Abstract
The effect of bulk flow of cerebrospinal fluid on the distribution of substances in the central nervous system has been a problem appreciated especially by those who have attempted to quantify the interstitial volume of the brain. The implications of this so-called “CSF sink” effect, particularly with regard to the measurement of brain extracellular space, have been treated thoroughly in reviews by Davson (1965) and by Woodbury (1967).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dayson, H., 1965, The extracellular space of the brain, in “Progress in Brain Research,” Vol 12, (E.D.P. De Robertis and R. Carrea, eds.), pp. 124–134, Elsevier Publishing Co., Amsterdam, London and New York.
Ferguson, R.K., and Woodbury, D.M., 1969, Penetration of 14C-inulin and 14C-sucrose into brain, cerebrospinal fluid, and skeletal muscle of developing rats, Exp. Brain Res. 7: 181.
Holloway, L.S., and Cassin, S., 1972, Cerebrospinal fluid dynamics in the newborn dog during normoxia and hypoxia, Am. J. Physiol. 223: 499.
Vernadakis, A., and Woodbury, D.M., 1965, Cellular and extracellular spaces in developing rat brain, Arch. Neurol. 12: 284.
Woodbury, D.M., 1967, Distribution of nonelectrolytes and electrolytes in the brain as affected by alterations in cerebrospinal fluid secretion, in “Progress in Brain Research,” Vol. 29, (A. Lajtha and D. Ford, eds.), pp. 297–313, Elsevier Publishing Co., Amsterdam.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Plenum Press, New York
About this chapter
Cite this chapter
Johanson, C.E., Woodbury, D.M. (1974). Changes in CSF Flow and Extracellular Space in the Developing Rat. In: Vernadakis, A., Weiner, N. (eds) Drugs and the Developing Brain. Advances in Behavioral Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3063-9_15
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3063-9_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3065-3
Online ISBN: 978-1-4684-3063-9
eBook Packages: Springer Book Archive