Abstract
The primary sequelae of cerebral ischemia are due to the lack of adequate blood circulation, which is the cause of insufficient supply of oxygen and nutrients to the brain. This circulatory disturbance is also one of the greatest obstacles to direct in vivo studies of processes involved in the transport of substrates into and out of the brain. Therefore, our previous investigations concerned with glucose transport in cerebral ischemia were performed at various periods following the reestablishment of cerebral blood circulation (11, 12, 14). Moreover, these limitations on the in vivo studies and the fact that the observed transport phenomena could have occurred in one or more sites such as capillary endothelium, glia and neurons have led so far to separate investigations of the cerebral microvessels and synapto-somes function.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aveldano, M. I. and Bazan, N. G., Jr. (1975): Rapid production of diacylglycerols enriched in arachnido-nate and stearate during early brain ischemia. J. Neurochem. 25: 919–920.
Bazan, N. G., Jr. (1971): Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia. J. Neurochem. 18: 1379–1385.
Betz, A. L., Gilboe, D. D. and Drewes, L. R. (1975): Kinetics of unidirectional leucine transport into brain: effects of isoleucine, valine, and anoxia. Am. J. Physiol. 228: 895–900.
Chaplin, E. R., Goldberg, A. L. and Diamond, I. (1976): Leucine oxidation in brain slices and nerve endings. J. Neurochem. 26: 701–707.
Galli, C. and Spaguolo, C. (1976): The release of brain free fatty acids during ischemia in essential fatty acid deficient rats. J. Neurochem. 26: 401–404.
Lajtha, A. (1968): Transport as control mechanism of cerebri metabolite levels. Prog. Brain Res. 29: 201–214.
Lajtha, A. and Sershen, H. (1975): Inhibition of amino acid uptake by the absence of Na in slices of brain. J. Neurochem. 24: 667–672.
Lajtha, A. and Toth, J. (1961): The brain barrier system — II Uptake and transport of amino acids by the brain. J. Neurochem. 8: 216–225.
Mićić, D., Mićić, J., Swink, M. E. and Spatz, M. (1978): The anoxic effect on 2-deoxy-D-[3H]glucose uptake in the isolated cerebral capillaries. Proc. Soc. Exp. Biol. Med. 158: 318–322.
Quastel, J. H. (1965): Molecular transport at cell membranes. Proc. R. Soc. London (Biol.) 163: 169–196.
Spatz, M., Berson, F., Fujimoto, T. and Klatzo, I. (1976): Transport of nutrients and non-nutrients across the blood-brain barrier in pathological conditions. In: The Cerebral Vessel Wall, Cervós-Navarro, J., ed. Raven Press, New York, 225–232.
Spatz, M., Go, G. K. and Klatzo, I. (1974): The effect of ischemia.on the brain uptake of [14C]glucose analogues and [14C]sucrose. In: Pathology of Cerebral Microcirculation, Cervós-Navarro, J., ed. Walter de Gruyter & Co., Berlin, 361–336.
Spatz, M., Mršulja, B. B., Mršulja, B. J. and Klatzo, I. (1976): Recovery of decreased synaptosomal 2-deoxy-D-[3r]glucose uptake after cerebral ischemia in Mongolian gerbils. Brain Res. 103: 193–198.
Spatz, M., Fujimoto, T. and Go, G. K. (1976): Transport studies in ischemic cerebral edema. In: Dynamics of Brain Edema, Pappius, H. M. and Feindel, W., eds. Springer-Verlag, Berlin-Heidelberg-New York, 181–186.
Spatz, M., Mršulja, B. B., Mićić, D., Mršulja, B. J. and Klatzo, I. (1977): Ischemic and post-ischemic effects on 2-deoxy-D-[3H] glucose uptake in cerebral capillaries. Brain Res. 120: 141–145.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Press, New York
About this chapter
Cite this chapter
Spatz, M., Mićić, D., Fujimoto, T., Mršulja, B.B., Klatzo, I. (1979). Transport Phenomena in Cerebral Ischemia. In: Mršulja, B.B., Rakić, L.M., Klatzo, I., Spatz, M. (eds) Pathophysiology of Cerebral Energy Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3348-7_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3348-7_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3350-0
Online ISBN: 978-1-4684-3348-7
eBook Packages: Springer Book Archive