Abstract
The complexity of connectivity in the nervous system arises from myriads of associations between different cell types. To investigate the organization of such intricate interconnections the developmental neu-robiologist chooses to dissect individual steps in cell-cell interactions during ontogenesis. The assembly of an elaborate system can then be followed from the simple stages through more complex forms to its final state. Underlying these events are several types of cell behavior such as proliferation, growth, and migration; recognition of cellular, extracellular, or subcellular partner components; and often cell death.
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References
Altman, J., and Anderson, W. J., 1972, Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of all microneurons with prolonged x-irradiation started at birth, J. Comp. Neurol. 146:355.
Berg, G., and Schachner, M., 1981, Immunoelectronmicroscopic identification of O antigen bearing oligodendroglial cells in vitro, Cell Tissue Res. 219:313.
Berwald-Netter, Y., Bizzini, B., Couraud, F., Koulakoff, A., Martin-Montot, N., 1980, Specific surface membrane markers as probes for neuronal evolution in vivo and in vitro. I. Meeting of the International Society for Devel. Neuroscience, p. 279.
Bignami, A., Eng, L. F., Dahl, D., and Uyeda, C. T., 1972, Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence, Brain Res. 43:429.
Campbell, G. LeM., Schachner, M., and Sharrow, S. O., 1977, Isolation of glial cell-enriched and -depleted populations from mouse cerebellum by density gradient centrifugation and electronic cell sorting, Brain Res. 127:69.
Caviness, V., and Rakic, P., 1978, Mechanisms of cortical development: A view from mutations in mice, Ann. Rev. Neurosci. 1:297.
Das, G. D., 1974, Contact guidance and migratory cells in the developing cerebellum, Brain Res. 69:13.
Dimpfel, W., Huang, R. T. C., and Habermann, I., 1977, Gangliosides in nervous tissue and binding of 125I-labelled tetanus toxin, a neuronal marker, J.Neurochem. 29:329.
Eccles, J., Ito, M., and Szentágothai, J., 1967, The Cerebellum as a Neuronal Machine, Springer, Berlin.
Egar, M., and Singer, M., 1972, The role of ependyma in spinal cord regeneration in the urodele, Triturus, J. Exp. Neurol. 37:422.
Eng, L. F., Vanderhaegen, J. J., Bignami, B., and Gerstl, B., 1971, An acidic protein isolated from fibrous astrocytes, Brain Res. 28:351.
Falconer, D. S., 1951, Two new mutants “trembler” and “reeler” with neurological actions in the house mouse (Mus musculus), J. Genet. 50:192.
Franke, W. W., Schmid, E., Osborn, M., Weber, K., 1978, Different intermediate-sized filaments distinguished by immunofluorescence microscopy, Proc. Natl. Acad. Sci. U.S.A. 75:5034.
Franke, W. W., Schmid, E., Osborn, M., and Weber, K., 1979, Intermediate-sized filaments of human endothelial cells, J. Cell Biol. 81:570.
Fujita, S., 1967, Quantitative analysis of cell proliferation and differentiation in the cortex of the postnatal mouse cerebellum, J. Cell Biol. 32:277.
Fujita, S., Shimada, M., and Nakamura, I., 1966, 3H-Thymidine autoradiographic studies on the cell proliferation and differentiation in the external and internal granular layers of the mouse cerebellum, J. Comp. Neurol. 128:191.
Herndon, R. M., 1968, Thiophen induced granule cell necrosis in the rat cerebellum, Exp. Brain Res. 6:49.
Herndon, R. M., Margolis, G., and Kilham, L., 1971a, The synaptic organization of the malformed cerebellum induced by perinatal infection with the feline panleukopenia virus (PLV). I. Elements forming the cerebellar glomeruli, J. Neuropathol. Exp. Neurol. 30:196.
Herndon, R. M., Margolis, G., and Kilham, L., 1971b, The synaptic organization of the malformed cerebellum induced by perinatal infection with the feline panleukopenia virus (PLV), II. The Purkinje cell and its afferents, J. Neuropathol. Exp. Neurol. 30:557.
Hicks, S. P., 1954, The effects of ionizing radiation, certain hormones, and radiomimetric drugs on the developing nervous system, J. Cell. Comp. Physiol. 43(Suppl. 1):151.
Hicks, S. P., and D’Amato, C. J., 1966, Effects of ionizing radiations on mammalian development, in: Advances in Teratology (D. H. M. Woollam, ed.), pp. 196–250, Logos, London.
Hirano, A., Dembitzer, H. M., 1973, Cerebellar alteration in the weaver mouse, J. Cell Biol. 56:478.
His, W., 1889, Neuroblasten und deren Entstehung im embryonalen Mark, Abhandl. Kgl. Saechs. Ges. Wiss. Math. Phys. Kl. 15:313.
Huntington, H. W., and Terry, R. D., 1966, The origin of the reactive cells in cerebral stab wounds, J. Neuropathol. Exp. Neurol. 25:646.
Kilham, L., and Margolis, G., 1966a, Viral etiology of spontaneous ataxia of cats, Am. J. Pathol. 48:991.
Kilham, L., and Margolis, G., 1966b, Spontaneous hepatitis and cerebellar “hypoplasia” in suckling rats due to congenital infections with rat virus, Am. J. Pathol. 49:457.
Köhler, G., and Milstein, C., 1975, Continuous cultures of fused cells secreting antibody of predefined specificity, Nature (London) 256:495.
Köhler, G., and Milstein, C., 1976, Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion, Eur. J. Immunol. 6:511.
Korte, G. E., and Rosenbluth, J., 1980, Membrane specializations in frog ependymal astrocytes, 10th Annual Meeting, Society for Neuroscience, Abstract 247:16.
Kuffler, S., and Nicholls, J. G., 1976, From Neuron to Brain, Sinauer Associates, Sunderland, Mass.
Lagenaur, C., Sommer, I., and Schachner, M., 1980, Subclass of astroglia recognized in mouse cerebellum by monoclonal antibody, Dev. Biol. 79:367.
Lagenaur, C., Master, C., and Schachner, M., 1981, Changes in expression of glial antigens Ml and C1 after cerebellar injury, J. Neuroscience, in press.
Landis, S. C., Mullen, R. J., 1978, The development and degeneration of Purkinje cells in pcd mutant mice, J. Comp. Neurol. 177:125.
Landis, D. M. D., Reese, T. S., 1977, Structure of the Purkinje cell membrane in staggerer and weaver mutant mouse. J. Comp. Neurol. 171:247.
Landis, D. M. D., Sidman, R. L., 1974, Cerebellar cortical development in the staggerer mouse, J. Neuropathol. Exp. Neurol. 33:180.
Lane, P., 1964, Personal communication in Mouse News Letter 30:32.
Llinás, R., 1969, Neurobiology of cerebellar evolution and development, Proceedings of the First International Symposium of the Institute for Biomedical Research, AMA Educational Research Foundation, Chicago, IL.
Mares, V., Lodin, Z., and Srajer, J., 1970, The cellular kinetics of the developing mouse cerebellum. I. The generation cycle, growth fraction and rate of proliferation of the external granular layer, Brain Res. 23:323.
Mariani, J., Crepel, F., Mikoshiba, K., Changeux, J.-P., Sotelo, C., 1977, Anatomical, physiological and biochemical studies of the cerebellum from reeler mutant mouse, Philos. Trans. R. Soc. London 281:1.
Maxwell, D. S., and Krüger, L., 1965, The fine structure of astrocytes in the cerebral cortex and their response to focal injury produced by heavy ionizing particles, J. Cell Biol. 25:141.
Meier, D. H., and Schachner, M., 1982, Immunoselection of oligodendrocytes by magnetic beads. II. In vitro maintenance of immunoselected oligodendrocytes, J. Neuroscience Res., in press.
Meier, D. H., Lagenaur, C, and Schachner, M., 1982, Immunoselection of oligodendrocytes by magnetic beads. I. Determination of antibody coupling parameters and cell binding conditions, J. Neuroscience Res., in press.
Miale, I. L., and Sidman, R. L., 1961, An autoradiographic analysis of histogenesis in the mouse cerebellum, Exp. Neurol. 4:277.
Mirsky, R., Wendon, L., Black, P., Stolkin, C., and Bray, D., 1978, Tetanus toxin: A cell surface marker for neurones in culture, Brain Res. 148:251.
Mugnaini, E., and Forströnen, P. F., 1967, Ultrastructural studies on the cerebellar histogenesis. I. Differentiation of granule cells and development of glomeruli in the chick embryo, Z. Zellforsch. Mikrosk. Anat. Abt. Histochem. 77:115.
Mullen, R. J., and LaVail, M. M., 1975, Two new types of retinal degeneration in cerebellar mutant mice, Nature (London) 258:528.
Mullen, R. J., Eicher, E. M., and Sidman, R. L., 1976, Purkinje cell degeneration, a new neurological mutation in the mouse, Proc. Natl. Acad. Sci. U.S.A. 73:208.
Nathanson, N., Cole, G. A., and Van der Loos, H., 1969, Heterotopic cerebellar granule cells following administration of cyclophosphamide to suckling rats, Brain Res. 15:532.
Nieuwenhuys, R., 1964, Comparative anatomy of the cerebellum, Progr. Brain Res. 25:1.
Nordlander, R. H., and Singer, M., 1978, The role of ependyma in regenaration of the spinal cord in the urodele amphibian tail, J. Comp. Neurol. 180(2):349.
Oksche, A., 1980, Neuroglia I, Springer-Verlag, Berlin.
Palay, S., and Chan-Palay, V., 1974, Cerebellar Cortex Cytology and Organization, Springer-Verlag, New York.
Peters, A., Palay, S. L., and DeF. Webster, H., 1976, The Fine Structure of the Nervous System. The Neurons and Supporting Cells, Saunders, Philadelphia.
Privat, A., 1975, Postnatal gliogenesis in the mammalian brain, Int. Rev. Cytol. 40:281.
Raaf, J., and Kernohan, J. W., 1944, A study of the external granular layer in the cerebellum, Am. J. Anat. 75:151.
Raff, M. C., Brockes, J. P., Fields, K. L., and Mirsky, R., 1979a, Neural cell markers, the end of the beginning, Progr. Brain Res. 51:17.
Raff, M. C., Fields, K. L., Hakomori, S., Mirsky, R., Pruss, R. M., and Winter, J., 1979b, Cell type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture, Brain Res. 174:283.
Rakic, P., 1971, Neuron-glia relationship during granule cell migration in developing cerebellar cortex: A Golgi and electronmicroscopic study in Macacus thesus, J. Comp. Neurol. 141:283.
Rakic, P., 1972, Extrinsic cytological determinants of basket and stellate cell dendritic pattern in the cerebellar molecular layer, J. Comp. Neurol. 146:335.
Rakic, P., 1973, Kinetics of proliferation and latency between final cell division and onset of differentiation of cerebellar stellate and basket neurons, J. Comp. Neurol. 147:523.
Rakic, P., and Sidman, R. L., 1973, Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice, J. Comp. Neurol. 152:133.
Ramón y Cajal, S., 1909–1911, Histologie du Système Nerveux de l’Homme et des Vertébrés, 2 vols. (L. Azoulay, trans.). (Reprinted by Instituto Ramón y Cajal del C.S.I.C., Madrid, 1952–1955).
Ramón y Cajal, S., 1955, Histologie du Système Nerveux, vol 2, C.S.I.C., Madrid.
Rezai, Z., Yoon, C. H., 1972, Abnormal rate of granule cell migration in the cerebellum of “weaver” mutant mice, Dev. Biol. 29:17.
Rohrer, H., and Schachner, M., 1980, Surface proteins of cultured mouse cerebellar cells, J. Neurochem. 35:792.
Schachner, M., and Willinger, M., 1979a, Developmental expression of oligodendrocyte specific cell surface markers: NS-1 (nervous system antigen-1), cerebroside, and basic protein of myelin, in: The Menarini Series on Immunopathology P. A. Miescher, L. Bolis, S. Gorini, T. A. Lambo, G. J. V. Nossal, and G. Torrigiani, eds.), vol. 2, pp. 37–60.
Schachner, M., and Willinger, M., 1979b, Cell type specific cell surface antigens in the cerebellum, Prog. Brain Res. 51:23.
Schachner, M., Wortham, K. A., Carter, L. D., and Chaffee, J. K., 1975, NS-4 (nervous system antigen-4), a cell surface antigen of developing and adult mouse brain and mature sperm, Dev. Biol. 44:313.
Schachner, M., Wortham, K. A., Ruberg, M. Z., Dorfman, S., and LeM. Campbell, G., 1977, Brain cell surface antigens detected by anti-corpus callosum antiserum, Brain Res. 127:87.
Schachner, M., Smith, C., and Schoonmaker, G., 1978a, Immunological distinction between neurofilament and glial fibrillary acidic proteins by mouse antisera and their immunohistological distribution, Dev. Neurosci. 1:1.
Schachner, M., Schoonmaker, G., and Hynes, R. O., 1978b, Cellular and subscellular localization of LETS protein in the nervous system, Brain Res. 158:149.
Schachner, M., Kim, S. K., and Zehnle, R., 1981, Developmental expression in central and peripheral nervous system of oligodendrocyte cell surface antigens (O antigens) recognized by monoclonal antibodies, Dev. Biol. 83:328.
Schaper, A., 1897a, Die frühesten Differenzierungsvorgänge im Centralnervensystem, Arch. Entwicklungsmech. Org. 5:81.
Schaper, A., 1897b, The earliest differentiation in the central nervous system of vertebrates, Science 5:430.
Schmechel, D. E., and Rakic, P., 1979, A Golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes, Anat. Embryol. 156:115.
Schnitzer, J., and Schachner, M., 1979, Isolation and characterization of cell populations of early postnatal mouse cerebellar cortex in vitro, VII International Meeting of the International Society of Neurochemistry, Jerusalem.
Schnitzer, J., and Schachner, M., 1981a, Expression of Thy-1, H-2 and NS-4 cell surface antigens and tetanus toxin receptors in early postnatal and adult mouse cerebellum, J. Neuroimmunol. 1:429.
Schnitzer, J., and Schachner, M., 1981b, Characterization of isolated mouse cerebellar cell populations in vitro, J. Neuroimmunol. 1:457.
Schnitzer, J., and Schachner, M., 1981c, Developmental expression of cell type-specific markers in mouse cerebellar cortical cells in vitro, J. Neuroimmunol. 1:471.
Schnitzer, J., Franke, W. W., and Schachner, M., 1981, Immunocytochemical demonstration of vimentin in astrocytes and ependymal cells of developing and adult mouse nervous system, J. Cell Biol. 90:435.
Shimada, M., and Langman, J., 1970, Repair of the external granular layer after postnatal treatment with 5-fluorodeoxyuridine, Am. J. Anat. 129:247.
Sidman, R. L., 1968, Development of interneuronal connections in brains of mutant mice, in: Physiological and Biochemical Aspects of Nervous Integration (F. D. Carlson, ed.), pp.163–193, Prentice-Hall, Englewood Cliffs, N.J.
Sidman, R. L., Lane, P. W., Dickie, M. M., 1962, Staggerer, a new mutation in the mouse cerebellum, Science 137:610.
Sidman, R. L., Green, M. C., and Appel, S. H., 1965, Catalog of the Neurological Mutants of the Mouse, p. 82, Harvard University Press, Cambridge, Mass.
Smart, I., and Leblond, C. P., 1961, Evidence for division and transformation of neuroglia cells in the mouse brain as derived from radioautography after injection of 3H-thymidine, J. Comp. Neurol. 116:349.
Sommer, I., and Schachner, M., 1981a, 04 antigen-positive and Ol antigen-negative cells are precursors of Ol antigen-positive oligodendrocytes, submitted for publication.
Sommer, I., and Schachner, M., 1981b, Monoclonal antibodies (Ol to 04) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system, Dev. Biol. 83:311.
Sommer, I., and Schachner, M., 1981c, Expression of glial antigens C1 and M1 in developing and adult neurologically mutant mice, J. Supramol. Struct., in press.
Sommer, I., Lagenaur, C., and Schachner, M., 1981, Recognition of Bergmann glial and ependymal cells in the mouse nervous system by monoclonal antibody, J. Cell Biol. 90:448.
Sotelo, C., 1975a, Dendritic abnormalities of Purkinje cells in cerebellum of neurological mutant mice (weaver and staggerer), Adv. Neurol. 12:335.
Sotelo, C., 1975b, Anatomical, physiological and biochemical studies of cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse, Brain Res. 94:19.
Sotelo, C., Changeux, J.-P., 1974a, Transsynaptic degeneration “en cascade” in the cerebellar cortex of staggerer mutant mice, Brain Res. 67:519.
Sotelo, C., Changeux, J.-P., 1974b, Bergmann fibers and granular cell migration in the cerebellum of homozygous weaver mutant mouse, Brain Res. 77:484.
Tapscott, S. J., Bennett, G. S., and Holtzer, H., 1980, Transition between intermediate filament types during neurogenesis, J. Cell Biol. 87:181a.
Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J.-M., and Martin, G. R., 1979, Laminin—A glycoprotein from basement membranes, J. Biol. Chem. 254:9933.
Uzman, L. L., 1960, The histogenesis of the mouse cerebellum as studied by its tritiated thymidine uptake, J. Comp. Neurol. 114:137.
Van Heyningen, W. E., 1963, The fixation of tetanus toxin, strychnine, serotonin and other substances by ganglioside, J. Gen. Microbiol. 31:375.
Vaughn, J. E., Hinds, P. L., and Skoff, R. P., 1970. Electron microscopic studies of Wallerian degeneration in rat optic nerves. I. The mutipotential glia, J. Comp. Neurol. 140:175.
Webster, W., Shimada, M., and Langman, J., 1973, Effect of fluorodeoxyuridine, colcemid, and bromodeoxyuridine on developing neocortex of the mouse, Am. J. Anat. 137:67.
Willinger, M., and Schachner, M., 1978, Distribution of Gm1 ganglioside in developing cerebellum, J. Supramol. Struct. Suppl. 2:128.
Willinger, M., and Schachner, M., 1980, Gm1 ganglioside as a marker for neuronal differentiation in mouse cerebellum, Devel. Biol. 74:101.
Zalc, B., Monge, M., Dupouey, P., Hauw, J. J., and Baumann, N. A., 1981, Immuno-histochemical localization of galactosyl- and sulfogalactosylceramide in the brain of 30-day-old mouse, Brain Res. 211:341.
Zamenhof, S., Grauel, L., and van Marthens, E., 1971, The effect of thymidine and 5-bromodeoxyuridine on developing chick embryo brain, Res. Commun. Chem. Pathol. Pharmacol. 2:261.
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Schachner, M. (1982). Immunological Analysis of Cellular Heterogeneity in the Cerebellum. In: Brockes, J. (eds) Neuroimmunology. Current Topics in Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4190-1_8
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