Abstract
Acidic amino acids, such as glutamate (Glu) and aspartate (Asp), are suggested to be excitatory transmitters in the visual cortex (Clark and Collins, 1976; Baughman and Gilbert, 1981; Tsumoto et al. 1986). Recent studies have demonstrated that synaptic receptors for Glu/Asp can be classified into at least three types, on the basis of their most sensitive agonists, i.e., 1) N-methylD-aspartate (NMDA)-preferring receptors, 2) kainate-preferring receptors and 3) quisqualatepreferring receptors (see Watkins and Evans, 1981 for review). In CAl area of the hippocampus, NMDA receptors have been shown to play a role in a form of synaptic plasticity, i.e., long-term potentiation (LTP) of synaptic efficacy probably by controlling entry of Ca2+ into postsynaptic sites (Collingridge et al., 1983; see Fagg et al., 1986; Bliss and Lynch, 1988; Cotman and Monagham, 1988 for review). In the cat’s visual cortex, Tsumoto and his associates (Tsumoto et al., 1987, 1988; Hagihara et al., 1988) have reported evidence suggesting that receptors of kainate/quisqualate types (non-NMDA receptors) are involved in geniculo- cortical synaptic transmission while NMDA receptors may play a role in synaptic plasticity in the developing visual cortex.
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Tsumoto, T., Kimura, F., Nishigori, A. (1990). A Role of NMDA Receptors and Ca2+ Influx in Synaptic Plasticity in the Developing Visual Cortex. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_20
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DOI: https://doi.org/10.1007/978-1-4684-5769-8_20
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