Skip to main content

Effects of Nimodipine on the Responses to Cerebral Ischemia in the Mongolian Gerbil

  • Chapter
Oxygen Transport to Tissue XI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 248))

Abstract

Brain ischemia has significant implications to the development of damage in patients undergoing stroke condition. In order to understand the mechanisms involved, a few animal models have been adopted. The Mongolian gerbil, having an incomplete circle of Willis, is widely used as a model for partial or complete ischemia (Levy and Brierley, 1974. Berry et al, 1975. Kobayashi et al, 1977. Mayevsky, 1978. Mies and Hossmann, 1983. Mayevsky et al, 1985). The disturbances of ion homeostasis in the brain under ischemia were recorded by a few groups using an extracellular K+ electrode and more recently, Ca+ electrode (Branston et al, 1977. Hansen and Zeuthen, 1981. Harris et al, 1981. Choki et al, 1984. Mayevsky et al, 1985. Mayevsky and Zarchin, 1987).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Berry, K., Wisniewski, H.M., Svarzbein, L. and Baez, S. (1975) On the relationship of brain vasculature to production of neurological deficit and morphological changes following acute unilateral common carotid artery ligation in gerbils. J. Neurol. Sci. 25:75–92.

    Article  PubMed  CAS  Google Scholar 

  • Branston, N.M., Strong, A.J., Symon, L. (1977) Extracellular potassium activity evoked potential and tissue blood flow. Relationship during progressive ischemia in baboon cerebral cortex. J. Neurol. Sci. 32:305–321.

    Article  PubMed  CAS  Google Scholar 

  • Choki, J., Greenberg, J., Sclarsky, D. and Reivich, M. (1984) Correlation between brain surface potassium and glucose utilization after bilateral cerebral ischemia in the gerbil. Stroke. 15:851–857.

    Article  PubMed  CAS  Google Scholar 

  • Dierking, H., Tegtmeier, F., Holler, M. and Peters, Th. (1987) Effects of Fluonarizine, Nimodipine and Diphenylhydantoine on Ke +, Cae + and DC in the hypoxic cortex of the rat brain in vivo. J.CBF and Metabolism. 7: Supp 1, S156.

    Google Scholar 

  • Farber, J.L. (1981) The role of calcium in cell death. Life Sciences. 29: 1289–1295.

    Article  PubMed  CAS  Google Scholar 

  • Gelmers, H.J. (1987) Nimodipine in ischemic Stroke. Clinical Neuropharmacol. 10:412–422.

    Article  CAS  Google Scholar 

  • Hansen, A.J. and Zeuthen, T. (1981) Extracellular ion concentration during spreading depression and ischemia in the rat brain cortex. Acta. Physiol. Scand. 113:437–445.

    Article  PubMed  CAS  Google Scholar 

  • Harris, R.J., Symon, L., Branston, N.M. and Bayhan, M. (1981) Changes in extracellular calcium activity in cerebral ischemia. J.CBF and Metabolism. 1:203–209.

    CAS  Google Scholar 

  • Heffez, D.S. and Passonneau, J.V. (1985) Effet of Nimodipine on cerebral metabolism during ischemia and recirculation in the Mongolian gerbil. J.CBF and Metabolism. 5:523–528.

    CAS  Google Scholar 

  • Kobayashi, M., Lust, W.D. and Passonneau, J.V. (1977). Concentrations of energy metabolites and cyclic nucleotides during after bilateral ischemia in the gerbil cerebral cortex. J.Neurochem. 29:53–59.

    Article  PubMed  CAS  Google Scholar 

  • Levy, D.E. and Brierley, J.B. (1974) Communications between vertebrobasilar and carotid arterial circulations in the gerbil. Exp. Neurol. 45: 503–508.

    Article  PubMed  CAS  Google Scholar 

  • Mayevsky, A. (1978) Pyridine nucleotide oxidation-reduction state of the cerebral cortex in the awake gerbil. J.Neurosci.Res. 3:369–374.

    Article  PubMed  CAS  Google Scholar 

  • Mayevsky, A. (1978) Shedding light on the awake brain. In P.L. Dutton, J. Leigh and A. Scarpa. (eds) Frontiers in Bioenergetics from Electrons to Tissues. Vol. II. Academic Press, New York, pp.1467–1476.

    Google Scholar 

  • Mayevsky, A. (1984) Brain NADH redox state monitored in vivo by fiber optic surface fluorometry. Brain. Res. Rev. 7:49–68.

    Article  CAS  Google Scholar 

  • Mayevsky, A. and Zarchin, N. (1981) The effects of unilateral carotid occlusion on the responses to decapitation in the gerbil brain. Brain Research. 206:155–160.

    Article  PubMed  CAS  Google Scholar 

  • Mayevsky, A. and Chance, B. (1982) Intracellular oxidation reduction state measured in situ by multichannel fiber-optic-surface fluorometer. Science. 217:527–540.

    Article  Google Scholar 

  • Mayevsky, A. and Zarchin, N. (1987) Metabolic Ionic and electrical activities during and after incomplete or complete cerebral ischemia in the Mongolian gerbil. In: Oxygen Transport to Tissue IX, Silver, I.A. and Silver, A. (eds). Plenum Publishing Corp. pp.265–273.

    Google Scholar 

  • Mayevsky, A., Friedli, C.M. and Reivich, M. (1985) Metabolic, ionic and electrical responses of the gerbil brain to ischemia. Am.J.Physiol. 248:R99–R107.

    PubMed  CAS  Google Scholar 

  • Mayevsky, A., Yoles, E. and Zarchin, N. (1986) Metabolic, ionic and electrical responses to oxygen deficiency in the newborn dog in vivo. In: Oxygen Transport to tissue VIII, I.S. Longmuir (ed). Plenum Press. pp. 261–269.

    Google Scholar 

  • Mies, G. and Hossmann, K.A. (1983) A method for regional evaluation of potassium depletion during graded focal ischemia in gerbils. J.CBF and Metabolism.,3, Suppl. 1. S313–314.

    Google Scholar 

  • Milde, L.N., Milde, J.H. and Michenfelder, J.D. (1986) Delayed treatment with Nimodipine improves cerebral blood flow after complete cerebral ischemia in the dog. J.CBF and Metabolism. 6:332–337.

    CAS  Google Scholar 

  • Mori, K. Iwayama, K., Kawano, T., and Kaminogo, M. (1987) DC ptoential and extracellular K+ and Ca2+ at critical levels of brain ischemia in cats. J.CBF and Metabolism. 7, Suppl. 1, S112.

    Google Scholar 

  • Nowicki, J.P. Mackenzie, E.T. Young, A.R. (1982) Brain ischemia, calcium and calcium antagonists. Patholo.Biol. (Paris) 30:282–288.

    CAS  Google Scholar 

  • SiesjO, B.K. (1981) Cell damage in the brain: a speculative synthesis. J.CBF and Metabolism. 1:155–185.

    CAS  Google Scholar 

  • Vibulsresth, S. Dietrich, W.D., Busto, R. and Ginsberg, M.D. (1987) Failure of Nimodipine to prevent ischemic Neuronal damage in rats. Stroke. 18:210–216.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Cohen, S., Mayevsky, A. (1989). Effects of Nimodipine on the Responses to Cerebral Ischemia in the Mongolian Gerbil. In: Rakusan, K., Biro, G.P., Goldstick, T.K., Turek, Z. (eds) Oxygen Transport to Tissue XI. Advances in Experimental Medicine and Biology, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5643-1_48

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5643-1_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5645-5

  • Online ISBN: 978-1-4684-5643-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics