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Extracellular Matrix Involvement in Epithelial Branching Morphogenesis

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The Cell Surface in Development and Cancer

Part of the book series: Developmental Biology ((DEBO,volume 3))

Abstract

Branching morphogenesis is a major developmental process used by a large array of embryonic organs. Examples of organs whose development involves branching morphogenesis include submandibular, sublingual, and parotid sali vary glands, mammary glands, lungs, pancreas, and kidneys. In each case, an epithelium undergoes repeated branching activity, in concert with mitotic growth, that results in the formation of an organ-specific pattern of clefts or branch points and the generation of large amounts of epithelial surface area for the available amount of organ space. The advantage would appear to be that epithelial surface area for such functions as secretory activity and gas exchange is maximized, resulting in highly efficient compact organs.

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Authors and Affiliations

  1. Division of Biology, Kansas State University, Manhattan, Kansas, 66506, USA

    Brian S. Spooner, Brad Stokes & Kenneth E. Bassett

  2. Department of Chemistry, University of Montana, Missoula, Montana, 59812, USA

    Holly A. Thompson-Pletscher

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  1. Brian S. Spooner
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  2. Holly A. Thompson-Pletscher
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  3. Brad Stokes
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  4. Kenneth E. Bassett
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Editors and Affiliations

  1. Department of Biology, Princeton University, Princeton, New Jersey, 08544, USA

    Malcolm S. Steinberg

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© 1986 Plenum Press, New York

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Spooner, B.S., Thompson-Pletscher, H.A., Stokes, B., Bassett, K.E. (1986). Extracellular Matrix Involvement in Epithelial Branching Morphogenesis. In: Steinberg, M.S. (eds) The Cell Surface in Development and Cancer. Developmental Biology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5050-7_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5050-7_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5052-1

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