Abstract
Viruses can cause immunosuppression by a variety of mechanisms. Immu nosuppression can occur as a result of direct or indirect effects of the virus on various leukocyte populations(1–5) In the case of direct effects, viruses may infect and destroy the specific leukocytes involved in the development and expression of immunity. In addition, viral components that can be released into the extracellular environment may interact directly with specific cells and affect either accessory or effector cell functions.(6) Indirect effects can be produced by the release of mediators, such as hormones, complement, or prostaglandins. (7–9) Inhibition of mediator release following viral infection can also reduce cellular reactivity and subsequent development of immunity.(10–12) In some instances, immunosuppression is confined to the specific antigen(s) causing the suppression, whereas in other instances there is generalized immunosuppression to a wide variety of antigens.(3,13) Thus, it is clearly evident that the phenomenon of virus-induced immunosuppression can occur via a wide variety of different pathways, and in many cases a combination of factors aDDears to act in concert.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abramson, J. S., G. S. Gibrik, E. L. Mills, and P. Quie, Polymorphonuclear leukocyte dysfunction during influenza virus infection in cinchillas, J. Infect. Dis. 143:836–846 (1981).
Astry, G. L. and G. J. Jakab, Influenza virus induced immune complexes suppress macrophage phagocytosis, J. Virol. 50:287–292 (1984).
Wainberg, M. A., S. Vydelingum, and R. G. Margolese, Viral inhibition of lymphocyte mitogenesis: Interference with synthesis and functionally active T cell growth factor (TCGF) activity and reversal of inhibition by the addition of the same, J. Immunol. 130:2372–2378 (1983).
Casali, P., G. P. Price, and M. B. A. Oldstone, Viruses disrupt functions of human lymphocytes: Effects of measles virus and influenza virus on lymphocyte-mediated kill ing and antibody production, J. Exp. Med. 159:1322–1377 (1984).
Forman, A. J., and L. A. Babiuk, Effect of infectious bovine rhinotracheitis virus infection on bovine alveolar macrophage function, Infect. Immun. 35:1041 -1047 (1982).
Jakab, G. J., Viral bacterial interactions in respiratory tract infections: A review of the mechanisms of virus-induced suppression of pulmonary antibacterial defenses, in: Bovine Respiratory Disease, A Symposium (R. W. Loon, ed.), pp. 223–286, Texas A & M University Press, College Station, Texas (1984).
Crabtree, G. R., S. Gillis, K. A. Smith, and A. Munck, Mechanisms of glucocorticoid-induced immunosuppression: Inhibitory effects on expression of Fc receptors and production of T cell growth factors, J. Steroid Biochem. 12:445–449 (1980).
Egwang, T. G., and A. D. Befus, The role of complement in the induction and regulation of the immune response, Immunology 51:207–224 (1984).
Walker, C., F. Kristensen, F. Bettens, and A. L. deWeck, Lymphokine regulation of activated (Gl) lymphocytes. I. Prostaglandin E2-induced inhibition of interleukin 2 production, J. Immunol. 130:1770–1773 (1983).
Jaffe, M. I., and A. R. Rabson, Defective helper factor (LMF) production in patients with acute measles infection, Clin. Immunol. Immunopathol. 20:215–223 (1981).
McGuire, R. L., and L. A. Babiuk, Evidence for defective neutrophil functions in calves exposed to infectious bovine rhinotracheitis, Vet. Immunol. Immunopathol. 5:259–271 (1984).
Schorlemmer, H. U., and A. C. Allison, Effects of activated complement components on enzyme secretion by macrophages, Immunology 31:781–788 (1976).
Von Pirquet, C. E., Das verhalten der kautanen tuberculinreaktion wahrend der masern, Dtsch. Med. Wopchenschi Wochenschrl. 34:1297–1300 (1908).
Gibbs, E. P. J. and M. M. Reyweyemamu, Bovine herpesvirus. I. Bovine herpesvirus-1, Vet. Bull. 47:317–323 (1977).
Homan, E. J., and B. C. Easterday, Isolation of bovine herpesvirus-1 from trigeminal ganglia of clinically normal cattle, Am. J. Vet. Res. 41:1212–1216 (1980).
Baxter, G. M., Neonatal meningoencephalitis associated with IBR virus, Bovine Pract. 19:41–44 (1984).
Hill, B. D., M. W. M. Hill, Y. S. Chung, and R. J. Whittle, Meningoencephalitis in calves due to bovine herpesvirus type 1 infection, Aust. Vet. J. 61:242–243 (1984).
Babiuk, L. A., R. C. Wardley, and B. T. Rouse, Defense mechanisms against bovine herpesviruses: Relationship of virus-host cell events to susceptibility to antibody-complement lysis, Infect. Immun. 12:958–963 (1975).
Rouse, B. T., and L. A. Babiuk, Host defence mechanisms against infectious bovine rhinotracheitis virus. I. In vitro stimulation of sensitized lymphocytes by virus antigen, Infect. Immun. 10:681–687 (1975).
Rouse, B. T. and L. A. Babiuk, Host defence mechanisms against infectious bovine rhinotracheitis virus. II. Inhibition of viral plaque formation by immune peripheral blood lymphocytes, Cell. Immunol. 17:43–46 (1975).
Rouse, B. T., and L. A. Babiuk, Host defence mechanisms against infectious bovine rhinotracheitis virus. III. Isolation and immunological activities of bovine T lymphocytes, J. Immunol. 113:1391–1398 (1975).
Rouse, B. T., and L. A. Babiuk, The direct antiviral cytotoxicity by bovine lymphocytes is not restricted by genetic incompatibility of lymphocytes and target cells, /. Immunol. 118:618–624 (1977).
Wardley, R. C., B. T. Rouse, and L. A. Babiuk, Antibody dependent cytotoxicity mediated by neutrophils as a possible mechanism of antiviral defense, J. Reticuloendothel. Soc. 19:323–332 (1976).
Rouse, B. T., L. A. Babiuk, and Y. Fujimiya, Enhancement of antibody dependent cell cytotoxicity of herpesvirus infected cells by complement, Infect. Immun. 18:660–665 (1977).
Rouse, B. T., A. S. Grewal, and L. A. Babiuk, Complement enhances antiviral antibody dependent cell cytotoxicity, Nature (Lond.) 226:456–458 (1977).
Grewal, A. S., B. T. Rouse, and L. A. Babiuk, Mechanisms of recovery from viral infections: Destruction of infected cells by neutrophils and complement, J. Immunol. 124:312–319 (1980).
Grewal, A. S., and L. A. Babiuk, Complement dependent polymorphonuclear neu trophil mediated cytotoxicity of herpesvirus infected cells: Possible mechanisms of cytotoxicity, Immunology 40:151 -161 (1980).
Babiuk, L. A., and B. T. Rouse, Interaction between effector cell activity and lympho-kines: Implications for recovery from herpesvirus infections, Int. Arch. Allergy App. Immunol. 57:62–73 (1978).
Babiuk, L. A., H. Bielefeldt Ohmann, G. Gifford, C. Czarniecki, V. T. Scialli, and E. B. Hamilton, Effect of bovine-1 interferon on bovine herpesvirus-1 induced respiratory disease, J. Gen. Virol. 66:2838–2894 (1985).
Bielefeldt Ohmann, H., and L. A. Babiuk, Viral bacterial pneumonia in calves: Effect of bovine herpesvirus-1 on immunological functions, J. Infect. Dis. 151:937–947 (1985).
Babiuk, L. A., and B. T. Rouse, Immune interferon production by lymphoid cells: Role in the inhibition of herpesvirus, Infect. Immun. 13:1567–1578 (1976).
Splitter, G. A., L. Eskra, M. Miller-Edge, and J. L. Splitter, Bovine herpesvirus: Interactions between animal and virus, CRC Comparative Pathobiology of Viral Diseases ,Vol. 1, pp. 57-88 (R. G. Olsen, S. Krakawka, and J. R. Blakesley, eds.), CRC Press, Boca Raton, Florida (1984).
Gershon, R. K., and K. Kondo, Cell interactions in the induction of tolerance: The role of thymic lymphocytes, Immunology 18:723–737 (1970).
Rich, R. R., and C. W. Pierce, Biological expressions of lymphocyte activation: Effects of phytomytogens on antibody synthesis in vitro, J. Exp. Med. 137:205–223 (1973).
Tada, T., and T. Takemori, Selective roles of thymus derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specifíc IgM and IgG antibody responses, J. Exp. Med. 140:239–252 (1974).
Klein, J., Immunology the Science of Self-Nonself Discrimination ,Wiley, New York (1982).
Herbert, A. G., and J. D. Watson, T-cell ontogeny: The role of a stimulator suppressor cell, Immunol. Today 7:72–76 (1986).
Bensussan, A., O. Acuto, R. E. Hussey, C. Milanese, and E. L. Reinherz, T3-Ti receptor triggering of T8 + suppressor T cells leads to immunoresponsiveness to interleukin-2, Nature (Lond) 311:565–567 (1984).
Kasakura, S., M. Taguchi, Y. Watanabe, T. Okubo, T. Murachi, H. Uchino, and M. Hanaoka, Suppressor cell induction factor: A new mediator released by stimulated human lymphocytes and distinct from previously described lymphokines, J. Immunol. 130:2720–2726 (1983).
Horohov, D. W., J. H. Wyckoff, R. N. Moore, and B. T. Rouse, Regulation of herpesvirus simplex virus-specific cell-mediated immunity by a specific suppressor factor, J. Virol. 58:331–338 (1986).
Bielefeldt Ohmann, H., L. G. Filion, and L. A. Babiuk, Bovine monocytes and macrophages: An accessory role in suppressor-cell generation by Con A and in lectin-in-duced proliferation, Immunology 50:189–197 (1983).
Filion, L. G., R. L. McGuire, and L. A. Babiuk, Non-specific suppressive effect of bovine herpesvirus-1 on bovine leukocyte functions, Infect. Immun. 42:106–112 (1983).
Ceredig, R., and G. Corradin, High antigen concentration inhibits T cell proliferationbut not interleukin 2 production: Examination of limiting dilution microcultures and T cell clones, Eur. J. Immunol. 16:30–34 (1986).
Miller-Edge, M. A., T-cell mediated immune responses to bovine herpesvirus 1: The role of interleukin-2, in: Characterization of the Bovine Interferon Immune System and the Genes Regulating Expression of Immunity with Particular Reference to Their Role in Disease Resistance: A Symposium (W. C. Davis, J. N. Shelton, and C. W. Weems, eds.), pp. 99–118, Washington State University Press, Pullman, Washington (1985).
Rubin, L. A., C. C. Kurman, M. E. Fritz, W. E. Biddison, B. Boutin, R. Yarchoan, and D. L. Nelson, Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro, J. Immunol. 135:3172–3177 (1985).
Splitter, G. A., and L. Eskra, Bovine T lymphocyte response to bovine herpesvirus-1: Cell phenotypes, viral recognition and acid-labile interferon production, Vet. Immunol. Immunopathol. 11:235–250 (1986).
Woodruff, J. F., and J. J. Woodruff, The effect of viral infections on the function of the immune system in: Viral Immunology and Immunopathology (A. L. Notkins, ed.), pp. 393–418, Academic, New York (1975).
Babiuk, L. A. ,and H. Bielefeldt Ohmann, Bovine herpesvirus-1 (BHV-1) infection in cattle as a model for viral induced immunosuppression, in: Viral Mechanisms of Immu nosuppression (M. Kende, J. Gainer, and H. Chirigos, eds.), pp. 99–114, Liss, New York (1985).
Braun, R. W., H. K. Teute, H. Kirchner, and K. Munk, Replication of herpes simplex virus in human T lymphocytes: Characterization of the viral target cell, J. Immunol. 132:914–919 (1984).
Isfort, R. J., R. A. Stringer, H. J. Kung, and L. F. Velicer, Synthesis, processing and secretion of Marek’s disease herpesvirus A antigen glycoprotein, J. Virol. 57:464–474 (1986).
Maes, R. K., S. L. Fritsch, L. L. Herr, and P. A. Rota, Immunogenic proteins of feline rhinotracheitis virus, J. Virol. 51:259–262 (1984).
Okuno, T., K. Yamanishi, K. Shiraki, and M. Takahashi, Synthesis and processing of glycoproteins of varicella-zoster virus (VZV) as studies with monoclonal antibodies to VZV antigens, Virology 129:357–368 (1983).
Rea, T. J., J. G. Timmins, G. W. Lony, and L. E. Post, Mapping and sequence of the gene for the pseudorabies virus glycoprotein which accumulates in the medium of infected cells, J. Virol. 54:21–29 (1985).
Letchworth, G. J. III, and L. E. Carmichael, The effect of temperature on production and function of bovine interferons, Arch. Virol. 82:211–221 (1982).
Aune, T. M., and C. W. Pierce, Identification and initial characterization of a nonspecific suppressor factor produced by soluble immune response suppressor-treated macrophages, J. Immunol. 127:1828–1833 (1981).
Schnaper, H. W., Identification and initial characterization of concanavalin A-and interferon-induced human suppressor factors: Evidence for a human equivalent of murine soluble immune response suppressor (SIRS), J. Immunol. 132:2429–2436 (1984).
Lipscomb, M. F., G. B. Toews, G. R. Lyons, and J. W. Uhr, Antigen presentation by guinea pig alveolar macrophages, J. Immunol. 126:286–292 (1981).
Towes, G. B., W. C. Vial, and M. M. Dunn, The accessory cell function of human alveolar macrophages in specific T cell proliferation, J. Immunol. 132:181 -186 (1984).
Slauson, D. O., The mediation of pulmonary inflammatory injury, Adv. Vet. Sci. Compar. Med. 26:99–120 (1982).
Bielefeldt Ohmann, H., and L. A. Babiuk, Alteration of some leukocyte functions following in vivo and in vitro exposure to recombinant bovine alpha-and gamma-interferon, J. Interferon Res. 6:123–136 (1986).
Holt, P. G., Alveolar macrophages. II. Inhibition of lymphocyte proliferation by peripheral macrophages from rat lung, Immunology 37:429–436 (1979).
Holt, P. G., Alveolar macrophages. III. Studies on the mechanism of inhibition of T-cell proliferation, Immunology 37:437–445 (1979).
Yeager, H., Jr., J. A. Sweeney, H. B. Herscowitz, I. S. Barsaum, and E. Kagan, Modula tion of mitogen induced proliferation of autologous peripheral blood lymphocytes by human alveolar macrophages, Infect Immun. 38:260–266 (1982).
Lawrence, E. C., G. J. Theodore, and R. R. Martin, Modulation of pokeweed mitogen induced immunoglobulin secretion by human bronchoalveolar cells, Am. Rev. Respir. Dis. 126:248–252 (1982).
Twomey, J. J., A. Laughter, and M. F. Brown, A comparison of the regulatory effects of human monocytes, pulmonary alveolar macrophages (PAMs) and spleen macrophages upon lymphocyte responses, Clin. Exp. Immunol. 52:449–545 (1983).
Rinehart, J. J., M. Orser, and M. E. Kaplan, Human monocyte and macrophage modulation of lymphocyte proliferation, Cell. Immunol. 44:131–143 (1979).
Rice, L., A. H. Laughter, and J. J. Twomey, Three suppressor systems in human blood that modulate lymphoproliferation, J. Immunol. 122:991–996 (1979).
Liu, M. C., Human lung macrophages enhance and inhibit lymphocyte proliferation, J. Immunol. 132:2895–2904 (1984).
Bendixen, P. H., P. E. Shewen, and B. N. Wilkie, The influence of bovine alveolar macrophages on the blastogenic response of peripheral blood mononuclear cells, in: The Ruminant Immune System (J. E. Butler, ed.), p. 814, Plenum, New York (1981).
Goldyne, M. E., and J. D. Stobo, Immunoregulatory role of prostaglandins and related lipids, CRC Crit. Rev. Immunol. 2:189–242 (1981).
Hasler, F., H. G. Bluestein, N. J. Zvaifler, and L. B. Epstein, Analysis of the defects responsible for impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E, Eur. J. Immun. 131:768–774 (1983).
Kunkel, S. L., D. A. Cambell, S. W. Chensue, and G. I. Higashi, Species-dependent regulation of monocyte-macrophage Ia antigen expression and antigen presentation by prostaglandin E, Cell. Immunol. 97:140–152 (1986).
Dinarello, C. A., Human interleukin-1. The importance of its multiple activities for immunoregulation, in: Sixth International Congress on Immunology (B. Cinader and R. G. Miller, eds.), p. 41, Academic Press, Toronto (1986).
Albrightson, G. R., N. L. Baenziger, and P. Needleman, Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: Role of monokines and interleukin 1, J. Immunol. 135:1872–1877 (1985).
Chouaib, S., L. Chatenoud, D. Klatzmann, and D. Fradelizi, The mechanisms of inhibition of human IL-2 production II. PGE-2 induction of suppressor T lymphocytes, J. Immunol. 132:1851–1857 (1984).
Oppenheim, J. J., E. J. Kovacs, K. Matsushima, and S. K. Durum, There is more than one interleukin 1, Immunol. Today 7:45–56 (1986).
Roberts, N. J., A. H. Prill, and T. N. Mann, Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitory activity, J. Exp. Med. 163:511–520 (1986).
Weitzman, S. A., and T. P. Stossel, Mutation caused by human phagocytes, Science 212:546–547 (1981).
Carson, D. A., S. Seto, and D. B. Wasson, Lymphocyte dysfunction after DNA damage by toxic oxygen species: A model of immunodeficiency, J. Exp. Med. 163:746–752 (1986).
Rodrick, M. L., I. B. Lamster, S. T. Sonis, S. G. Pender, A. B. Kolodkin, J. E. Fitzgerald, and R. E. Wilson, Effect of supernatants of polymorphonuclear neutrophils recruited by different inflammatory substances on mitogen responses of lymphocytes, Inflammation 6:1–11 (1982).
Yoshinaga, M., K. Nishime, S. Nakamura, and F. Goto, A PMN-derived factor that enhances DNA-synthesis in PHA or antigen-stimulated lymphocytes, J. Immunol. 124:94–99 (1980).
Hsu, C. C., M. B. Wu, and J. Rivera-Arcilla, Inhibition of lymphocyte reactivity in vitro by autologous polymorphonuclear cells (PMN), Cell Immunol 48:288–295 (1979).
Starke, I. D., Granulocyte content and titrated thymidine uptake of mononuclear cells, preparations from patients with ovarian cancer, Clin. Oncol. 8:243–249 (1982).
Judson, D. G., and J. B. Dixon, Depression of lymphocyte reactivity by granulocytes in equine whole blood culture, Vet. Immunol. Immunopathol. 8:289–295 (1985).
Tiku, K., M. L. Tiku, S. Liu, and J. L. Skosey, Normal human neutrophils are a source of a specific interleukin 1 inhibitor, J. Immunol. 136:3686–3692 (1986).
Blecha, F., and P. E. Baker, Effect of Cortisol in vitro and in vivo on production of bovine interleukin 2, Am. J. Vet. Res. 47:841–845 (1986).
Emery, D. L., J. H. Duffy, and P. R. Wood, An analysis of cellular proliferation and production of lymphokines and specific antibody in vitro by leukocytes from immunized cattle, in: First International Veterinary Immunology Symposium (B. Wilkie, P. E. Shewan, K. Nielson, J. R. Duncan, and B. W. Stemshorn, eds.), p. 57, University of Guelph Press, Guelph, Ontario (1986).
Blalock, J. E., Production and action of lymphocyte-derived neuroendocrine peptide hormones: A summary, in: Sixth International Congress on Immunology (B. Cinader and R. G. Miller, eds.), p. 48, Academic Press, Toronto (1986).
Blecha, F., and H. C. Minocha, Suppressed lymphocyte blastogenic responses and en hanced in vitro growth of bovine rhinotracheitis virus in stressed feeder calves, Am. J. Vet. Res. 44:2145–2148 (1983).
Payan, D. G., and E. J. Goetzl, Modulation of lymphocyte function by sensory neuropeptides, in: Neuromodulation of Immunity and Hypersensitivity, J. Immunol. 135(suppl.):783–786 (1985).
Payan, D. G., J. D. Levine, and E. J. Goetzl, Modulation of immunity and hypersensitivity by sensory neuropeptides, J. Immunol. 132:1601–1604 (1984).
Smith, E. M., D. Harbour-McMenamin, and E. J. Blalock, Lymphocyte production of endorphins and endorphin-mediated immunoregulatory activity, in: Neuromodulation of Immunity and Hypersensitivity, J. Immunol. 135(suppl.):779–782 (1985).
Johnson, H. M.. E. M. Smith, B. A. Torres, and J. E. Blalock, Neuroendocrine hormone regulation of an in vitro antibody production, Proc. Natl. Acad. Sci. USA 79:4171–4174 (1982).
Brock, J. H., and M. DeSousa, Immunoregulation by iron-binding proteins, Immunol. Today 7:30–31 (1986).
Lum, J. F., A. J. Infante, D. M. Makker, F. Yang, and B. H. Bowman, Transferrin synthesis by inducer T lymphocytes, J. Clin. Invest. 77:841–850 (1986).
Matzner, Y., C. Hershko, A. Polliack, A. M. Konijn, and G. Izak, Suppressive effect of ferritin on in vitro lymphocyte function, Br. J. Haematol. 42:345–353 (1979).
Gleeson, L. J., and L. Coggins, Equine herpesvirus type 2: Cell-virus relationship during persistent cell associated viremia, Am. J. Vet. Res. 46:19–23 (1986).
Dutta, S. K., and A. C. Myrup, Infectious center assay of intracellular virus and infective virus titer for equine mononuclear cells infected in vivo and in vitro with equine herpesvirus, Can. J. Compar. Med. 47:64–69 (1983).
Coignoul, F. L., T. A. Bertram, and N. F. Cheville, Functional and ultrastructural changes in neutrophils from mares and foals experimentally inoculated with a respiratory tract strain of equine herpesvirus-1, Am. J. Vet. Res. 45:1972–1975 (1984).
Dutta, S. K., Myrup, A. and M. K. Bumgardner, Lymphocyte responses to virus and mitogen in ponies during experimental infection with equine herpesvirus-1, Am. J. Vet. Res. 41:2066–2068 (1980).
Scott, J. C., S. K. Dutta, and A. C. Myrup, In vivo harboring of equine herpesvirus-1 in leukocyte populations and subpopulations and their quantitation from experimentally infected ponies. Am. J. Vet. Res. 44:1344–1348 (1983).
Wittman, G., V. Ohlinger, and H. J. Rziha, Occurrence and reactivation of latent Aujesky’s disease virus following challenge in previously vaccinated pigs, Arch. Virol. 75:29–41 (1983).
Narita, M., S. Inui, and Y. Shimizu, Tonsillar changes in pigs given pseudorabies (Aujesky’s disease) virus. Am. J. Vet. Res. 45:247–251 (1984).
Smid, B., L. Valick, and A. Sabol, Morphogenesis of Aujesky’s disease virus in pig lung macrophages, Acta Vet. Brno 50:79–87 (1981).
Jakowski, R. M., T. N. Fredrickson, T. W. Chomiak, and R. E. Luginbuhl, Hema topoietic destruction in Marek’s disease, Avian Dis. 14:374–383 (1970).
Witter, R. L., J. M. Sharma, and A. M. Fadley, Pathogenicity of variant Marek’s disease virus isolates in vaccinated and unvaccinated chickens, Avian Dis. 24:210–219 (1980).
Longenecker, B. M., F. Pazderka, J. S. Gavora, J. L. Spencer, E. A. Stephens, and R. L. Witter, Role of major histocompatability complex in resistance to Marek’s disease: Restriction of growth of JMV-MD tumor cells in genetically resistant birds, Adv. Exp. Med. Biol. 88:287–296 (1977).
Briles, W. E., R. W. Briles, W. H. McGibbon, and H. A. Stone, Identification of B alloalleles associated with resistance to Marek’s disease, pp. 395-416, in: Resistance and Immunity to Marek’s Disease (P. M. Biggs, ed.), CEC Publication Eur 6470, Luxembourg (1982).
Calnek, B. W., J. C. Carlisle, J. Fabricant, K. K. Murthy, and K. A. Schat, Comparative pathogenesis studies with oncogenic and nononcogenic Marek’s disease virus and turkey herpesvirus, Am. J. Vet. Res. 40:541–548 (1979).
Schierman, L. W.. G. A. Theis, and R. A. McBride, Preservation of a T cell mediated immune response in Marek’s disease virus-infected chickens by vaccination with a related virus, J. Immunol 116:1497–1507 (1976).
Powell, P. C., In vitro stimulation of blood lymphocytes by phytohemagglutinin during the development of Marek’s disease, Avian Pathol. 9:471–485 (1980).
Shek, W. R., B. W. Calnek, K. A. Schat, and C. H. Chen, Characterization of Marek’s disease virus-infected lymphocytes: Discrimination between cytolytically and latently infected cells, J. Natl. Cancer Inst. 70:485–491 (1983).
Lee, L. F., J. M. Sharma, K. Nazerian, and R. L. Witter, Suppression and enhancement of mitogen response in chickens infected with Marek’s disease virus and herpesvirus of turkeys, Infect. Immun. 21:474–479 (1978).
Schierman, L. W., G. A. Theis, and R. A. McBride, Preservation of a T cell mediated immune response in Marek’s disease virus-infected chickens by vaccination with a related virus, J. Immunol. 116:1497–1499 (1976).
Wainberg, M. A., B. Beiss, and E. Israel, Viral-mediated abrogation of chicken lymphocyte responsiveness to mitogenic stimulus, Avian Dis. 24:580–591 (1980).
Lee, L. F., J. M. Sharma, K. Nazerian, and R. C. Witter, Suppression of mitogen induced proliferation of normal spleen cells by macrophages from chickens inoculated with Marek’s disease virus, J. Immunol. 120:1554–1559 (1978).
Theis, G. A., Subpopulations of suppressor cells in chickens infected with cells of a transplantable lymphoblastic leukemia, Infect. Immun. 34:526–534 (1981).
Theis, G. A., Effect of lymphocytes from Marek’s disease infected chickens on mitogenic responses of syngeneic normal chicken spleen cells, J. Immunol. 118:887–894 (1977).
Calnek, B. W., K. J. Fahey, and T. J. Bagust, In vitro infection studies with infectious laryngotracheitis virus, Avian Dis. 30:327–336 (1986).
Chang, P. W., F. Sculco, and V. J. Yates, An in vivo and in vitro study of infectious laryngotracheitis virus in chicken leukocytes, Avian Dis. 21:492–500 (1977).
Bagust, T. J., B. W. Calnek, and K. J. Fahey, Gallid-1 herpesvirus infection in the chicken. 3. Reinvestigation of the pathogenesis of infectious laryngotracheitis in acute and early post-acute disease, Avian Dis. 30:179–190 (1986).
Stevens, J. G., and M. L. Cook, Restriction of herpes simplex virus by macrophages: An analysis of cell-virus interaction, J. Exp. Med. 13:19–38 (1971).
Cross, S. S., J. C. Parker, W. C. Rowe, and M. L. Robbins, Biology of mouse thymic virus, a herpesvirus of mice and the antigenic relationship to mouse cytomegalovirus, Infect. Immun. 26:1186–1195 (1979).
Cohen, P. L., S. S. Cross, and D. E. Mosier, Immunologic effects of neonatal infection with mouse thymic virus, J. Immunol. 115:706–710 (1975).
Griffith, B. P. and G. D. Hsiung, Persistence and expression of herpesvirus in guinea pig B and T cells, Proc. Soc. Exp. Biol. Med. 162:202–206 (1978).
Dowler, K. W., S. McCormick, J. A. Armstrong, and G. D. Hsiung, Lymphoproliferative changes induced by infection with a lymphotropic herpesvirus of guinea pigs, J. Infect. Dis. 150:105–111 (1984).
Tenser, R. B., and G. D. Hsiung, Infection of thymus cells in vivo and in vitro with a guinea pig herpes-like virus and the effect of antibody on virus replication in organ culture, J. Immunol. 110:552–560 (1973).
Gonzalez-Serva, A., and G. D. Hsiung, Expression of herpesvirus in adherent cells from bone marrow of latently infected guinea pigs, Am. J. Pathol. 9:483–496 (1978).
Kramp, W. J. ,P. Medveczky, C. Mulder, H. C. Hinze, and J. L. Sullivan, Herpes sylvilagus infects both B and T lymphocytes in vivo, J. Virol. 56:60–65 (1985).
Arbeit, R. D., J. A. Zaia, M. A. Valerio, and M. J. Levin, Infection of human peripheral blood mononuclear cells by varicella zoster virus, Intervirology 18:56–65 (1982).
Ozaki, T., T. Ichikawa, Y. Matsui, H. Konda, T. Nagain, Y. Asano, K. Yamanishi, and M. Takahashi, Lymphocyte-associated viremia in varicella, J. Med. Virol. 19:249–253 (1986).
Twomey, J. J., F. Gyorkey, and S. M. Norris, The monocyte disorder with herpes zoster, /. Exp. Clin. Med. 83:768–777 (1974).
Arneborn, P. and G. Biberfeld, T lymphocyte subpopulation in relation to immunosup pression in measles and varicella, Infect. Immun. 39:29–37 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Babiuk, L.A., Lawman, M.J.P., Griebel, P. (1989). Immunosuppression by Bovine Herpesvirus 1 and Other Selected Herpesviruses. In: Specter, S., Bendinelli, M., Friedman, H. (eds) Virus-Induced Immunosuppression. Infectious agents and pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5583-0_8
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5583-0_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5585-4
Online ISBN: 978-1-4684-5583-0
eBook Packages: Springer Book Archive