Abstract
Numerous Phase II and Phase III trials have demonstrated that combinations of folinic acid plus 5-FU or sequential methotrexate, 5-FU, folinic acid are effective treatments for patients with advanced carcinoma of the colon or rectum (1–10). In many of these studies the objective response rates in previously untreated patients were greater than 30%. These rates are in excess of those expected for treatment with 5-FU alone (11) suggesting that these combinations are more effective than 5-FU for treatment of patients with advanced colorectal carcinomas.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D. Machover, E. Goldschmit, P. Chollet, et al: Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid, JL Clin. Oncol. 4: 685–698, (1986).
P. Bryne, F. Smith, M.W. Treat, et al: 5-Fluorouracil and higher dose folinic acid treatment of colorectal carcinoma patients, Proc. ASCO 2: 121, (1983).
G.T. Budd, T.R. Fleming, J.D. Bukowski, et al., 5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer: A randomized comparison, J. Clin. Oncol. 5: 272–277, (1987).
J.D. Hines, M.H. Zakem, D.J. Adelstein, et al., Treatment of advanced-stage colorectal adenocarcinoma with fluorouracil and high-dose leucovorin calcium: A pilot study, a. Clin. Oncol. 6: 142–146, (1988).
C. Erlichman, S. Fine, A. Wong, et al., A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma, 2. Clin. Oncol. 6: 469–475, (1988).
J.H. Doroshow, M. Bertrand, E. Newman, et al., Preliminary analysis of a randomized comparison of 5-fluorouracil vs 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer, NCI Monographs 5: 171–174, (1987).
R. Hermann, J. Spehn, J.H. Beyer, et al: Sequential methotrexate and 5-fluorouracil: Improved response rate in metastatic colorectal cancer, a. Clin. Oncol. 2: 591–594, (1984).
N.E. Kemeny, T. Ahmed, R.A. Michaelson, et al., Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma: Attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate, 2. Clin. Oncol., 2: 311–315, (1984).
B.A. Leone, A. Romero, M.G. Rabinovich, et al., Sequential therapy with methotrexate and 5-fluorouracil in the treatment of advanced colorectal carcinoma, 2. Clin. Oncol., 4: 23–27, (1986).
R.J. Ignoffo, M.A. Friedman, M. Gribble, et al., Phase II study of sequential methotrexate and 5-FU plus mitomycin and leucovorin in patients with disseminated large bowel cancer: Northern California Oncology Group Study, Cancer Treat. Rep. 68: 983–988, (1984).
C.G. Moertel, Chemotherapy of gastrointestinal cancer. New Engl. J. Med. 299: 1049, (1978).
F.H. Valone, M. Kohler, K. Fisher, et al, A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuridine alone, NCI Monographs 5: 175–177, (1987).
W. Hryiuk, The impact of dose intensity on the design of clinical trials, Seminars Oncol. 14: 65–74, (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Valone, F.H., Wittlinger, P.S., Flam, M.S., Drakes, T., Eisenberg, P.D., Hannigan, J. (1988). A Northern California Oncology Group Randomized Trial of Single Agent 5-FU vs. High-Dose Folinic Acid + 5-FU vs. Methotrexate + 5-FU + Folinic Acid in Patients with Disseminated Measurable Large Bowel Cancer. In: Rustum, Y., McGuire, J.J. (eds) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology, vol 244. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5607-3_20
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5607-3_20
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-5609-7
Online ISBN: 978-1-4684-5607-3
eBook Packages: Springer Book Archive