Abstract
Cocaine is known to be a local anesthetic and a potent CNS stimulant. Several reports indicate an increase in locomotor activity with low acute doses of the drug, and involvement of brain amines in this psychomotor stimulation has been proposed (Van Zwieten, Widhalm, and. Hertting, 1965; Groppetti, 1974).
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References
Anton, A.H. and Sayre, D.F.: A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines, J. Pharmac. exp. Ther. 138, 360–375 (1962).
Browne, R.G., Harris, R.T., and Ho, B.T.: Stimulus properties of mescaline and n-methylated derivatives: Difference in peripheral and direct central administration, Psychopharmacologia 39, 43–56 (1974).
Caldwell, J. and Sever, P.: The biochemical pharmacology of abused drugs. I. Amphetamines, cocaine and LSD, Clin. Pharmacol. Therap. 16, 625–638 (1974).
Coyle, J.T. and Snyder, S.H.: Catecholamine uptake by synaptosomes in homogenates of rat brain: Stereospecificity in different areas, J. Pharmac. exp. Ther. 170, 221–231 (1969).
Curzon, G. and Green, A.R.: Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain, Br. J. Pharmacol. 39, 653–655 (1970).
Downs, A.W. and Eddy, N.B.: The effects of repeated doses of cocaine on the rat, J. Pharmac. exp. Ther. 46, 199–200 (1932).
Groppetti, A., Zambotti, F., Biazzi, A., and Mantegazza, P.: Amphetamine and cocaine on amine turnover. In: Frontiers in Catecholamine Research. Usdin, E. and Snyder, S., Eds., pp. 917–925. New York: Pergamon, 1974.
Gutierrez-Noriega, C. and Zapata-Ortiz, V.: Cocainismo experimental. I. Toxicologia general, acostumbramiento y sensibilizacion, Revta Med. exp. 3, 280–306 (1944).
Huang, J.T. and Ho, B.T.: Discriminative stimulus properties of d-amphetamine and related compounds in rats, Pharmac. Biochem. Behay. 2, 669–673 (1974).
Kosman, M.E. and Unna, K.R.: Effects of chronic administration of the amphetamines and other stimulants on behavior, Clin. Pharmacol. Therap. 9, 240–254 (1968).
Laverty, R. and Taylor, K.M.: The fluorometric assay of catecholamines and related compounds, Anal. Biochem. 22, 269–279 (1968).
Lovenberg, W., Jequier, E., and Sjoerdsma, A.: Tryptophan hydroxylation: Measurement in pineal gland, brainstem and carcinoid tumor, Science 155, 217–219 (1967).
McCaman, M.W., McCaman, R.E., and Lees, G.J.: Liquid cation exchange–a basis for sensitive radiometric assays for aromatic amino acid decarboxylases, Anal. Biochem. 45, 242–252 (1972).
Post, R.M. and Kopanda, R.T.: Cocaine, kindling and reverse tolerance, Lancet i, 409–410 (1975).
Randrup, A. and Scheel-Krüger, J.: Diethyldithio carbamate and amphetamine stereotype behavior, J. Pharm. Pharmac. 18, 752 (1966).
Schellenberger, M.K. and Gordon, J.H.: A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine and 5-hydroxytryptamine from discrete brain areas, Anal. Biochem. 39, 356–371 (1971).
Schubert, J., Fyrö, B., Nybäck, H., and Sedvall, G.: Effects of cocaine and amphetamine on the metabolism of tryptophan and 5-hydroxytryptamine in mouse brain in vivo, J. Pharm. Pharmac. 22, 860–862 (1970).
Van Zwieten, P.A., Widhalm, S., and Hertting, G.J.: Influence of cocaine and of pretreatment with reserpine on the pressor effect and the tissue uptake of injected dl-catecholamines-2–3H, J. Pharmac. exp. Ther. 149, 50–56 (1965).
Waymire, J.C., Bjur, R., and Weiner, N.: Assay of tyrosine hydroxylase by coupled decarboxylation of dopa formed from 1–14C-Ltyrosine, Anal. Biochem. 43, 588–600 (1971).
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© 1977 Plenum Press, New York
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Ho, B.T., Taylor, D.L., Estevez, V.S., Englert, L.F., Mckenna, M.L. (1977). Behavioral Effects of Cocaine--Metabolic and Neurochemical Approach. In: Ellinwood, E.H., Kilbey, M.M. (eds) Cocaine and Other Stimulants. Advances in Behavioral Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3087-5_12
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DOI: https://doi.org/10.1007/978-1-4684-3087-5_12
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