Skip to main content
SpringerLink
Log in

Nitroblue Tetrazolium Reduction by Human Macrophages: Studies in Chronic Granulomatous Disease

  • Chapter
The Reticuloendothelial System in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 73))

Abstract

Properties and functions of macrophages have been extensively studied in animals, but little work has been done in humans because of the difficulties in obtaining a homogeneous and adequate mononuclear phagocyte population. Nitroblue tetrazolium (NBT) has been largely used with polymorphonuclear leukocytes (PMNL) to study the functions of phagocytes (12,16,21). This method can reveal some congenital defects of PMNL such as in chronic granulomatous disease (CGD) where intracellular killing of microorganisms is impaired (22).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adam, D., Schaffert, W. and Marget, W., Infect. Immun., 9 (1974) 811.

    PubMed  CAS  Google Scholar 

  2. Bennett, W.E. and Cohn, Z.A., J. Exp. Med., 123 (1966) 145.

    Article  PubMed  CAS  Google Scholar 

  3. Cline, M.J. and Lehrer, R.I., Blood, 32 (1968) 423.

    PubMed  CAS  Google Scholar 

  4. Cline, M.J., Infect. Immun., 2 (1970) 156.

    PubMed  CAS  Google Scholar 

  5. Cohn, Z.A. and Benson, B., J. Exp. Med., 121 (1965) 153.

    Article  PubMed  CAS  Google Scholar 

  6. Davis, W.C., Huber, H., Douglas, S.D. and Fudenberg, H.H., J. Immunol., 101 (1968) 1093.

    Google Scholar 

  7. Diamond, R.D. and Bennett, J.E., Infect. Immun., 7 (1973) 231.

    PubMed  CAS  Google Scholar 

  8. Furth, R. Van, Sem. Hematol., 7 (1970) 125.

    Google Scholar 

  9. Gifford, R.H. and Malawista, S.E., Yale J. Biol. Med., 45 (1972) 119.

    PubMed  CAS  Google Scholar 

  10. Heyden, H.W. and Heyden, D., Blat., 2 (1974) 1.

    Google Scholar 

  11. Holmes, B., Page, A.R. and Good, R.A., J. Clin. Invest., 46 (1967) 1422.

    Google Scholar 

  12. Karnovsky, M.L., Lazdins, J. and Simmons, S.R., Mononuclear Phagocytes (Ed. R. Van Furth) Blackwell Scientific Publications, Oxford, England (1975) 423.

    Google Scholar 

  13. Klebanoff, S.J. and Hamon, C.B., Mononuclear Phagocytes (Ed. R van Furth) Blackwell Scientific Publications, Oxford, England (1975) 507.

    Google Scholar 

  14. Krishnan, A.D. and Talwar, G.P., Indian J. Med. Res., 62 (1974) 313.

    PubMed  CAS  Google Scholar 

  15. Lehrer, R.I., J. Clin. Invest., 55 (1975) 338.

    Article  PubMed  CAS  Google Scholar 

  16. Nathan, D.G., Baehner, R.L. and Weaver, D.K., J. Clin. Invest., 48 (1969) 1895.

    Google Scholar 

  17. Nydegger, V.E., Miescher, A., Anner, R.M., Creighton, D.W., Lambert, P.H. and Miescher, P.A., Klin. Wosch., 51 (1973) 377.

    Article  CAS  Google Scholar 

  18. Odegaard, A., Viken, K.E. and Lamvik, J., Acta Path. Microbiol. Scand. Sect. B, 82 (1974) 223.

    CAS  Google Scholar 

  19. Park, B.H., Biggar, W.D., L’Esperance, P. and Good, R.A., Lancet, 1 (1972). 1064.

    Article  PubMed  CAS  Google Scholar 

  20. Park, B.H., Fikrig, S.M. and Smithwick, E.M., Lancet, 1 (1968) 532

    Article  Google Scholar 

  21. Preisig, E. and Hitzig, W.H., Europ. J. Clin. Invest., 1 (1971) 409.

    Article  PubMed  CAS  Google Scholar 

  22. Quie, P.G., White, J.G., Holmes, B. and Good, R.A., J. Clin. Invest., 46 (1967) 668.

    Article  PubMed  CAS  Google Scholar 

  23. Rodey, G.E., Park, B.H., Windhorst, D.B. and Good, R.A., Blood, 33 (1969) 813.

    PubMed  CAS  Google Scholar 

  24. Rossi, F., Zabucchi, G. and Romeo, D., Mononuclear Phagocytes (Ed. R. Van Furth) Blackwell Scientific Publications, Oxford, England (1975) 441.

    Google Scholar 

  25. Steigbigel, R.T., Lambert, L.H. and Remington, J.S., J. Clin. Invest., 53 (1974) 131.

    Article  PubMed  CAS  Google Scholar 

  26. Strauss, R.R., Paul, B.B. and Sbarra, A.J., J. Bacteriol., 96 (1968) 1982.

    Google Scholar 

  27. Sutton, J.S. and Weiss, L., J. Cell Biol., 28 (1966) 303.

    Article  PubMed  CAS  Google Scholar 

  28. Urbanitz, D., Nolden, H.P., Fechner, I., Urbanitz, S., Freiberg, J. and Sieberth, H.G., Klin. Wooch., 53 (1975) 59.

    Article  CAS  Google Scholar 

  29. Viken, K.E. and Odegaard, A., Acta Path. Microbiol. Scand. Sect. B, 82 (1974) 235.

    CAS  Google Scholar 

  30. Vildé, J.L., Annales Inst. Pasteur, 120 (1971) 382.

    Google Scholar 

  31. Vildé, J.L. and Lagrange, P., Rev. Fr. Mal. Respiratoires, 2 (1974) 57.

    Google Scholar 

  32. Vildé, F. and Nezelof, C., Path. Biol., 21 (1973) 629.

    Google Scholar 

  33. Vildé, J.L. and Lagrange, P., Annales Immunol. (in press).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hôpital Claude Bernard, Université Paris 7, Paris, France

    J. L. Vildé

  2. Hôpital Boucicaut, Université Paris 5, Paris, France

    F. Vildé

Authors
  1. J. L. Vildé
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Vildé
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  2. Medical College of Virginia, Richmond, Virginia, USA

    Mario R. Escobar

  3. Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA

    Herman Friedman

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Vildé, J.L., Vildé, F. (1976). Nitroblue Tetrazolium Reduction by Human Macrophages: Studies in Chronic Granulomatous Disease. In: Reichard, S.M., Escobar, M.R., Friedman, H. (eds) The Reticuloendothelial System in Health and Disease. Advances in Experimental Medicine and Biology, vol 73. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3297-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3297-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3299-2

  • Online ISBN: 978-1-4684-3297-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation