Skip to main content

Application of Somatosensory Event Related Potentials to Experimental Pain and the Pharmacology of Analgesia

  • Chapter
Human Evoked Potentials

Part of the book series: NATO Conference Series ((HF,volume 9))

Abstract

There is increasing evidence that many neurotransmitter systems may be involved in pain appreciation including cholinergic agents, endorphins, biogenic amines and others (Mayer and Price, 1976). This suggests that there are multiple mediators of pain appreciation, each involving a possibly distinct neural pathway. Event related potentials may offer a means of separating distinct pain modulation processes in phamacological experiments in man.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Buchsbaum, M.S., Davis, G.C. and Bunney, W.E., Jr. Naloxone alters pain perception and somatosensory evoked potentials in normal subjects. Nature, 1977, 270, 620–622.

    Article  PubMed  CAS  Google Scholar 

  • Buchsbaum, M.S. Self-regulation of stimulus intensity: Augmenting/ reducing and the average evoked response. In G.E. Schwartz and D. Shapiro (Eds.), Consciousness and Self-Regulation, New York: Plenum Press, 1976.

    Google Scholar 

  • Buchsbaum, M.S. Average evoked response augmenting/reducing in schizophrenia and affective disorders. In D.X. Freedman (Ed.), The Biology of the Major Psychoses, A Comparative Analysis, New York: Raven Press, 1975.

    Google Scholar 

  • Chapman, C. R., Murphy, T.M. and Butler, S. Analgesic strength of 33 percent nitrous oxide: A signal detection theory evaluation. Science, 1973, 179, 1246–1248.

    Article  PubMed  CAS  Google Scholar 

  • Clark, W.C. and Goodman, J. Effects of suggestion on d’ and cx for pain detection and pain tolerance. J. Abnorm. Psychol., 1974, 83, 364–372.

    Article  PubMed  CAS  Google Scholar 

  • Coppola, R. Isolating low frequency activity in EEG spectrum analysis. Electroenceph. Clin. Neurophysiol., in press.

    Google Scholar 

  • Goff, G.D., Matsumiya, Y., Allison, T. and Goff, W.R. The scalp topography of human somatosensory and auditory evoked potentials. Electroenceph. Clin. Neurophysiol., 1977, 42, 57–76.

    Article  PubMed  CAS  Google Scholar 

  • Lavine, R., Buchsbaum, M.S. and Poncy, M. Auditory analgesia: Somatosensory evoked response and siabjective pain rating. Psycho- physiol., 1976, 13, 140–148.

    CAS  Google Scholar 

  • Levy, R. and Mushin, J. The somatosensory evoked response in patients with hysterical anaesthesia. U. Psychosom. Res., 1973, 17, 81–84.

    Article  CAS  Google Scholar 

  • Lykken, D.T., Macindoe, I. and Teilegen, A. Perception: Autonomic response to shock as a function of predictability in time and locus. Psychophysiol., 1972, 9, 318–333.

    Article  CAS  Google Scholar 

  • Mayer, D.J. and Price, D.D. Central nervous system mechanism of analgesia. Pain, 1976, 2, 379–404.

    Article  PubMed  CAS  Google Scholar 

  • Mushin, J. and Levy, R. Averaged evoked response in patients with psychogenic pain. Psychol. Med., 1974, 4, 19–27.

    Article  PubMed  CAS  Google Scholar 

  • Satran, R. and Goldstein, M. Pain perception: Modification of threshold of intolerance and cortical potentials by cutaneous stimulation. Science, 1973, 180, 1201–1202.

    Article  PubMed  CAS  Google Scholar 

  • Sitaram, N., Buchsbaum, M.S. and Gillin, J.C. Physostigmine analgesia and somatosensory evoked responses in man. Europ. J. Pharm., 1977, 42, 285–290.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Buchsbaum, M.S., Davis, G.C. (1979). Application of Somatosensory Event Related Potentials to Experimental Pain and the Pharmacology of Analgesia. In: Lehmann, D., Callaway, E. (eds) Human Evoked Potentials. NATO Conference Series, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3483-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3483-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3485-9

  • Online ISBN: 978-1-4684-3483-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics