Abstract
Intercommunication between neurons involves neurotransmitter substances which: (a) are synthesized and stored in the presynaptic neuron, (b) are released by the arrival of the impulse; and (c) act on the postsynaptic neurons. The molecular events occurring presynaptically, at the synaptic cleft, or on the postsynaptic membrane are among the most intensively studied subjects in neurobiology. Whereas considerable knowledge exists about the adult CNS, information concerning the differentiation of neurotransmisstion mechanisms during development has only recently begun to accumulate.
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References
Bayliss, B.J., and Todrick, A., 1956, The use of a selective acetyl-cholinesterase inhibitor in the estimation of pseudocholinesterase activity in rat brain, Biochem. J. 62: 62.
Clark, R.B. and Perkins, J.P., 1971, Regulation of adenosine 3’:5’-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine, Proc. Nat. Acad. Sci. 68: 2757.
Corner, M.A. and Bot, A.P.C., 1967, Developmental patterns in the central nervous system of birds. II. Somatic motility during the embryonic period and its relation to behavior after hatching, Progr. Brain Res. 26: 214.
Corner, M.A., Schadand J.P., Sedlâcek, J., Stoeckart, R., and Bot, A.P.C., 1967, Developmental patterns in the central nervous system of birds. I. Electrical activity in the cerebral hemisphere, optic lobe and cerebellum, Progr. Brain Res. 26: 145.
Davis, J.M., Goodwin, F.K., Bunney, W.E., Murphy, D.L., and Colburn, R.W., 1967, Effects of ions in uptake of norepinephrine by synaptosomes, Pharmacologist 9: 184.
Dengler, J.J., Michaelson, I.A., Spiegai, H.E. and Titus, E., 1962, The uptake of labelled norepinephrine by isolated brain and other tissues of the cat, Int. J. Neuropharmacol. 1: 23.
De Vellis, J., Inglish, D., and Galey, F., 1971, Effects of cortisol and epinephrine on glial cells in culture, in: “Cellular Aspects of Neural Growth and Differentiation”, ( D. Pease, ed.) UCLA Forum in Medical Sciences, University of California Press.
Ellman, G.L., Courtney, K.D., Andres, V., and Featherstone, R.M., 1961, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem. Pharmacology 7: 88.
Filogamo, G. and Marchisio, P.C., 1971, Acetylcholine system and neural development, Neurosciences 4: 29.
Fritz, A.H. and Hamburger, A., 1971, Glial cell function: Uptake of transmitter substances, Proc. Nat. Acad. Sci. 68: 2686.
Giacobini, E., 1964, Metabolic relations between glia and neurons studied in single cells, in: “Morphological and Biochemical Correlates of Neural Activity,” ( Cohen and Snider, eds.), Hoeber, New York.
Hanaway, J., 1967, Formation and differentiation of the external granular layer of the thick cerebellum, J. Comp. Neurol. 131: 1.
Hornykiewicz, O., 1966, Dopamine (3-hydroxytryptamine) and brain function, Pharmacol. Rev. 18: 925.
Iversen, L.L., 1971, Role of transmitter uptake mechanisms in synaptic neurotransmission, Br. J. Pharmacol. 41: 571.
Iversen, L.L. and Salt, P.J., 1970, Inhibition of catecholamine Uptake2 by steroids in the isolated rat heart, Br. J. Pharmacol. 40: 528.
Kellogg, C., Vernadakis, A. and Rutledge, C.O., 1971, Uptake and metabolism of 3H-norepinephrine in the cerebral hemispheres of chick embryos, J. Neurochem. 18: 1931.
Maickel, R.P., Cox, R.H., Jr., Sailant, J. and Miller, F.P., 1968, A method for the determination of serotonin and norepinephrine in discrete areas of rat brain, Int. J. Neuropharmacol. 7: 275.
Renson, J., 1971, Development of monaminergic transmission in the rat brain in “Chemistry and Brain Development”, (Paoletti and Davison, eds.), Plenum Press, New York.
Rutledge, C.O., 1970, The mechanisms by which amphetamine inhibits oxidative deamination of norepinephrine in brain, J. Pharmacol. Exp. Ther. 171: 188.
Rutledge, C.O. and Jonason, J., 1967, Metabolic pathways of dopamine and norepinephrine in rabbit brain in vitro, J. Pharmacol. Exp. Ther. 157: 493.
Snyder, S.H. and Coyle, J.T., 1969, Regional differences in 3Hnorepinephrine and 3H-dopamine uptake into rat brain homogenates, J. Pharmacol. Exp. Ther. 165: 78.
Snyder, S.H., Green, A.I. and Hendley, E.D., 1968, Kinetics of 3Hnorepinephrine accumulation into slices from different regions of rat brain, J. Pharmacol. Exp. Ther. 164: 90.
Vernadakis, A., 1973a, Comparative studies of neurotransmitter substances in the maturing and aging central nervous system of the chicken, in “Neurobiological Aspects of Maturation and Aging,” (Ford, ed.), Elsevier, Amsterdam, in press.
Vernadakis, A., 1973b, Changes in nucleic acid content and butyrylcholinesterase activity in CNS structures during the life-span of the chicken, J. Gerontology: 28: 281.
Vernadakis, A. and Burkhalter, A., 1965, Convulsive responses in developing chickens, Proc. Soc. Exper. Biol. & Med. 119: 512.
Vernadakis, A. and Burkhalter, B., 1967, Acetylcholinesterase activity in optic lobes of chicks at hatching, Nature 214: 594.
Vernadakis, A. and Gibson, D.A., 1973a, Role of neurotransmitter sub- stances in neural growth, in “Conference on The Problems and Priorities in Perinatal Pharmacology” sponsored by National Institute of Child Health, April 12–14, 1973, Raven Press, in press.
Vernadakis, A. and Gibson, D.A., 1973b, Chemical properties of neuronal and glial fractions isolated from chicks early post-hatching. Abstract of paper presented at the 4th Inter. Meeting of the Inter. Soc. for Neurochemistry, Aug. 26–31, 1973, Tokyo, Japan.
Vernadakis, A. and Woodbury, D.M., 1971a, Influence of cortisol on brain and spinal cord excitability in developing rats, in “Steroid Hormones and Brain Function”, (Sawyer and Gorski, eds.) UCLA Forum in Medical Sciences, University of California Press.
Vernadakis, A. and Woodbury, D.M., 1971b, Effects of cortisol on maturation of the central nervous system, in “Influence of Hormones on the Nervous System”, (Ford, ed.), Proc. Intern. Soc. of Psychoneuroendocrinology, S. Karger, Basel, New York.
Vos, J., Schadé, J.P., and Van Der Helm, 1967, Developmental patterns in the central nervous system of birds. II. Some biochemical parameters of embryonic and post-embryonic maturation, Progr. Brain Res. 26: 193.
Ziance, R.H. and Rutledge, C.O., 1972, A comparison of the effects of fenfluramine and amphetamine on uptake, release and catabolism of norepinephrine in brain, J. Pharmacol. Exp. Ther. 180: 118.
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Vernadakis, A. (1974). Uptake and Storage of 3H-Norepinephrine in the Cerebral Hemispheres and Cerebellum of Chicks during Embryonic Development and Early Posthatching. In: Vernadakis, A., Weiner, N. (eds) Drugs and the Developing Brain. Advances in Behavioral Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3063-9_7
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DOI: https://doi.org/10.1007/978-1-4684-3063-9_7
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