of one form of insulin-like growth factor (IGF)-binding protein and IGF peptides in human fetal tissues, J Mol Endocrinol 2:31 (1989).

    Article  PubMed  CAS  Google Scholar 

  46. L.J. Murphy, C. Seneviratne, G. Ballejo, F. Croze, and T.G. Kennedy, Identification and characterization of a rat decidual insulin-like growth factor-binding protein complementary DNA, Mol Endocrinol 4:329 (1990).

    Article  PubMed  Google Scholar 

  47. G.T. Ooi, C.C. Orlowski, A.L. Brown, R.E. Becker, T.G. Unterman, and M.M. Rechler, Differential tissue distribution and hormone regulation of messenger RNAs encoding rat insulin-like growth factor-binding proteins-1 and -2, Mol Endocrinol 4:321.

    Google Scholar 

  48. G. Lamson, H. Pham, Y. Oh, I. Ocrant, J Schwander, and R.G. Rosenfeld, Expression of the BRL-3A insulin-like growth factor binding protein (rBP-30) in the rat central nervous system, Endocrinology 123:1100 (1989).

    Article  Google Scholar 

  49. R.G. Rosenfeld, H. Pham, Y. Oh, and I. Ocrant, Characterization of insulin-like growth factor-binding proteins in cultured rat pituitary cells, Endocrinology 124:2867 (1989).

    Article  PubMed  CAS  Google Scholar 

  50. M. Binoux, P. Hossenlopp, C. Lassarre, and N. Hardouin, Production of insulin-like growth factors and their carrier by rat pituitary gland and brain explants in primary culture, FEBS Lett 124:178 (1981).

    Article  PubMed  CAS  Google Scholar 

  51. R.P.C. Shiu and J.A. Patterson, Characterization of insulin-like growth factor II peptides secreted by explants of neonatal brain and adult pituitary from rats, Endocrinology 123:1456 (1988).

    Article  PubMed  CAS  Google Scholar 

  52. P. Hossenlopp, D. Seurin, B. Segovia-Quinson, S. Hardouin, and M. Binoux, Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies, Anal Biochem154:138 (1986).

    Article  PubMed  CAS  Google Scholar 

  53. T.L. Wood, A.L. Brown, M.M. Rechler, and J.E. Pintar, The expression pattern of an insulin-like growth factor (IGF)-binding protein gene is distinct from IGF-II in the midgestational rat embryo, Mol Endocrinol 4:1257 (1990).

    Article  PubMed  CAS  Google Scholar 

  54. M.A. Sturm, C.A. Conover, H. Pham, and R.G. Rosenfeld, Insulin-like growth factor receptors and binding protein in rat neuroblastoma cells, Endocrinology 124:388 (1989).

    Article  PubMed  CAS  Google Scholar 

  55. R.H. McCusker, C. Camacho-Hubner, M.L. Bayne, M.A. Cascieri, and D.R. Clemmons, Insulin-like growth factor (IGF) binding to human fibroblast and glioblastoma cells: the modulating effect of cell released IGF binding proteins (IGFBPs), J Cell Physiol 144:244 (1990).

    Article  PubMed  CAS  Google Scholar 

  56. C.A. Conover, Biological actions of insulin-like growth factor binding protein-3 in cultured bovine fibroblasts, Endocrine Society Abstracts72:186A (1990).

    Google Scholar 

  57. V.R. Sara, C. Carlsson-Skwirut, C. Andersson, E. Hall, B. Sjogren, A. Holmgren, and H. Jornvall, Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I, Proc Natl Acad Sci USA 83:4904 (1986).

    Article  PubMed  CAS  Google Scholar 

  58. C. Carlsson-Skwirut, M. Lake, M. Hartmanis, K. Hall, and V.R. Sara, A comparison of the biological activity of the recombinant intact and truncated insulin-like growth factor 1 (IGF-1), Biochim Biophys Acta1011:192 (1989).

    Article  PubMed  CAS  Google Scholar 

  59. C.J. Bagley, B.L. May, L. Szabo, P.J. McNamara, M. Ross, G.L. Francis, F.J. Ballard, and J.C. Wallace, A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide, Biochem J 259:665 (1989).

    PubMed  CAS  Google Scholar 

  60. F. Beck, N.J. Samani, S. Byrne, K. Morgan, R. Gebhard, and W.J. Brammar, Histochemical localization of IGF-I and IGF-II mRNA in the rat between birth and adulthood, Development 104:29 (1988).

    PubMed  CAS  Google Scholar 

  61. P. Rotwein, S.K. Burgess, J.D. Milbrandt, and J.E. Krause, Differential expression of insulin-like growth factor genes in rat central nervous system, Proc Natl Acad Sci USA 85:265 (1988).

    Article  PubMed  CAS  Google Scholar 

  62. L.J. Murphy, G.I. Bell, and H.G. Friesen, Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat, Endocrinology 120:1279 (1987).

    Article  PubMed  CAS  Google Scholar 

  63. G.K. Haselbacher, M.E. Schwab, A, Pasi, and R.E. Humbel, Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms, Proc Natl Acad Sci USA82:2153 (1985).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology and Medicine, Brown University, Providence, RI, USA

    Ian Ocrant

  2. Department of Pediatrics, Rhode Island Hospital, Providence, RI, USA

    Ian Ocrant

Authors
  1. Ian Ocrant
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

  2. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Ocrant, I. (1991). Insulin-Like Growth Factor Binding Proteins in the Nervous System. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_42

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5949-4_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5951-7

  • Online ISBN: 978-1-4684-5949-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation