Summary
The chicken is a good animal model for the study of atherosclerosis research because it is:
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1.
Omnivorous.
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2.
Small and suitable for prolonged laboratory investigation.
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3.
Able to develop spontaneous atherosclerosis.
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4.
Capable of producing atherosclerosis after cholesterol feeding with elevated hypercholesterolemia. A diet of 1/4% cholesterol plus 5% cottonseed oil added to starter-grower-mash resulted in aortic atherosclerosis with a slight but significant increase in plasma cholesterol.
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5.
Plasma levels of cholesterol and triglyceride are similar to those in humans.
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6.
Lipid composition of high and low density lipoproteins as well as chylomicrons resembles those of humans.
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7.
Has been noted that there is no essential difference between vascular lesions seen in chickens as a result of cholesterol diet and that of atherosclerosis observed in man.
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© 1975 Plenum Press, New York
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Wong, H.Y.C. (1975). The Cockerel as an Animal Model for Atherosclerosis Research. In: Kritchevsky, D., Paoletti, R., Holmes, W.L. (eds) Lipids, Lipoproteins, and Drugs. Advances in Experimental Medicine and Biology, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3258-9_29
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