Abstract
A substantial body of evidence implicates prostaglandins as potent, local regulators of the immune response (1). It is well documented, for example, that prostaglandins, especially of the E-series, inhibit lectin or antigen-induced lymphocyte proliferation in vitro (2–5). Recently, it has become evident that T-cell proliferation is dependent on the production and utilization of a soluble protein known as T-cell growth factor (TCGF) or Interleukin-2 (IL-2) (6–8). Current evidence suggests that IL-2 is produced by one subset of T-lymphocytes (producer cells) and that it acts upon another subset of T-lymphocytes (responder cells via specific IL-2 receptors (9,10). The precise sequence of events which regulate the production of IL-2 and the development of specific receptors are not completely understood.
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© 1983 Plenum Press, New York
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Rappaport, R.S., Dodge, G.R. (1983). Effect of Prostaglandins on the Production of Interleukin-2. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_8
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DOI: https://doi.org/10.1007/978-1-4684-4481-0_8
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