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Suppressor Cells and Cancer: Inhibition of Immune Functions by Macrophages

  • Chapter
The Reticuloendothelial System

Abstract

The macrophage may be viewed either as a primordial, poorly differentiated cell, or as a sophisticated mastermind of the immune system (Varesio et al., 1980g). On the one hand, the macrophage resembles the primordial amoeba, perceiving a “foreign” disturbance, engulfing and degrading it. On the other hand, by presenting antigens to the responding cells, macrophages can trigger immune responses and, by delivering inhibitory signals, they can modulate the extent of the responses. All of these attributes may be relevant to the tumor-host relationship. Macrophages could, in fact, modulate the specific antitumor response, exert a nonspecific toxic effect on neoplastic cells, and help to eliminate necrotic material. The ability of macrophages to suppress the immune response in tumor-bearing individuals is the topic of the present discussion.

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References

  • Adams, D. O., 1980, J. Immunol. 124:286.

    PubMed  CAS  Google Scholar 

  • Adler, W. H., Takiguchi, T., and Smith, R. T., 1971, Cancer Res. 31:864.

    CAS  Google Scholar 

  • Alexander, P., and Evans, R., 1971, Nature New Biol. 232:76.

    PubMed  CAS  Google Scholar 

  • Allison, A. C, 1978, Immunol. Rev. 40:3.

    PubMed  CAS  Google Scholar 

  • Anaclerio, A., Moras, M. L., Conti, G., Mistrello, G., and Spreafico, F., 1978, J. Nail. Cancer Inst. 61:471.

    CAS  Google Scholar 

  • Baird, L. G., and Kaplan, A. M., 1977a, Cell. Immunol. 28:36.

    PubMed  CAS  Google Scholar 

  • Baird, L. G., and Kaplan, A. M., 1977b, Cell. Immunol. 28:22.

    PubMed  CAS  Google Scholar 

  • Becker, S., and Klein, E., 1976, Eur. J. Immunol. 6:892.

    Google Scholar 

  • Berlinger, N. T., and Good, R. A., 1980, Cancer 45:1112.

    PubMed  CAS  Google Scholar 

  • Berlinger, N. T., Lopez, C., and Good, R. A., 1976, Nature (London) 260:145.

    CAS  Google Scholar 

  • Blomgren, H., Baral, E., Petrini, B., and Wasserman, J., 1976, Clin. Oncol. 2:379.

    PubMed  CAS  Google Scholar 

  • Bloom, B. R., Gaffney, J., and Jimenez, L., 1972, J. Immunol. 109:1395.

    PubMed  CAS  Google Scholar 

  • Bluestone, J. A., and Lopez, C., 1979a, J. Natl. Cancer Inst. 63:1221.

    PubMed  CAS  Google Scholar 

  • Bluestone, J. A., and Lopez, C., 1979a, J. Natl. Cancer Inst. 65:1215.

    Google Scholar 

  • Bonventre, P. F., and Mukkada, A. J., 1974, Infect. Immun. 10:1391.

    PubMed  CAS  Google Scholar 

  • Broder, S., Humphrey, R., Durn, M., Blackman, M., Meade, B., Goldman, B., Strober, W., and Waldmann, T., 1975, N. Engl. J. Med. 293:887.

    PubMed  CAS  Google Scholar 

  • Brunda, M. J., Herberman, R. B., and Holden, H. T., 1980, J. Immunol. 12:2682.

    Google Scholar 

  • Brunda, M. J., Taramelli, D., Holden, H. T., and Varesio, L., 1982, in: NK Cells and other Natural Effector Cells (R. B. Herberman, ed.), pp. 535–540, Academic Press, New York.

    Google Scholar 

  • Campbell, M. W., Sholley, M. M., and Miller, G. A., 1980, Cell. Immunol. 50:153.

    PubMed  CAS  Google Scholar 

  • Cantor, H., and Jandinski, J., 1975, J. Exp. Med. 140:1712.

    Google Scholar 

  • Civin, C. C., Dorfman, N., Eggers, A., Fink, K., Penvose, D., Hsu, C. K., and Wunderlich, J. R., 1979, J. Immunol. 23:2550.

    Google Scholar 

  • Cohen, S., and Yoshida, T., 1977, J. Immunol. 119:719.

    PubMed  CAS  Google Scholar 

  • Cohn, Z. A., and Benson, B., 1965, J. Exp. Med. 121:153.

    PubMed  CAS  Google Scholar 

  • Cone, L., and Uhr, J. W., 1964, J. Clin. Invest. 43:2241.

    PubMed  CAS  Google Scholar 

  • Cudkowicz, G., and Hochman, P. S., 1979, Immunol. Rev. 44:13.

    PubMed  CAS  Google Scholar 

  • David, J. R., and Remold, H. G., 1979, in: Biology of Lymphokines (S. Cohen, E. Pick, and J. J. Oppenheim, eds.), pp. 121–140, Academic Press, New York.

    Google Scholar 

  • Dean, J. H., Cannon, G. B., Jerrels, T. R., McCoy, J. L., and Herberman, R. B., 1980, in: Neoplasm Immunity: Experimental and Clinical (R. Crispen, ed.), pp. 357–386, ElsevierJNorth-Holland, Amsterdam.

    Google Scholar 

  • Djeu, J. Y., Stocks, N., Varesio, L., Holden, H. T., and Herberman, R. B., 1981, Cell. Immunol. 58:49.

    PubMed  CAS  Google Scholar 

  • Edelson, P. J., and Cohn, Z. A., 1975, J. Exp. Med. 144:1581.

    Google Scholar 

  • Edelson, P. J., and Erbs, C., 1978, J. Exp. Med. 147:77.

    PubMed  CAS  Google Scholar 

  • Eggers, A. E., and Wunderlich, J. R., 1975, J. Immunol. 114:1554.

    PubMed  CAS  Google Scholar 

  • Ehrlich, R., Efrati, M., and Bar-Eyal, A., 1980a, Int. J. Cancer 26:315.

    PubMed  CAS  Google Scholar 

  • Ehrlich, R., Efrati, M., and Witz, I. P., 1980b, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), pp. 997–1009, Academic Press, New York.

    Google Scholar 

  • Elgert, K. D., and Farrar, W. L., 1978a, J. Immunol. 120:1345.

    PubMed  CAS  Google Scholar 

  • Elgert, K. D., and Farrar, W. L., 1978b, Cell. Immunol. 40:356.

    PubMed  CAS  Google Scholar 

  • Elgert, K. D., and Farrar, W. L., 1978c, Cell. Immunol. 40:365.

    PubMed  Google Scholar 

  • Epstein, L. B., 1977, in: Interferons and Their Actions (W. E. Stewart, ed.), pp. 81–95, CRC Press, Cleveland.

    Google Scholar 

  • Evans, R., 1972, Transplantation 14:468.

    PubMed  CAS  Google Scholar 

  • Fahey, J. L., and Humphrey, J. H., 1962, Immunology 5:110.

    PubMed  CAS  Google Scholar 

  • Fahey, J. L., Scoggins, R., Utz, J. P., and Szwed, C. F., 1963, Am. J. Med. 35:698.

    PubMed  CAS  Google Scholar 

  • Farr, A. G., Wechter, W. J., Kiely, J. M., and Unanue, E. R., 1979, J. Immunol. 122:2405.

    PubMed  CAS  Google Scholar 

  • Fernbach, B. R., Kirchner, H., Bonnard, G. P., and Herberman, R. B., 1976a, Transplantation 21:381.

    PubMed  CAS  Google Scholar 

  • Fernbach, B. R., Kirchner, H., Bonnard, G. P., and Herberman, R. B., 1976b, Cell Immunol. 22:399.

    PubMed  CAS  Google Scholar 

  • Fidler, I. J., 1975, J. Natl. Cancer Inst. 55:1159.

    PubMed  CAS  Google Scholar 

  • Fisher, B. R., Gregario, R. M., and Fisher, B., 1975, Cancer 36:1.

    PubMed  CAS  Google Scholar 

  • Fishman, M., 1980, Cell. Immunol. 55:174.

    PubMed  CAS  Google Scholar 

  • Folch, H., and Waksman, B. H., 1973, Cell. Immunol. 9:12.

    PubMed  CAS  Google Scholar 

  • Folch, H., and Waksman, B. H., 1974, J. Immunol. 113:127.

    PubMed  CAS  Google Scholar 

  • Forbes, J. T., Greco, F. A., and Oldham, R. K., 1980, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), pp. 1031–1047, Academic Press, New York.

    Google Scholar 

  • Forni, G., Giovarelli, M., Varesio, L., and Landolfo, S., 1979a, in: Current Trends in Cancer Immunology (R. B. Herberman, S. Ferrone, and R. A. Reisfeld, eds.), pp. 73–84, Garland STPM, New York.

    Google Scholar 

  • Forni, G., Varesio, L., Giovarelli, M., and Cavallo, G., 1979b, in: Tumor Associated Antigens and Their Specific Immune Response (F. Spreafico and R. Arnon, eds.), pp. 167–191, Academic Press, New York.

    Google Scholar 

  • Forni, G., Varesio, L., Giovarelli, M., and Landolfo, S., 1979c, Transplantation 27:433.

    PubMed  CAS  Google Scholar 

  • Forni, G., Giovarelli, M., Lanfrancone, L., and Varesio, L., 1982, Int. J. Cancer 29:695.

    PubMed  CAS  Google Scholar 

  • Garrigues, H. J., Romeo, P., Hellström, I., and Hellström, K. E., 1981, Cell Immunol. 60:109.

    PubMed  CAS  Google Scholar 

  • Gemsa, D., Seitz, M., Kramer, W., Till, G., and Resch, K., 1978, J. Immunol. 120:1187.

    PubMed  CAS  Google Scholar 

  • Gerson, J. M., 1980, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), pp. 1047–1062, Academic Press, New York.

    Google Scholar 

  • Gerson, J. M., Holden, H. T., Bonnard, G. D., and Herberman, R. B., 1979, Proc. Am. Assoc. Cancer Res. 20:238.

    Google Scholar 

  • Gerson, J. M., Varesio, L., and Herberman, R. B., 1981, Int. J. Cancer 27:263.

    Google Scholar 

  • Gery, L, and Davies, P., 1979, in: Biology of the Lymphokines (S. Cohen, E. Pick, and J. J. Oppenheim, eds.), pp. 347–367, Academic Press, New York.

    Google Scholar 

  • Gillespie, G, Y., and Russell, S. W., 1978, Int. J. Cancer 21:94.

    PubMed  CAS  Google Scholar 

  • Gillespie, G. Y., and Russell, S. W., 1980, J. Reticuloendothelial Soc. 27:535.

    CAS  Google Scholar 

  • Gillespie, G. Y., Hansen, C. B., and Russell, S. W., 1978, Br. J. Cancer 38:365.

    PubMed  CAS  Google Scholar 

  • Gillette, R. W., and Boone, C. W., 1973, J. Natl. Cancer Inst. 50:1391.

    PubMed  CAS  Google Scholar 

  • Gillette, R. W., and Boone, C. W., 1975, Cancer Res. 35:3774.

    PubMed  CAS  Google Scholar 

  • Glaser, M., Kirchner, H., Holden, H. T., and Herberman, R. B., 1976, J. Natl. Cancer Inst. 56:865.

    PubMed  CAS  Google Scholar 

  • Goodwm, J. S., Messner, R. P., Bankhurst, A. D., Peake, G. T., Saiki, J. H., and Williams, R. C, Jr., 1977, N. Engl. J. Med. 297:963.

    Google Scholar 

  • Gorcyznski, R. M., 1974, J. Immunol. 112:1826.

    Google Scholar 

  • Gordon, S., Unkeless, J. C., and Cohn, Z. A., 1974, J. Exp. Med. 140:995.

    PubMed  CAS  Google Scholar 

  • Gorelik, E., and Herberman, R. B., 1981, J. Natl. Cancer Inst. 67:1317.

    PubMed  CAS  Google Scholar 

  • Hanna, N., and Kripke, M. L., 1979, Cell. Immunol. 43:293.

    PubMed  CAS  Google Scholar 

  • Hanna, N., Blanc, S., and Nelkin, D., 1980, Cell. Immunol. 53:222.

    Google Scholar 

  • Havas, H. F., and Schiffman, G., 1976, Fed. Proc. 32:250.

    Google Scholar 

  • Heller, P., Bhoopalam, N., Cabana, V., Costea, N., and Yakulis, V., 1973, Ann. N.Y. Acad. Sci. 207:468.

    PubMed  CAS  Google Scholar 

  • Hellström, L, and Hellström, K. E., 1979, Transplant. Proc. 11:1076.

    Google Scholar 

  • Herberman, R. B., 1974, Adv. Cancer Res. 19:207.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., 1977, Am. J. Clin. Pathol. 68:688.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B. (ed.), 1980, Natural Cell-Mediated Immunity Against Tumors, Academic Press, New York.

    Google Scholar 

  • Herberman, R. B., Nunn, M. E., and Lavrin, D. H., 1975, Int. J. Cancer 16:216.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., Djeu, J. Y., Kay, H. D., Ortaldo, J. R., Riccardi, C., Bonnard, G. D., Holden, H. T., Fagnani, R., Santoni, A., and Puccetti, P., 1979a, Immunol. Rev. 44:43.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., Varesio, L., Tagliabue, A., Maca, R., Holden, H. T., White, S., Bonnard, G. D., Jerrells, T., and Dean, J. H., 1979b, in: Immunobiology and Immunotherapy of Cancer (W. D. Terry and Y. Yamamura, eds.), pp. 191–203, ElsevierJNorth-Holland, Amsterdam.

    Google Scholar 

  • Herberman, R. B., Holden, H. T., Varesio, L., Taniyama, T., Puccetti, P., Kirchner, H., Gerson, J., Bonnard, G., and Haskill, J. S., 1980a, in: In-situ Expression of Tumor Immunity (I. Witz and M. Hanna, eds.), pp. 61–67, Plenum Press, New York.

    Google Scholar 

  • Herberman, R. B., Holden, H. T., Djeu, J. Y., Jerrells, T. R., Varesio, L., Tagliabue, A., White, S. L., Oehler, J. R., and Dean, J. H., 1980b, in: Macrophages and Lymphocytes, Part B (M. R. Escobar and H. Friedman, eds.), pp. 361–379, Plenum Press, New York.

    Google Scholar 

  • Herberman, R. B., Brunda, M. J., Domzig, W., Fagnani, R., Goldfarb, R. H., Holden, H. T., Ortaldo, J. R., Reynolds, C. W., Riccardi, C., Santoni, A., Stadler, B. M., Taramelli, D., Timonen, T., and Varesio, L., 1982, in: The Biological Significance of Immune Regulation (M. E. Gershwin and L. N. Ruben, eds.), pp. 139–166, Dekker, New York.

    Google Scholar 

  • Herr, H. W., 1977, Surg. Forum 28:546.

    PubMed  CAS  Google Scholar 

  • Herscowitz, H. B., Conrad, R. E., and Pennline, K. J., 1979, Adv. Exp. Med. Biol. 121:459.

    PubMed  CAS  Google Scholar 

  • Herscowitz, H. B., Holden, H. T., Bellanti, J. A., and Ghaffar, A., 1981, Manual of Macrophage Methodology, Dekker, New York.

    Google Scholar 

  • Hibbs, J. B., Jr., 1974, Science 184:468.

    PubMed  CAS  Google Scholar 

  • Hillinger, S.M., and Herzig, G. P., 1978, J. Clin. Invest. 50:1620.

    Google Scholar 

  • Holden, H. T., and Herberman, R. B., 1981, in: Mechanisms of Immunity to Virus-Induced Tumors (J. B. Blasecki, ed.), Dekker, New York.

    Google Scholar 

  • Holden, H. T., Haskill, J. S., Kirchner, H., and Herberman, R. B., 1976, J. Immunol. 117:440.

    PubMed  CAS  Google Scholar 

  • Holden, H. T., Varesio, L., Taniyama, T., and Puccetti, P., 1980, in: Macrophages and Lymphocytes, Part B (M. R. Escobar and H. Friedman, eds.), pp. 509–520, Plenum Press, New York.

    Google Scholar 

  • Holden, H. T., Djeu, J. Y., Brunda, M. J., and Herberman, R. B., 1980a, in: Biochemical Characterization of Lymphokines (A. L. de Weck, F. Kristensen, and M. Landy, eds.), pp. 369–373, Academic Press, New York.

    Google Scholar 

  • Hopper, K. E., and Nelson, D. S., 1979, Cell. Immunol. 47:163.

    PubMed  CAS  Google Scholar 

  • Humes, J. L., Burger, S., Galavage, M., Kuehl, F. A., Wightman, P. D., Dahlgren, M. E., Davies, P.,and Bonney, R. J., 1980, J. Immunol. 124:2110.

    PubMed  CAS  Google Scholar 

  • Jerrells, T. R., Dean, J. H., Richardson, G. L., McCoy, J. L., and Herberman, R. B., 1978, J. Natl. Cancer Inst. 61:1001.

    PubMed  CAS  Google Scholar 

  • Jett, J. R., Mantovani, A., and Herberman, R. B., 1980, Cell. Immunol. 54:425.

    PubMed  CAS  Google Scholar 

  • Johnson, H. M., and Baron, S., 1977, Pharmacol. Ther. 1:349.

    CAS  Google Scholar 

  • Johnson, H. M., Stanton, G. J., and Baron, S., 1977, Proc. Soc. Exp. Biol Med. 154:138.

    PubMed  CAS  Google Scholar 

  • Kaplan, A. M., and Mohanakumar, T., 1977, J. Exp. Med. 146:1461.

    PubMed  CAS  Google Scholar 

  • Katzmann, J. A., 1978, J. Immunol 121:1405.

    PubMed  CAS  Google Scholar 

  • Keller, R., 1976, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), pp. 10–35, Academic Press, New York.

    Google Scholar 

  • Kennard, J., and Zolla-Pazner, S., 1980, J. Immunol. 124:268.

    PubMed  CAS  Google Scholar 

  • Kerbel, R. S., Pross, H. R., and Elliott, E. V., 1975, Int. J. Cancer 15:918.

    PubMed  CAS  Google Scholar 

  • Kirchner, H., 1978, Eur. J. Cancer 14:453.

    PubMed  CAS  Google Scholar 

  • Kirchner, H., Herberman, R. B., Glaser, M., and Lavrin, D. H., 1974a, Cell. Immunol. 13:32.

    PubMed  CAS  Google Scholar 

  • Kirchner, H., Chused, T. M., Herberman, R. B., Holden, H. T., and Lavrin, D. H., 1974b, J. Exp. Med. 139:1473.

    PubMed  CAS  Google Scholar 

  • Kirchner, H., Muchmore, A. W., Chused, T. M., Holden, H. T., and Herberman, R. B., 1975a, J. Immunol. 114:206.

    PubMed  CAS  Google Scholar 

  • Kirchner, H., Glaser, M., and Herberman, R. B., 1975b, Nature (London) 251:369.

    Google Scholar 

  • Klimpel, G. R., 1979, Cell. Immunol. 47:218.

    PubMed  CAS  Google Scholar 

  • Klimpel, G. R., and Henney, C. S., 1978, J. Immunol. 120:563.

    PubMed  CAS  Google Scholar 

  • Knapp, W., and Baumgartner, G., 1978, J. Immunol. 121:1177.

    PubMed  CAS  Google Scholar 

  • Kolb, J. P., Arrian, S., and Zolla-Pazner, S., 1977, J. Immunol 118:702.

    PubMed  CAS  Google Scholar 

  • Krakauer, R. S., Strober, W. S., and Waldman, T., 1976, Clin. Res. 24:377.

    Google Scholar 

  • Krakauer, R. S., Strober, W., and Waldman, T. A., 1977, J. Immunol. 118:1385.

    PubMed  CAS  Google Scholar 

  • Kruisbeek, A. M., Zijlstra, J., and Zurcher, C., 1978, Eur. J. Immunol. 8:200.

    PubMed  CAS  Google Scholar 

  • Kung, J. T., Brooks, S. B., Jakway, J., Leonard, L. L., and Talmage, D. W., 1977, J. Exp. Med. 146:665.

    PubMed  CAS  Google Scholar 

  • Landolfo, S., Herberman, R. B., and Holden, H. T., 1977, J. Natl. Cancer Inst. 59:1675.

    PubMed  CAS  Google Scholar 

  • Landolfo, S., Giovarelli, M., Martinotti, G., Varesio, L., and Cappuccinelli, P., 1979, Eur. J. Cancer 15:27.

    PubMed  CAS  Google Scholar 

  • Lause, D. B., 1979, J. Reticuloendothelial Soc. 26:775.

    CAS  Google Scholar 

  • Lazdins, J. K., Kuhner, A. L., David, J. R., and Karnovsky, M. L., 1978, J. Exp. Med. 148:746.

    PubMed  CAS  Google Scholar 

  • Lee, K. C., and Wong, M., 1980, J. Immunol 125:86.

    PubMed  CAS  Google Scholar 

  • Lee, L. F., Sharma, J. M., Nazerian, K., and Witter, R. L., 1978, J. Immunol 120:1554.

    PubMed  CAS  Google Scholar 

  • Mattingly, J. A., and Kemp, J. D., 1979, Cell Immunol. 148:195.

    Google Scholar 

  • Mattingly, J. A., Eardley, D. D., Kemp, J. D., and Gershon, R. K., 1979, J. Immunol. 122:787.

    PubMed  CAS  Google Scholar 

  • Mehra, V., Mason, L. H., Fields, J. P., and Bloom, B. R., 1979, J. Immunol. 123:1813.

    PubMed  CAS  Google Scholar 

  • Metzger, Z. V., Hoffeld, J. T., and Oppenheim, J., 1980, J. Immunol 124:983.

    PubMed  CAS  Google Scholar 

  • Naor, D., 1979, Adv. Cancer Res. 29:45.

    PubMed  CAS  Google Scholar 

  • Nathan, C. F., Karnovsky, M. L., and David, J. R., 1971, J. Exp. Med. 133:1356.

    PubMed  CAS  Google Scholar 

  • Nathan, C. F., Silverstein, S. C., Brukner, L. H., and Cohn, Z. A., 1979, J. Exp. Med. 149:100.

    PubMed  CAS  Google Scholar 

  • Nedrud, J., Toutin, M., and Clark, W. R., 1975, J. Exp. Med. 142:960.

    PubMed  CAS  Google Scholar 

  • Nelson, M., and Nelson, P. S., 1978, J. Immunol. 34:277.

    CAS  Google Scholar 

  • Oehler, J. R., Herberman, R. B., Campbell, D. A., and Djeu, J. Y., 1977a, Cell Immunol 29:238.

    PubMed  CAS  Google Scholar 

  • Oehler, J. R., Campbell, D. A., and Herberman, R. B., 1977b, Cell Immunol 28:355.

    PubMed  CAS  Google Scholar 

  • Oehler, J. R., Herberman, R. B., and Holden, H. T., 1978, Pharmacol. Ther. 2:551.

    Google Scholar 

  • Orange, R. P., Moore, E. G., and Gelfand, E. W,, 1980, J. Immunol 124:2264.

    PubMed  CAS  Google Scholar 

  • Pan Yung, Y., and Cudkowicz, G., 1978, J. Immunol 121:1990.

    Google Scholar 

  • Parkhouse, R. M., and Dutton, R. W., 1966, J. Immunol. 97:663.

    PubMed  CAS  Google Scholar 

  • Peavy, D. L., and Pierce, C. W., 1975, J. Immunol. 115:1521.

    PubMed  CAS  Google Scholar 

  • Pennline, K. J., Conrad, R. E., Gerber, H. R., and Herscowitz, H. B., 1979, J. Reticuloendothelial Soc. 25:495.

    CAS  Google Scholar 

  • Perkins, E., and Makivodan, T., 1965, J. Immunol. 94:765.

    PubMed  CAS  Google Scholar 

  • Pick, E., Cohen, S., and Openheim, J. J., 1979, in: Biology of the Lymphokines (S. Cohen, E. Pick, and J. J. Oppenheim, eds.), pp. 1–12, Academic Press, New York.

    Google Scholar 

  • Plata, F., MacDonald, R. H., and Shain, B., 1979, J. Immunol. 123:852.

    PubMed  CAS  Google Scholar 

  • Pope, B. L., Whitney, R. B., Levy, J. G., and Kilburn, D. G., 1976, J. Immunol 116:1342.

    PubMed  CAS  Google Scholar 

  • Pope, B. L., Whitney, R. B., and Levy, J. G., 1978, J. Immunol 120:2033.

    PubMed  CAS  Google Scholar 

  • Pross, H. F., and Baines, M. G., 1976, Int. J. Cancer 18:593.

    PubMed  CAS  Google Scholar 

  • Pross, H. F., and Baines, M. G., 1980, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York.

    Google Scholar 

  • Puccetti, P., and Holden, H. T., 1979, Int. J. Cancer 23:123.

    PubMed  CAS  Google Scholar 

  • Quan, P. C., and Burtin, P., 1978, Cancer Res. 38:288.

    PubMed  CAS  Google Scholar 

  • Raff, H. V., and Hinricks, D. J., 1977a, Cell Immunol 29:96.

    PubMed  CAS  Google Scholar 

  • Raff, H. V., and Hinricks, D. J., 1977b, Cell Immunol 29:109.

    PubMed  CAS  Google Scholar 

  • Raff, H. V., and Hinricks, D. J., 1977c, Cell Immunol 29:118.

    PubMed  CAS  Google Scholar 

  • Riccardi, C., Santoni, A., Barlozzari, T., Cesarin, C., and Herberman, R. B., 1981, Int. J. Cancer 28:811.

    PubMed  CAS  Google Scholar 

  • Rich, R. R., and Pierce, C. W., 1974, J. Immunol. 112:1360.

    PubMed  CAS  Google Scholar 

  • Riglar, C., and Cheers, C., 1980, Cell. Immunol. 49:154.

    PubMed  CAS  Google Scholar 

  • Ruco, L. P., and Meltzer, M. S., 1978a, J. Immunol 120:1054.

    PubMed  CAS  Google Scholar 

  • Ruco, L. P., and Meltzer, M. S., 1978b, J. Immunol. 121:2035.

    PubMed  CAS  Google Scholar 

  • Russell, S. W., and Cochrane, C. G., 1974, Int. J. Cancer 13:54.

    PubMed  CAS  Google Scholar 

  • Russell, S. W., Doe, W. F., and Cochrane, C. G., 1976, J. Immunol. 116:164.

    Google Scholar 

  • Russell, S. W., Doe, W. F., and Mclntosh, A. T., 1977, J. Exp. Med. 146:1511.

    PubMed  CAS  Google Scholar 

  • Santoni, A., Herberman, R. B., and Holden, H. T., 1979, J. Natl. Cancer Inst. 62:109.

    PubMed  CAS  Google Scholar 

  • Santoni, A., Riccardi, C., Sorci, V., and Herberman, R. B., 1980a, J. Immunol 124:2339.

    Google Scholar 

  • Santoni, A., Riccardi, C., Barlozzari, T., and Herberman, R. B., 1980b, Int. J. Cancer 26:837.

    PubMed  CAS  Google Scholar 

  • Schechter, G. p., and Soehnlen, F., 1978, Blood 52:261.

    PubMed  CAS  Google Scholar 

  • Schultz, R. M., Papamatheakis, J. D., and Chirigos, M. A., 1977, Science 197:674.

    PubMed  CAS  Google Scholar 

  • Scott, W. A., Zrike, J. M., Hamill, A. L., Kempe, J., and Cohn, Z. A., 1980, J. Exp. Med. 152:324.

    PubMed  CAS  Google Scholar 

  • Sibbit, W. L., Bankhurst, A. D., and Williams, R. C., 1978, J. Clin. Invest. 61:55.

    Google Scholar 

  • Smith, F. M., Grenon, M., and Owens, J., 1960, J. Natl. Cancer Inst. 25:803.

    Google Scholar 

  • Snyderman, R., Pike, M. C., Blaylock, B. L., and Weinstein, P., 1976, J. Immunol. 116:585.

    PubMed  CAS  Google Scholar 

  • Stewart, C. C., and Beetham, K. L., 1978, Int. J. Cancer 22:152.

    PubMed  CAS  Google Scholar 

  • Stuart, A. E., 1977, in: The Macrophage and Cancer (K. James, B. McBride, and A. Stuart, eds.), pp. 1–4, Econoprint, Edinburgh.

    Google Scholar 

  • Stubbs, M., Kuhner, A. V., Glass, E. A., David, J. R., and Karnovsky, M. L., 1973, J. Exp. Med. 137:537.

    PubMed  CAS  Google Scholar 

  • Tadakuma, T., and Pierce, C. W., 1976, J. Immunol 117:967.

    PubMed  CAS  Google Scholar 

  • Tanapatchaiyapong, P., and Zolla, S., 1974, Science 186:748.

    PubMed  CAS  Google Scholar 

  • Taniyama, T., and Holden, H. T., 1979a, Int. J. Cancer 24:151.

    PubMed  CAS  Google Scholar 

  • Taniyama, T., and Holden, H. T., 1979b, Cell Immunol. 48:369.

    PubMed  CAS  Google Scholar 

  • Taramelli, D., and Varesio, L., 1981, J. Immunol. 127:58.

    PubMed  CAS  Google Scholar 

  • Taramelli, D., Holden, H. T., and Varesio, L., 1980, J. Immunol. Methods 37:225.

    PubMed  CAS  Google Scholar 

  • Taramelli, D., Holden, H. T., and Varesio, L., 1981, J. Immunol. 126:2123.

    PubMed  CAS  Google Scholar 

  • Ting, C. C., and Rodriguez, D., 1979, J. Immunol. 123:801.

    PubMed  CAS  Google Scholar 

  • Ting, C. C., and Rodrigues, D., 1980a, Int. J. Cancer 25:243.

    PubMed  CAS  Google Scholar 

  • Ting, C. C., and Rodrigues, D., 1980b, J. Immunol 124:1039.

    PubMed  CAS  Google Scholar 

  • Underwood, J. C, 1974, Br. J. Cancer 30:538.

    PubMed  CAS  Google Scholar 

  • Vánky, F., Klein, E., Stjernsward, J., Rodrigues, L., Peterffy, A., Steiner, L., and Nilsonne, U., 1978, Int. J. Cancer 22:679.

    PubMed  Google Scholar 

  • Van Loveren, H., and Den Otter, W., 1974, J. Natl. Cancer Inst. 53:1057.

    PubMed  Google Scholar 

  • Varesio, L., and Eva, A., 1980, J. Immunol. Methods 33:231.

    PubMed  CAS  Google Scholar 

  • Varesio, L., and Holden, H. T., 1980a, J. Immunol. 125:1694.

    PubMed  CAS  Google Scholar 

  • Varesio, L., and Holden, H. T., 1980b, J. Immunol. 124:2288.

    PubMed  CAS  Google Scholar 

  • Varesio, L., and Holden, H. T., 1980c, Cell. Immunol 56:16.

    PubMed  CAS  Google Scholar 

  • Varesio, L., Giovarelli, M., Landolfo, S., and Forni, G., 1979a, Cancer Res. 39:4983.

    PubMed  CAS  Google Scholar 

  • Varesio, L., Herberman, R. B., Gerson, J. M., and Holden, H. T., 1979b, Int. J. Cancer 24:97.

    PubMed  CAS  Google Scholar 

  • Varesio, L., Eva, A., Cavallo, G., and Herberman, R. B., 1980a, Boll. Ist. Sieroter. Milan 59:12.

    PubMed  CAS  Google Scholar 

  • Varesio, L., Holden, H. T., and Taramelli, D., 1980f, J. Immunol 125:2810.

    PubMed  CAS  Google Scholar 

  • Varesio, L., Landolfo, S., and Forni, G., 1980c, Dev. Comp. Immunol 4:11.

    PubMed  CAS  Google Scholar 

  • Varesio, L., Eva, A., and Holden, H. T., 1981a, in: Manual of Macrophage Methodology: Collection, Characterization and Function (H. B. Herscowitz, H. T. Holden, J. A. Bellanti, and A. Ghaffar, eds.), pp. 369–375, Dekker, New York.

    Google Scholar 

  • Varesio, L., Holden, H. T., and Taramelli, D., 1981b, Cell Immunol 63:279.

    PubMed  CAS  Google Scholar 

  • Vassali, J. D., and Reich, E., 1977, J. Exp. Med. 145:429.

    Google Scholar 

  • Veit, B. C., and Feldman, J. D., 1975, Int. J. Cancer 15:367.

    PubMed  CAS  Google Scholar 

  • Veit, B. C., and Feldman, J. D., 1976a, J. Immunol 117:655.

    PubMed  CAS  Google Scholar 

  • Veit, B. C., and Feldman, J. D., 1976b, J. Immunol. 117:646.

    PubMed  CAS  Google Scholar 

  • Wachsmuth, E. D., 1975, Exp. Cell Res. 96:409.

    PubMed  CAS  Google Scholar 

  • Wahl, S. M., Wahl, L. M., McCarthy, J. B., Chedid, L., and Mergenhagen, S. E., 1979, J. Immunol. 122:2226.

    PubMed  CAS  Google Scholar 

  • Waksman, B. H., 1981, in: The Lymphokines (J. W. Hadden and W. E. Stewart, eds.), pp. 1–28, The Humana Press, N.J.

    Google Scholar 

  • Waldman, T. A., Broder, S., and Krakauer, R., 1976, Fed. Proc. 35:2067.

    Google Scholar 

  • Webb, P. J., and Brooks, G. G., 1980, Cell Immunol. 52:370.

    PubMed  CAS  Google Scholar 

  • Webb, P. J., Brooks, C. G., and Baldwin, R. W., 1980, Cell. Immunol. 52:381.

    PubMed  CAS  Google Scholar 

  • Weiland, E., and Mussgay, M., 1977, Eur. J. Cancer 13:705.

    PubMed  CAS  Google Scholar 

  • Weinberg, J. B., Chapman, H. A., Jr., and Hibbs, J. B., Jr., 1978, J. Immunol. 121:72.

    PubMed  CAS  Google Scholar 

  • Weiss, A., and Fitch, F. W., 1977, J. Immunol. 119:510.

    PubMed  CAS  Google Scholar 

  • Weiss, A., and Fitch, F. W., 1978, J. Immunol. 120:357.

    PubMed  CAS  Google Scholar 

  • Werb, Z., and Gordon, S., 1975a, J. Exp. Med. 142:346.

    PubMed  CAS  Google Scholar 

  • Werb, Z., and Gordon, S., 1975b, J. Exp. Med. 142:361.

    PubMed  CAS  Google Scholar 

  • Whitney, R. B., Kelly, B. S., and Levy, J. G., 1977, Eur. J. Cancer 14:699.

    Google Scholar 

  • Wing, E. J., and Remington, J. S., 1977, Cell. Immunol. 30:108.

    PubMed  CAS  Google Scholar 

  • Wood, G. W., and Gollahon, K. A., 1977, J. Natl Cancer Inst. 59:1081.

    PubMed  CAS  Google Scholar 

  • Wood, G. W., and Gollahon, K. A., 1978, Cancer Res. 38:1857.

    PubMed  CAS  Google Scholar 

  • Yamashita, U., and Shevach, E. M., 1977, J. Immunol. 119:1584.

    PubMed  CAS  Google Scholar 

  • Zarling, J. M., Berman, C., and Raich, P. C., 1980, Cancer Immunol. Immunother. 7:243.

    Google Scholar 

  • Zembala, M., Mytar, B., Popiela, T., and Asherson, G. L., 1977, Int. J. Cancer 19:605.

    PubMed  CAS  Google Scholar 

  • Zolla, S., 1972, J. Immunol. 108:1039.

    PubMed  CAS  Google Scholar 

  • Zolla, S., Naor, D., and Tanapatchaiyapong, P., 1974, J. Immunol. 112:2068.

    PubMed  CAS  Google Scholar 

  • Zolla-Pazner, S., Sullivan, B., and Richardson, D., 1976, J. Immunol. 117:563.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Biological Therapeutics Branch, Biological Response Modifiers Program, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Luigi Varesio

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  1. Luigi Varesio
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Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. Medical College of Virginia, Richmond, Virginia, USA

    Mario Escobar

  3. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  4. National Cancer Institute, National Institutes of Health, Fredrick, Maryland, USA

    Ronald B. Herberman

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© 1983 Plenum Press, New York

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Varesio, L. (1983). Suppressor Cells and Cancer: Inhibition of Immune Functions by Macrophages. In: Friedman, H., Escobar, M., Reichard, S.M., Herberman, R.B. (eds) The Reticuloendothelial System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4508-4_7

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  • DOI: https://doi.org/10.1007/978-1-4684-4508-4_7

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