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Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs

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Prostaglandins in Cellular Biology

Part of the book series: Alza Conference Series ((ALZA,volume 1))

Abstract

When studying the pharmacological mediation of an inflammatory reaction, several difficulties are encountered. These lie in the multiplicity of factors involved and the complexity of their interactions. However, there are rigid criteria which ought to be satisfied before a substance can be definitely classified as a mediator of inflammation; these are listed below:

  1. (1)

    The putative mediator of inflammation should induce some or all of the signs of inflammation.

  2. (2)

    During the inflammatory reaction, the putative mediator should be released in amounts whose local concentrations in the tissue are capable of inducing these signs; ideally its appearance should correlate with development of the inflammatory reaction.

  3. (3)

    Release or actions of the putative mediator should be reduced by known anti-inflammatory drugs and, as a corollary, drugs which reduce the release or actions of the mediator should possess anti-inflammatory properties.

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References

  • Ambache, N., 1961, Prolonged erythema produced by chromatographically purified irin, J. Physiol. (London) 160:3.

    Google Scholar 

  • Ambache, N., Brummer, M. C., Rose, S. G., and Whiting, J., 1966, Thin layer chromatography of spasmogenic unsaturated hydroxy acids from various tissues, J. Physiol. (London) 185:77.

    Google Scholar 

  • Ambache, N., Kavanagh, L., and Whiting, J., 1965, Effect of mechanical stimulation on rabbits’ eyes: release of active substances in anterior chamber perfusates, J. Physiol. (London) 176:378.

    Article  CAS  Google Scholar 

  • Anderson, A. J., 1970, Lysosomal enzyme activity in rats with adjuvant-induced arthritis, Ann. Rheum. Dis. 29:307.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Anderson, A. J., Brocklehurst, W. E., and Willis, A. L., 1971, Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin-induced inflammation in the rat. Pharm. Res. Commun. 2:13.

    Article  Google Scholar 

  • Anggard, E., and Jonsson, C. E., 1971, Efflux of prostaglandins in lymph from scalded tissue. Acta. Physiol. Scand. 81:440.

    Article  PubMed  CAS  Google Scholar 

  • Arora, S., Lahiri, P. K., and Sanyal, R. K., 1970, The role of prostaglandin E(1) in inflammatory process in the rat. Int. Arch. Allergy, 39:186.

    Article  PubMed  CAS  Google Scholar 

  • Bartels, J., Kunze, H., Vogt, W., and Wille, G., 1970, Prostaglandin liberation from and formation in trog intestine, Nuanyn-Schmiedeberg’s Arch. Pharmak. Exp. Path. 206:199.

    Article  Google Scholar 

  • Beitch, B. R., and Eakins, K. E., 1969, The effects of prostaglandins on the intraocular pressure of the rabbit, Br. J. Pharmac. 37:158.

    Article  CAS  Google Scholar 

  • Bergstrom, S., Carlsson, L. A., Ekelund, L. G., and Oro, L., 1965, Cardiovascular and metabolic response to infusions of prostaglandin E(1) and to simultaneous infusions of noradrenaline and prostaglandin E(1) in man, Acta. Physiol. Scand. 64:332.

    Article  PubMed  CAS  Google Scholar 

  • Bergstrom, S., Carlsson, L. A., and Weeks, J. P., 1968, The prostaglandins: A family of biologically active lipids, Pharmac. Rev. 20:1.

    CAS  Google Scholar 

  • Bergstrom, S., Danielsson, H., and Samuelsson, B., 1964, The enzymatic formation of prostaglandin E(2) from arachidonic acid, Biochim. Biophys. Acta. 90:207.

    Article  CAS  Google Scholar 

  • Bethel, R. A., and Eakins, K. E., 1971, Antagonism by polyphloretin phosphate of the intraocular pressure rise induced by prostaglandins and formaldehyde in the rabbit eye, Fed. Proc. 30:626.

    Google Scholar 

  • Bonta, I. L., and De Vos, C. J., 1965, Presence of a slow contraction inducing material in fluid collected from the rat paw edema induced by serotonin, Experientia, 21:34.

    Article  PubMed  CAS  Google Scholar 

  • Brittain, R. T., 1966, The intracerebral effects of noradrenaline and its modification by drugs in the mouse, J. Pharm. Pharmac. 18:621.

    Article  CAS  Google Scholar 

  • Cashin, C. H., and Heading, C. E., 1968, The assay of antipyretic drugs in mice, using intracerebral injection of pyretogenins, Br. J. Pharmac. 34:148.

    Article  CAS  Google Scholar 

  • Collier, H. O. J., 1971, Prostaglandins and aspirin, Nature (London) 232:17.

    Article  CAS  Google Scholar 

  • Coppi, G., and Bonardi, G., 1968, Effect of two nonsteroidal anti-inflammatory agents on alkaline and acid phosphatases of inflamed tissue, J. Pharm. Pharmac. 20:661.

    Article  CAS  Google Scholar 

  • Crunkhorn, P., and Willis, A. L., 1969, Actions and interactions of prostaglandins administered intradermally in rat and man, Br. J. Pharmac. 36:216.

    Google Scholar 

  • Crunkhorn, P., and Willis, A. L., 1971a, Cutaneous reactions to intradermal prostaglandins, Br. J. Pharmac. 41:49.

    Article  CAS  Google Scholar 

  • Crunkhorn, P., and Willis, A. L., 1971b, Interaction between prostaglandins E and F given intradermally in the rat, Br. J. Pharmac. 41:507.

    Article  CAS  Google Scholar 

  • DiRosa, M., Giroud, J. P., and Willoughby, D. A., 1971, Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine, J. Path. 104:15.

    Article  PubMed  Google Scholar 

  • DiRosa, M., and Willoughby, D. A., Screens for antiinflammatory drugs, J. Pharm. Pharmac. 23:297.

    Google Scholar 

  • Eisen, V., Greenbaum, L., and Lewis, G. P., 1968, Kinins and anti-inflammatory steroids, Br. J. Pharmac. 34:169.

    Article  CAS  Google Scholar 

  • Elsbach, P., 1966, Phospholipid metabolism by phagocytic cells, I. A comparison of conversion of [32P]-lysolecithin to lecithin by homogenates of rabbit polymorphonuclear leukocytes and alveolar macrophages, Biochim. Biophys. Acta 125:510.

    Article  PubMed  CAS  Google Scholar 

  • Elsbach, P., and Rizack, M. A., 1963, Acid lipase and phospholipase activity in homogenates of rabbit polymorphonuclear leukocytes, Am. J. Physiol. 205:115.

    Article  Google Scholar 

  • Feldberg, W., and Saxena, P. N., 1971, Fever produced in rabbits and cats by prostaglandin E(1) injected into the cerebral ventricles, J. Physiol. 215:23.

    Google Scholar 

  • Ferreira, S. H., Moncada, S., and Vane, J. R., 1971, Indomethacin and aspirin abolish prostaglandin release from spleen. Nature New Biology, 231:237.

    Article  PubMed  CAS  Google Scholar 

  • Fowler, S., and De Duve, C., 1969, Digestive activity of lysosomes. III. The digestion of lipids by extracts of rat liver lysosomes, J. Biol. Chem. 244:471.

    Article  PubMed  CAS  Google Scholar 

  • Gardner, D. L., 1960, Production of arthritis in the rabbit by the local injection of the mucopolysaccharide carrageenin, Ann. Rheum. Dis. 19:369.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Giroud, J. P., and Willoughby, D. A., 1970, The interrelations of complement and a prostaglandin-like substance in acute inflammation, J. Path. 101:241.

    Article  PubMed  CAS  Google Scholar 

  • Glenn, M. E., 1972, Pro-inflammatory and anti-inflammatory effects of certain prostaglandins, in “Prostaglandins in Cellular Biology and the Inflammatory Process” (B. B. Pharriss and P. W. Ramwell, eds.). Plenum Press, New York (in press).

    Google Scholar 

  • Greaves, M. W., Sondergaard, J., and McDonald-Gibson, W., 1971, Recovery of prostaglandins in human cutaneous inflammation, Br. Med. J., 2: 258.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Green, K., and Samuelsson, B., 1964, Prostaglandins and related factors: XIX, Thin layer chromatography of prostaglandins, J. Lipid. Res. 5:117.

    Article  PubMed  CAS  Google Scholar 

  • Harris, J. M., and West, G. B., 1963, Rats resistant to the dextran anaphylactoid reactions, Br. J. Pharmac. 20:550.

    CAS  Google Scholar 

  • Holmes, S. W., 1968, Concentrations of prostaglandins in the nervous system. Ph. D. Thesis in the University of London.

    Google Scholar 

  • Holmes, S. W., 1970, The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release, Br. J. Pharmac. 38:653.

    Article  CAS  Google Scholar 

  • Holmsen, H., and Day, H. J., 1970, The selectivity of the thrombin-induced platelet release reaction: subcellular localization of released and retained constituents, J. Lab. Clin. Med. 75:840.

    PubMed  CAS  Google Scholar 

  • Horton, E. W., 1963, Action of prostaglandin E(1) on tissues which respond to bradykinin, Nature (London) 200:892.

    Article  CAS  Google Scholar 

  • Juhlin, S., and Michaelsson, G., 1969, Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis, Acta. Derm-Vener. (Stockholm) 49:251.

    CAS  Google Scholar 

  • Kaley, G., and Weiner, R., 1968, Microcirculatory studies with prostaglandin E(1), in “Prostaglandin”, symposium of the Worcester Foundation for Experimental Biology, (P. W. Ramwell and J. E. Shaw, eds.), Interscience, New York, pp. 321–328.

    Google Scholar 

  • Kaley, G., and Weiner, R., 1971, Prostaglandin E(1): a potential mediator of the inflammatory response, Ann. N. Y. Acad. Sci. 180:338.

    Article  PubMed  CAS  Google Scholar 

  • Melmon, K. L., and Cline, M. J., 1967, Interaction of plasma kinins and granulocytes. Nature, (London) 213:90.

    Article  CAS  Google Scholar 

  • Michaelsson, G., 1970, Effects of antihistamines, acetylsalicylic acid and prednisone on cutaneous reactions to kallikrein and prostaglandin E(1), Acta- Derm. Vener. (Stockholm) 30:31.

    Google Scholar 

  • Milton, A. S., and Wendlandt, S., 1970, A possible role for prostaglandin E(1) as a modulator for temperature regulation in the central nervous system of the cat, J. Physiol. Lond. 202:768.

    Google Scholar 

  • Milton, A. S., and Wendlandt, S., 1971, J. Physiol. (London) 218:325.

    Google Scholar 

  • Muller-Eberhard, H. J., 1969, Complement, Ann. Rev. Biochem. 38:389.

    Google Scholar 

  • Parrat, J. R., and West, G. B., 1958, Inhibition by various substances of edema formation in the hind paw of the rat induced by 5-hydroxytryptamine, histamine, dextran, eggwhite, and compound 48/80, Br. J. Pharmac., 13:65.

    Google Scholar 

  • Piper, P. J., and Vane, J. R., 1969, Release of additional factors in anaphylaxis and its antagonism by antiinflammatory drugs. Nature (London) 225:29.

    Article  Google Scholar 

  • Samuelsson, B., 1963, Isolation and identification of prostaglandins from human seminal plasma, J. Biol. Chem. 238:3229.

    Article  PubMed  CAS  Google Scholar 

  • Selye, H., 1954, An experimental model illustrating the pathogenesis of the diseases of adaptation, J. Clin. Endocrin., 14:997.

    Article  CAS  Google Scholar 

  • Shaw, J. E., and Ramwell, P. W., 1969, Separation, identification and estimation of prostaglandins, Meth. Biochem. Analysis, 17:325.

    CAS  Google Scholar 

  • Silver, M. J., Smith, J. B., and Webster, G. R., 1971, Phospholipase activity in human platelets, Pharmacologist, 13(2):276, abs. 474.

    Google Scholar 

  • Smith, A. D., and Winkler, H., 1968, Lysosomal phospholipases A(1) and A(2) of bovine adrenal medulla, Biochem. J., 108:867.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Smith, J. B., and Willis, A. L., 1970, Formation and release of prostaglandins by platelets in response to thrombin, Br. J. Pharmac. 40:545.

    Google Scholar 

  • Smith, J. B., and Willis, A. L., 1971, Aspirin selectively inhibits prostaglandin production in human platelets, Nature New Biology, 231: 235.

    Article  PubMed  CAS  Google Scholar 

  • Smith, M. J. H., and Dawkins, P. D., 1971, Salicylate and enzymes, J. Pharm. Pharmac. 32:729.

    Google Scholar 

  • Solomon, L. M., Juhlin, L., and Kirschbaum, M. B., 1968, Prostaglandin on cutaneous vasculature, J. Invest. Derm. 51: 280.

    Article  PubMed  CAS  Google Scholar 

  • Spector, W. G., and Willoughby, D. A., 1968, The pharmacology of inflammation, English universities Press Ltd. (London).

    Google Scholar 

  • van Arman, C. G., Begany, A. J., Miller, L. M., and Pless, H. H., 1965, Some details of the inflammations caused by yeast and carrageenin, J. Pharmac. Exp. Ther. 150:328.

    Google Scholar 

  • Vane, J. R., 1964, The use of isolated organs for detecting active substances in the circulating blood, Br. J. Pharmac. Chemother. 23:360.

    Article  CAS  Google Scholar 

  • Vane, J. R., 1971, Inhibition of prostaglandin synthesis as a mechanism of action from aspirin-like drugs, Nature New Biology, 231:232.

    Article  PubMed  CAS  Google Scholar 

  • Vargaftig, B. B., and Dao, N., Pharmacology, (in press).

    Google Scholar 

  • Waite, M., Scherphof, G. L., and Van Deenen, L. L. M., 1969, Differentiation of phospholipases A in mitochondria and lysosomes of rat liver, J. Lipid Res. 10:411.

    Article  PubMed  CAS  Google Scholar 

  • Waitzman, M. B., and King, C. D., 1967, Prostaglandin influences on intraocular pressure and pupil size. Am. J. Physiol. 212:329.

    Article  PubMed  CAS  Google Scholar 

  • Weissman, G., 1967, The role of lysosomes in inflammation and disease, Ann. Rev. Med. 18:97.

    Article  Google Scholar 

  • Weissman, G., and Thomas, L., 1964, The effect of corticosteroids upon connective tissue and lysosomes, Recent Progr. Horm. Res. 20:215.

    Google Scholar 

  • Willis, A. L., 1969a, Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion, J. Pharm. Pharmac. 21:126.

    Article  CAS  Google Scholar 

  • Willis, A. L., 1969b, Release of histamine, kinin and prostaglandins during carrageenin-induced inf lairmation in the rat, in “Prostaglandins Peptides and Amines”, (P. Mantegazza and E. W. Horton, eds.), Academic Press, London. pp. 31–38.

    Google Scholar 

  • Willis, A. L., 1970, Identification of prostaglandin E(2) in rat inflammatory exudate, Pharmac. Res. Commun. 2:297.

    Article  CAS  Google Scholar 

  • Willis, A. L., 1971, Prostaglandins: their release and inter-relationship with biogenic amines. Ph. D. Thesis in the University of London.

    Google Scholar 

  • Willis, A. L., Davison, P., and Ramwell, P. W., 1972, An action of antipyretic drugs in mice through inhibition of prostaglandin synthesis in brain, in “Prostaglandins” (in press).

    Google Scholar 

  • Willoughby, D. A., Coote, E., and Turk, J. L., 1969, Complement in acute inflammation, J. Path. 97:295.

    Article  PubMed  CAS  Google Scholar 

  • Winter, C.A., Risley, E. A., and Nuss, G. V., 1962, Carrageenin-induced edema in hind paws of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med. 111:544.

    Article  PubMed  CAS  Google Scholar 

  • Winter, C. A., Risley, E. A., and Nuss, G. V., 1963, Antiinflammatory and antipyretic activities of indomethacin, 1 (p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid, J. Pharmac. Exp. Ther. 141:369.

    CAS  Google Scholar 

  • Wiseman, E. H., and Chang, Y., 1968, The role of fibrin in the inflammatory response to carrageenin, J. Pharmac. Exp. Ther. 159:206.

    CAS  Google Scholar 

  • Woodbury, D. M., 1970, Analgesic-antipyretics, antiinflammatory agents and inhibitors of uric acid synthesis, in “Pharmacological Basis of Therapeutics”, 4th edn. (L. S. Goodman and A. Gilman, eds.), The MacMillan Company, London and Toronto, pp. 314–347.

    Google Scholar 

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Author notes

  1. W. E. Brocklehurst

    Present address: Lilly Research Centre, Windlesham, Surrey, England

  2. B. Smith

    Present address: Royal College of Surgeons, London, England

Authors and Affiliations

  1. Department of Physiology, Medical School, Stanford University, Cal., USA

    A. L. Willis, P. Davison, P. W. Ramwell, W. E. Brocklehurst & B. Smith

Authors
  1. A. L. Willis
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  2. P. Davison
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  3. P. W. Ramwell
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  4. W. E. Brocklehurst
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  5. B. Smith
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Editors and Affiliations

  1. ALZA Corporation, Palo Alto, California, USA

    Peter W. Ramwell  & Bruce B. Pharriss  & 

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© 1972 Plenum Press, New York

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Willis, A.L., Davison, P., Ramwell, P.W., Brocklehurst, W.E., Smith, B. (1972). Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs. In: Ramwell, P.W., Pharriss, B.B. (eds) Prostaglandins in Cellular Biology. Alza Conference Series, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-2844-5_12

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  • DOI: https://doi.org/10.1007/978-1-4684-2844-5_12

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