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Continuous Culture for Production

  • Chapter
Basic Biology of New Developments in Biotechnology

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

First I would like to make a personal comment on the general development of biotechnology from the viewpoint of a microbial physiologist. The study of microbial physiology has suffered considerable neglect in recent years and this has implications for the overall pace and direction of biotechnological innovation. In contrast, the effort to understand and manipulate the genomes of microorganisms has attracted massive investment. One of the most remarkable features of microorganisms is their capacity for phenotypic variation, variation which can be manifest in metabolic, chemical, and structural terms. Such variation is a double-edged sword as far as the fermentation microbiologist is concerned: it provides an abundant scope for the development of novel processes but it may pose problems during process scale-up if the fermentation conditions are not sufficiently well reproduced. If one is considering the development of a continuous fermentation process, the difficulties - especially where genetically engineered strains are to be used - may be compounded; the strong selection pressures characteristic of continuous cultures can lead to the competitive displacement of the production strain. The dilemma has been put clearly by Tempest [40] as a basic incompatability between organism improvement by genetic manipulation and process improvement by utilizing continuous culture techniques.

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Author information

Authors and Affiliations

  1. Biological Laboratory, University of Kent at Canterbury, Canterbury, Kent, CT2 7NJ, England

    Alan T. Bull

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  1. Alan T. Bull
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Editors and Affiliations

  1. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

  2. Exxon Research and Engineering Co., Linden, New Jersey, USA

    Allen I. Laskin

  3. University of Minnesota Medical School, Minneapolis, Minnesota, USA

    Palmer Rogers

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© 1983 Plenum Press, New York

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Bull, A.T. (1983). Continuous Culture for Production. In: Hollaender, A., et al. Basic Biology of New Developments in Biotechnology. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4460-5_23

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  • DOI: https://doi.org/10.1007/978-1-4684-4460-5_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4462-9

  • Online ISBN: 978-1-4684-4460-5

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