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Production of Human Monoclonal Antibodies

  • Chapter
Monoclonal Antibodies and Functional Cell Lines

Abstract

The need to obtain human monoclonal antibodies has not been overshadowed by the immense success of mouse monoclonal antibody technology. Human monoclonal antibodies will be less antigenic for human in vivo studies and therapy; they will be more likely to recognize antigenic subtleties not easily detected by xenogeneic antibodies, and they will have less rapid catabolism in vivo. The study of human B-cell differentiation and development will be furthered by the availability of human hybridomas. These hybridomas also will be useful to dissect the human humoral immune response in autoimmune disease, cancer, and allergy.

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  1. David W. Buck

    Present address: Becton Dickinson Monoclonal Center, Inc., Mountain View, California, 94043, USA

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  1. Cetus Immune Research Laboratories, Palo Alto, California, 94303, USA

    David W. Buck, James W. Larrick, Andrew Raubitschek, Kenneth E. Truitt, G. Senyk, J. Wang & Bradley J. Dyer

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  1. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Roger H. Kennett

  2. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    Kathleen B. Bechtol

  3. Cytogen Corporation, Princeton, New Jersey, USA

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© 1984 Plenum Press, New York

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Buck, D.W. et al. (1984). Production of Human Monoclonal Antibodies. In: Kennett, R.H., Bechtol, K.B., McKearn, T.J. (eds) Monoclonal Antibodies and Functional Cell Lines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4673-9_11

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  • DOI: https://doi.org/10.1007/978-1-4684-4673-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4675-3

  • Online ISBN: 978-1-4684-4673-9

  • eBook Packages: Springer Book Archive

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