Abstract
Models are intermediate way stations on the road to a complete theory of protein motions and protein dynamics. All roads lead to Rome and many models may contain some of the right ingredients for a successful theory. We can learn from nuclear theory, where apparently contradictory approaches, the liquid drop and the nuclear shell model, were both way stations to a unified description of nuclear dynamics. Here we describe some similarities between proteins and glasses, in particular spin glasses. This similarity does not mean that proteins are glasses but that essential physical characteristics are common. Since many more theorists work in the fields of glasses and spin glasses than in proteins, we may be able to borrow from their results or even entice them to join our efforts. On the other hand, proteins have the advantage of 3 1/2 Gy of R&D and there may be many experiments that can be performed more easily and more reliably with proteins than with glasses. The various fields consequently may be able to progress faster together than individually.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R.H. Austin, K. Beeson, L. Eisenstein, H. Frauenfelder, I.C. Gunsalus and V.P. Marshall, Science, 181, 541 (1973).
F. Stetzkowski, R. Banerjee, M.C. Marden, D.K. Beece, S.F. Bowne, W. Doster, L. Eisenstein, H. Frauenfelder, L. Reinisch, E. Shyamsunder and C. Jung, J. Biol. Chem., 260, 8803 (1985).
“Amorphous Solids,” W.A. Phillips, ed., Springer, Berlin (1981).
F. Mezei, A.P. Murani and J.L. Tholence, Solid State Comm., 45, 411 (1983).
R.V. Chamberlin, G. Mozurkewich and R. Orbach, Phys. Rev. Lett., 52, 867 (1984).
J. Klafter, A. Blumen and G. Zumofen, Phil. Mag., B53, L29 (1986).
R.H. Austin, K.W. Beeson, L. Eisenstein, H. Frauenfelder and I.C. Gunsalus, Biochemistry, 14, 5355 (1975).
H. Frauenfelder, in “Structure & Dynamics: Nucleic Acids & Proteins,” E. Clementi and R.H. Sarma, eds., Adenine Press, Guilderland, New York (1983).
H. Frauenfelder, G.A. Petsko and D. Tsernoglou, Nature, 280, 558 (1979).
P.J. Artimyuk, C.C.F. Blake, D.E.P. Grace, S.J. Oatley, D.C. Phillips and M.J.E. Sternberg, Nature, 280, 563 (1979).
G.A. Petsko and D. Ringe, Ann. Rev. Biophys. Bioeng., 13, 331 (1984).
J. Kuriyan, S. Wilz, M. Karplus and G.A. Petsko, J. Mol. Biol., submitted.
H. Keller and P.G. Debrunner, Phys. Rev. Lett., 45, 68 (1980).
F. Parak, E.N. Frolov, R.L. Mössbauer and V.I. Goldanskii, J. Mol. Biol., 145, 825 (1981).
F. Parak, E.W. Knapp and D. Kucheida, J. Mol. Biol., 161, 177 (1982).
E.R. Bauminger, S.G. Cohen, I. Nowik, S. Ofer and J. Yariv, Proc. Natl. Acad. Sci. USA, 80, 736 (1983).
Yu. Krupyanski, F. Parak, D. Engelman, R.L. Mössbauer, V.I. Goldanskii and I. Suszcheliev, Z. Naturforsch., C.37, 57 (1982).
F.J. Litterst, Nuclear Instr. Meth., 199, 87 (1982).
V.I. Goldanskii, Yu. F. Krupyanski and V.N. Flerov, Doklady Akad. Nauk SSSR, 272, 978 (1983).
G.P. Singh, H.J. Schink, H. von Lohneysen, F. Parak and S. Hunklinger, Z. Phys., B55, 23 (1984).
H. Frauenfelder, “Structure and Motion: Membranes, Nucleic Acids & Proteins,” E. Clementi, G. Corongiu, M.H. Sarma and R.H. Sarma, eds., Adenine Press, Guilderland, New York (1985).
A. Ansari, J. Berendzen, S.F. Bowne, H. Frauenfelder, I.E.T. Iben, T.B. Sauke, E. Shyamsunder and R.D. Young, Proc. Natl. Acad. Sci. USA, 82, 5000 (1985).
S.E.V. Phillips, J. Mol. Biol., 142, 531 (1980).
H. Frauenfelder and P.G. Wolynes, Science, 229, 337 (1985).
W. Bialek and R.F. Goldstein, Biophys. J., 48, 1027 (1985).
V. Srajer, K.T. Schomacker and P.M. Champion, Phys. Rev. Letters, submitted.
A. Cooper, Proc. Natl. Acad. Sci. USA, 73, 2740 (1976).
L. Onsager, Phys. Rev., 37, 405 (1931).
H.B. Callen and T.B. Welton, Phys. Rev., 83, 34 (1951).
L. Onsager and S. Machlup, Phys. Rev., 91, 1505 (1953).
R. Kubo, Progress Phys., 29, 255 (1966).
P. Hänggi, Helv. Phys. Acta, 51, 202 (1979).
J.M. Ziman, “Models of Disorder,” Cambridge Univ. Press (1979).
R. Zalle, “The Physics of Amorphous Solids,” John Wiley, New York (1983).
“Amorphous Solids,” W.A. Phillips, ed., Springer, Berlin (1981).
Heidelberg Colloquium on Spin Glasses. Lecture Notes in Physics 192, J.L. van Hemmen and I. Morgenstern, eds., Springer, Berlin (1983).
G. Toulouse, Comm. Physics, 2, 115 (1977).
D. Stein, Proc. Natl. Acad. Sci. USA, 82, 3670 (1985).
S. Kirkpatrick and D. Sherrington, Phys. Rev., B17, 4384 (1978).
R.G. Palmer, Adv. Phys., 31, 669 (1982).
G. Toulouse, Helv. Phys. Acta, 57, 459 (1984).
M. Mézard, G. Parisi, N. Sourlas, G. Toulouse and M. Virasoro, Phys. Rev. Lett., 52, 1156 (1984).
R.G. Palmer, D.L. Stein, E. Abrahams and P.W. Anderson, Phys. Rev. Lett., 53, 958 (1984).
W. Weber, Annalen der Physik und Chemie (Poggendorf), 34, 147 (1835).
J.T. Bendler, J. Stat. Phys., 36, 625 (1984).
M.F. Shlesinger and E.W. Montroll, Proc. Natl. Acad. Sci. USA, 81, 1280 (1984).
B. Huberman and M. Kerszberg, J. Phys., A18, L331 (1985).
R. Rammal, G. Toulouse and M.A. Virasoro, Rev. Mod. Phys., in press (1986).
A.T. Ogielski and D.L. Stein, Phys. Rev. Lett., 55, 1634 (1985).
S. Teitel and E. Domany, Phys. Rev. Lett., 55, 2176 (1985).
A. Blumen, J. Klafter and G. Zumofen, J. Phys., A19, L77 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Frauenfelder, H. (1986). Proteins and Glasses. In: Clementi, E., Chin, S. (eds) Structure and Dynamics of Nucleic Acids, Proteins, and Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5308-9_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5308-9_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5310-2
Online ISBN: 978-1-4684-5308-9
eBook Packages: Springer Book Archive