Abstract
Results of clinical and experimental animal studies have shown that unusually high levels of catecholamines in the blood cause a variety of morphological and functional changes in the heart (1, 18, 22, 25, 28). The endogenous stores of adenine triphosphate and creatine phosphate are depleted (8, 25, 26) and mitochondrial structure-function is impaired (7, 15). Intracellular increase in calcium has been considered to be a determinant factor in this as well as in variety of other models of heart cell damage (8, 21). In this regard catecholamine-induced cardiomyopathy, has been shown to be accompanied by a significant increase in the myocardial calcium content (8,15) indicating changes in the membrane permeability. Strong evidence for the alterations in the permeability of sarcolemma due to isoproterenol treatment was provided by the intracellular diffusion of horseradish peroxidase, an extracellular protein tracer, following the drug injection (19).
Research Scholar of the Canadian Heart Foundation. This work was supported by Grants from the Manitoba Heart Foundation and the Great West Life Assurance Company.
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References
AVIADO, D.M., WNUCK, A.L. & DE BEER, E.J. Cardiovascular effects of sympathomimetic bronchodilators: epinephrine, ephedrine, pseudoephedrine, isoproterenol, methoxyphenamine and isoprophenamine. J. Pharmacol. Exp. Therap. 122, 406–417 (1958).
BARBER, A.A. & BERNHEIM, F. Lipid peroxidation: its measurement, occurrence and significance in animal tissue. Adv. Gerontal. Res. 2, 355–403 (1967).
BEAMISH, R.E., DHILLON, K.S., SINGAL, P.K. & DHALLA, N.S. Protective effect of sulfinpyrazone against catecholamine metabolite adrenochrome-induced arrhythmias. Am. Heart. J. 102, 149–152 (1981).
CHANCE, B., SEISS, H. & BOVERIS, A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59, 527–605 (1979).
COHEN, G. & HEIKKILA, R.E. The generation of hydrogen peroxide, superoxide radical and hydroxyl radical by 6-hydroxy-dopamine, dialuric acid and related cytotoxic agents. J. Biol. Chem. 249, 2447–2452 (1974).
DHALLA, N.S., YATES, J.C., LEE, S.L. & SINGH, A. Functional and subcellular changes in the isolated rat heart perfused with oxidized isoproterenol. J. Mol. Cell. Cardiol. 10, 31–41 (1978).
DHALLA, N.S., SINGAL, P.K. & DHILLON, K. Mitochondrial functions and drug-induced heart disease. In: Drug-Induced Heart Disease, Vol. 5 (Bristow, M.R., ed.) North-Holland Biomedical Press, New York, 39–61 (1980).
FLECKENSTEIN, A., JANKE, T., DOERING, H.J. & PACHINGOER, O. Ca overload as the determinant factor in the production of catecholamine-induced myocardial lesions. Recent Advances in Studies on Cardiac Structure and Metabolism. 2, 455–466 (1973).
GRAHAM, D.G., TIFFANY, S.M., BELL, W.R. & GUTKNECTH, W.F. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds toward C 1300 neuroblastoma cells in vitro. Mol. Pharmacol. 14, 644–653 (1978).
HUNTER, F.E., GEBICKI, J.M., HOFFSTEN, P.E., WEINSTEIN, J. & SCOTT, A. Swelling and lysis of rat liver mitochondria induced by ferrous ions. J. Biol. Chem. 238, 828–835 (1963).
JEQUIER, E. & PERRET, C. Urinary excretions of catecholamines and their main metabolites after myocardial infarction relationship to the clinical syndrome. Eur. J. Clin. Invest. 1, 77–82 (1970).
LEVI, L. Neuroendocrinology of anxiety. In: Studies of Anxiety (Lader, M.H., ed.) Headley, London, P. 40 (1970).
MAY, H.E. & McCay, P.B. Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. J. Biol. Chem. 243, 2296–2305 (1968).
MEERSON, F.Z. Disturbances of metabolism and cardiac function under the action of emotional painful stress and their prophylaxis. Basic. Res. Cardiol. 75, 479–500 (1980).
NIRDLINGER, E.L. & Bramante, P.O. Subcellular myocardial ionic shifts and mitochondrial alterations in the course of isoproterenol-induced cardiomyopathy of the rat. J. Mol. Cell. Cardiol. 6, 49–60 (1974).
PLAA, G.L. & WITSCHE, H. Chemicals, drugs and lipid peroxidation. Ann. Rev. Pharmacol. 16, 125–141 (1976).
PLACER, Z.A., CUSHMAN, L.L. & JOHNSON, B.C. Estimation of product of lipid peroxidation (Malonyl dialdehyde) in biochemical systems. Anal. Biochem. 16, 359–365 (1966).
RONA, G., CHAPPEL, C.I., BALAZS, T. & Gaudry, R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. A.M.A. Archiv. Pathol. 67, 443–455 (1959).
RONA, G., HUTTNER, I., BOUTET, M. & Badonnel, M.-C. Coronary microcirculatory factors in cardiac muscle cell injury. Recent Advances in Studies on Cardiac Structure and Metabolism. 12, 559–571 (1978).
SACHS, C. & JONSSON, G. Mechanisms of action of 6-hydroxy-dopamine. Biochem. Pharmacol. 24, 1–8 (1975).
SINGAL, P.K., MATSUKUBO, M.P. & DHALLA, N.S. Calcium-related changes in the ultrastructure of mammalian myocardium. Br. J. Exp. Pathol. 60, 96–106 (1979).
SINGAL, P.K., DHILLON, K.S., BEAMISH, R.E. & DHALLA, N.S. Protective effect of zinc against catecholamine-induced myo-cardiac changes: Electrocardiographic and ultrastructural studies. Lab. Invest. 44, 426–433 (1981).
SINGAL, P.K., YATES, J.C., BEAMISH, R.E. & DHALLA, N.S. Influence of reducing agents on adrenochrome-induced changes in the heart. Arch. Pathol. Lab. Med. 105, 664–669 (1981).
SINGAL, P.K., DHILLON, K.S., BEAMISH, R.E., KAPUR, N. & DHALLA, N.S. Myocardial cell damage and cardiovascular changes due to I.V. infusion of adrenochrome in rats. Brit. J. Exp. Pathol. 63, 167–176 (1982).
SINGAL, P.K., KAPUR, N., DHILLON, K.S., BEAMISH, R.E. & DHALLA, N.S. Role of free radicals in catecholamine-induced cardiomyopathy. Can. J. Physiol. Pharmacol.(1982, in press).
TAKENAKA, F. & HUGUCHI, M. High-energy phosphate contents of subendocardium and supepicardium in the rat treated with isoproterenol and some other drugs. J. Mol. Cell. Cardiol. 6, 123–135 (1974).
TAKEO, S., TAAM, G.M.L., BEAMISH, R.E. & DHALLA, N.S. Effect of adrenochrome on calcium accumulation by heart mitochondria. Biochem. Pharmacol. 30, 157–163 (1981).
VALORI, C., THOMAS, M., SHILLINGFORD, J. Free noradrenaline and adrenaline excretion in relation to clinical syndromes following myocardial infarction. Am. J. Cardiol. 20, 605–609 (1967).
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Singal, P.K., Beamish, R.E., Dhalla, N.S. (1983). Potential Oxidative Pathways of Catecholamines in the Formation of Lipid Peroxides and Genesis of Heart Disease. In: Spitzer, J.J. (eds) Myocardial Injury. Advances in Experimental Medicine and Biology, vol 161. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4472-8_22
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