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DNA Modification and Repair in Vivo: Towards a Biochemical Basis of Organ-Specific Carcinogenesis by Methylating Agents

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Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

The elucidation of the biological basis of organ-specific tumor induction by chemicals is a major objective of cancer research. For many carcinogens, the principal site of tumor induction has been shown to vary with species, dose, route of administration, and age or developmental stage. Some species also exhibit marked differences in their overall susceptibility to certain classes of chemical carcinogens. Accordingly, to accurately predict the adverse effects of genotoxic agents in humans, the basic mechanisms underlying organ and species specificity must first be understood.

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Author information

Authors and Affiliations

  1. Abteilung Neuropathologie, Pathologisches Institut, Universitat Freiburg, Freiburg, Federal Republic of Germany

    Paul Kleihues, Ruth M. Hodgson & Christof Veit

  2. Hygiene Institut, Universitat Tubingen, Tubingen, Federal Republic of Germany

    Fritz Schweinsberg

  3. Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany

    Manfred Wiessler

Authors
  1. Paul Kleihues
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  2. Ruth M. Hodgson
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  3. Christof Veit
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  4. Fritz Schweinsberg
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  5. Manfred Wiessler
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Editor information

Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Kleihues, P., Hodgson, R.M., Veit, C., Schweinsberg, F., Wiessler, M. (1983). DNA Modification and Repair in Vivo: Towards a Biochemical Basis of Organ-Specific Carcinogenesis by Methylating Agents. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_27

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4402-5

  • Online ISBN: 978-1-4684-4400-1

  • eBook Packages: Springer Book Archive

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