Abstract
Life is a continuous process; a live ovum and spermatozoon unite to form a human being like, yet not identical, with any other member of the species. These host differences offer opportunity for variability in reaction to a noxious drug. The life span — from conception to old age — is divided biologically and on other grounds into quite different periods rather clearly separated from each other. This presents another host basis for variability to a drug’s effects.
Revised from: Shirkey, H.C. (Ed.), Pediatric Therapy (4th ed.) 1972, C.V. Mosby Co., St. Louis, Mo.
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Shirkey, H.C. (1972). Human Experiences Related to Adverse Drug Reactions to the Fetus or Neonate from Some Maternally Administered Drugs. In: Klingerg, M.A., Abramovici, A., Chemke, J. (eds) Drugs and Fetal Development. Advances in Experimental Medicine and Biology, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3219-0_3
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