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Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes

  • Chapter
Contemporary Topics in Molecular Immunology

Abstract

During the past few years our understanding of the mechanisms involved in the generation of antibody diversity has greatly increased from studies of monoclonal antibodies (hybridomas) and the use of recombinant DNA technology. While much attention has appropriately been focused on these developments, it is nonetheless surprising how little we actually know about the function of these molecules at the molecular level. Since we assume that the primary role of antibodies is to bind antigens, it is obvious that a detailed analysis of this process is essential to an understanding of the mechanisms by which antibodies carry out their biological functions.

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Authors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Stuart Rudikoff

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  1. Stuart Rudikoff
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Editors and Affiliations

  1. Department of Biochemistry Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

    F. P. Inman

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    T. J. Kindt

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© 1983 Plenum Press, New York

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Rudikoff, S. (1983). Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes. In: Inman, F.P., Kindt, T.J. (eds) Contemporary Topics in Molecular Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4517-6_6

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  • DOI: https://doi.org/10.1007/978-1-4684-4517-6_6

  • Publisher Name: Springer, Boston, MA

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