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Reversion of Malignancy and Normalized Differentiation of Teratocarcinoma Cells in Chimeric Mice

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Genetic Mosaics and Chimeras in Mammals

Part of the book series: Basic Life Sciences ((BLSC,volume 12))

Abstract

In this review, I should like briefly to summarize some new approaches in experimental research on mouse teratocarcinomas. During the past few years, these tumors have been tested for their developmental potential, genetic constitution, and state of neoplastic transformation in the living organism, using microsurgery to introduce the malignant stem cells into early mouse embryos. What exactly are teratocarcinomas, and why are they becoming such a useful tool in analyzing gene expression during mammalian differentiation?

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Authors and Affiliations

  1. Department of Biology, University of Geneva, Switzerland

    Karl Illmensee

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  1. Karl Illmensee
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Editors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Liane B. Russell

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© 1978 Plenum Press, New York

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Illmensee, K. (1978). Reversion of Malignancy and Normalized Differentiation of Teratocarcinoma Cells in Chimeric Mice. In: Russell, L.B. (eds) Genetic Mosaics and Chimeras in Mammals. Basic Life Sciences, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3390-6_1

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  • DOI: https://doi.org/10.1007/978-1-4684-3390-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3392-0

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