Abstract
Secondary hyperuricemias in hematological diseases are frequently related to an increased turnover of nucleic acid purine in rapidly proliferating cells or in hyperplastic tissue (1). Transient hyperuricemia, hyperuricosuria and acute gouty arthritis have occurred during liver extract induced reticulocytosis and during the therapy for deficiencies of folic acid or iron (1–4). To further explore the acute alterations of purine metabolism, we have investigated 7 patients with severe megaloblastic anemia for changes of uric acid metabolism and 3 important erythrocyte enzymes of purine metabolism (5).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Talbott, J.H. 1959. Gout and blood dyscrasias. Med. 38:173–205.
Riddle, M.C. 1930. The endogenous uric acid metabolism in pernicious anemia. J. Clin. Invest. 8: 69–88.
Opsahl, R. 1939. Hematopoiesis and endogenous uric acid. Acta Med. Scand. 102:611–628.
Krafka, J. Jr. 1929. Endogenous uric acid and hematopoiesis II uric acid, reticulocytosis and erythrocytes after hemolysis by Phenylhydrazine hydrochloride. J. Biol. Chem. 83:409–414.
Fox, I.H., Dotten, D.A., Marchant, P.J. and Lacroix, S. 1976. Acquired increases of human erythrocyte purine enzymes. Metabolism 25:571–582.
Luhby, A.L. and Cooperman, J.M. 1962. Aminoimidazolecarboxamide excretion in Vitamin -B12 and folic acid deficiencies. Lancet 2: 1381–1382.
Smith, L.H. and Baker, F.A. 1960. Pyrimidine metabolism in man. III Studies on leukocytes and erythrocytes in pernicious anemia. J. Clin. Invest. 39:15–20.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Fox, I.H., Dotten, D.A., Marchant, P.J. (1977). Alterations of Human Purine Metabolism in Megaloblastic Anemia. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology, vol 76B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3285-5_36
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3285-5_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3287-9
Online ISBN: 978-1-4684-3285-5
eBook Packages: Springer Book Archive