Abstract
Mechanical transduction is the most widespread sensory modality in animals. Specialized organs of the cochlea (Hudspeth, 1983) and vestibular system provide our sense of hearing and local gravity. Our sense of touch and vibration, particularly in the skin, is mediated by a variety of specialized mechanosensors and possibly free nerve endings (Iggo and Andres, 1982). Muscle tension is transduced by Ia afferent nerves in muscle spindles, while tendon tension is transduced by Golgi tendon organs. Joint position is transduced by poorly understood receptors in the joint capsule. The inflation of hollow organs is reported by sensory nerves of the autonomic nervous system, although the location of the actual transducers is not known and may reside in nerve cells, muscle cells, or other types of supporting cells. Inflation of blood vessels is used to measure blood pressure. Inflation of the lung, gut, bladder, mammary glands, and probably cerebrospinal fluid all provides essential feedback for autonomic regulation. Osmoregulation at the systemic level and cell volume itself (Kregenow, 1981) are likely to be controlled by feedback from membrane tension.
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References
Auerbach, A., and Sachs, F., 1984, Kinetics and conductance properties of gaps within bursts of nicotinic ion channel activity, Biophys. J. 45:187–198.
Brehm, P., Kullberg, R., and Moody-Corbett, F., 1984, Properties of nonjunctional acetylcholine receptor channels on innervated muscle of Xenopus Laevis, J. Physiol. (Lond.) 350:631–648.
Colquhoun, D., and Hawkes, A. G., 1981, On the stochastic properties of single ion channels, Proc. R. Soc. Lond. [Biol.] 211:205–235.
Corey, D., and Hudspeth, A. J., 1983, Kinetics of the receptor current in bullfrog saccular hair cells, J. Neurosci. 3:962–976.
Edwards, C., 1983, The ionic mechanisms underlying the receptor potential in mechano-receptors, in The Physiology of Excitable Cells (A. D. Grinnel and W. J. Moody, eds.), Alan R. Liss, New York, pp. 497–503.
Edwards, C., Ottoson, D., Rydqvist, B., and Swerup, C., 1981, The permeability of the transducer membrane of the crayfish stretch receptor to calcium and other divalent ions, Neuroscience 6:1455–1460.
Evans, E. A., and Hochmuth, R. M., 1973, Mechano-chemical properties of membrane, in Current Topics in Membrane Transport (F. Bronner and A. Kleinzeller, eds.), Academic Press, New York, pp. 1–64.
Evans, E. A., Waugh, R., and Melnik, L., 1976, Elastic area compressibility modulus of red cell membrane, Biophys. J. 16:585–595.
Gross, D., Williams, W. S., and Connor, J. A., 1983, Theory of electromechanical effects in nerve, Cell. Mol. Neurobiol. 3:89–111.
Guharay, F., and Sachs, F., 1984a, Stretch activated single ion-channel currents in tissue-cultured embryonic chick skeletal muscle, J. Physiol. (Lond.) 352:685–701.
Guharay, F., and Sachs, F., 1984b, Mechano-transducer ion channels in chick skeletal muscle: The effects of extracellular pH, J. Physiol. (Lond.) 363:119–134.
Guharay, F., and Sachs, F., 1985, Mechano-receptor ion channels are not nicotinic, Biophys. J. 47:2039.
Hamill, O. P., 1983, Potassium and chloride channels in red blood cells, in Single-Channel Recording (B. Sakmann and E. Neher, eds.), Plenum Press, New York, pp. 451–471.
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J., 1981, Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches, Pfluegers Arch. 391:85–100.
Helfrich, W., 1973, Elastic properties of lipid bilayers: Theory and possible experiments, Z. Naturforsch. 28C:693–703.
Hudspeth, A. J., 1983, Mechanoelectrical transduction by hair cells in the acousticolateralis sensory system, Annu. Rev. Neurosci. 6:187–215.
Iggo, A., and Andres, K. H., 1982, Morphology of cutaneous receptors, Annu. Rev. Neurosci. 5:1–31.
Kistler, J., Stroud, R. M., Klymkowsky, M. W., Lalancette, R. A., and Fairclough, R. H., 1982, Structure and function of an acetylcholine receptor, Biophys. J. 37:371–383.
Kregenow, F., 1981, Osmoregulatory salt transporting mechanisms: Control of cell volume in anisotropic media, Annu. Rev. Physiol. 43:493–505.
Kwok, R., and Evans, E. A., 1981, Thermoelasticity of large lecithin bilayer vesicles, Biophys. J. 35:637–652.
Lis, L. J., McAlister, M., Fuller, N., Rand, R. P., and Parsegian, V. A, 1982, Measurement of the lateral compressibility of several phospholipid bilayers, Biophys. J. 37:667–672.
Naftalin, L., 1965, Some new proposals regarding acoustic transmission and transduction, Cold Spring Harbor Symp. Quant. Biol. 30:169–180.
Ohmori, H., 1984, Studies of ionic currents in the isolated vestibular hair cell of the chick, J. Physiol. (Lond.) 350:561–581.
O’Leary, D. P., 1970, An electrokinetic model of transduction in the semicircular canal, Biophys. J. 10:859–875.
Sachs, F., 1984, The noise produced by patch electrodes: A model, Biophys. J. 45:57a.
Sachs, F., Neil, J., and Barkakati, N., 1982, Automated analysis of single channel data, Pfluegers Arch. 395:331–340.
Sakmann, B., and Neher, E., 1983, Geometric parameters of pipettes and membrane patches, in Single-Channel Recording (B. Sakmann and E. Neher, eds.), Plenum Press, New York, pp. 37–51.
Teorell, T., 1971, A biophysical analysis of mechano-electrical transduction, in Principles of Receptor Physiology, (W. R. Loewenstein, ed.), Springer-Verlag, New York, pp. 291–339.
Weber, K., and Osborne, M., 1981, Microtubule and intermediate filament networks in cells viewed by immunofluorescence microscopy, in Cytoskeletal Elements and Plasma Membrane Organization, (G. Poste and G. Nicholson, eds.), Elsevier/North-Holland, Amsterdam, pp. 1–55.
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© 1986 Plenum Press, New York
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Sachs, F. (1986). Mechanotransducing Ion Channels. In: Latorre, R. (eds) Ionic Channels in Cells and Model Systems. Series of the Centro de Estudios CientÃficos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5077-4_11
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DOI: https://doi.org/10.1007/978-1-4684-5077-4_11
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