Abstract
Microencapsulated enzymes and proteins in the form of artificial cells are the first form of immobilized enzymes to be tested in animals for experimental therapy (Chang, 1957, 1964, 1966, 1969b, 1972a; Chang and MacIntosh, 1964; Chang and Poznansky, 1968). This chapter and Chapter 19 will discuss research carried out in this laboratory on the therapeutic applications of artificial cells and immobilized proteins. An increasing number of other centers have become involved in seriously looking into the therapeutic applications of all types of immobilized enzymes. Their research will be discussed in detail in other chapters.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Apple, M., 1971, Hemodialysis against enzymes as a method of “gene replacement” in cases of inherited metabolic diseases, Proc. West. Pharmacol. Soc. 14: 125.
Campbell, J., and Chang, T. M. S., 1975, Enzymatic recycling of coenzymes by a multi-enzyme system immobilized within semipermeable collodion microcapsules, Biochim. Biophys. Acta 397: 101.
Campbell, J., and Chang, T. M. S., 1976, The recycling of NAD+ (free and immobilized) within semipermeable aqueous microcapsules containing a multi-enzyme system, Biochem. Biophys Res. Commun. 62: 562.
Chang, T. M. S., 1957, Hemoglobin corpuscles, Report of research project for B.Sc. Honors, McGill University.
Chang, T. M. S., 1964, Semipermeable microcapsules, Science 146: 524.
Chang, T. M. S., 1965, Semipermeable aqueous microcapsules, Ph.D. thesis, McGill University.
Chang, T. M. S., 1966, Semipermeable aqueous microcapsules (“artificial cells”): with emphasis on experiments in an extracorporeal shunt system, Trans. Amer. Soc. Artificial Internal Organs 12: 13.
Chang, T. M. S., 1969a, Asparaginase-loaded semipermeable microcapsules for mouse lymphomas, Proc. Can. Federation Biol. Sci. 12: 62.
Chang, T. M. S., 1969b, Clinical potential of enzyme technology, Sci. Tools 16: 33.
Chang, T. M. S., 1971, the in-vivo effects of semipermeable microcapsules containing L-asparaginase on 6C3HED lymphosarcoma, Nature 229: 117.
Chang, T. M. S., 1972a, Artificial Cells, Charles C. Thomas, Publisher, Springfield, Ill.
Chang, T.M.S., 1972b, Effects of local applications of microencapsulated catalase on the response of oral lesions to hydrogen peroxide in acatalasemia, J. Dental Res. 51: 319.
Chang, T. M. S., 1973a, Biomedical applications of artificial cells, Bio-Med. Eng. 8: 334.
Chang, T. M. S., 1973b, L-Asparaginase immobilized within semipermeable microcapsules: in-vitro and in-vivo stability, Enzyme 14: 95.
Chang, T. M. S., 1975, The one-shot vaccine, in: Socio-economic and Ethical Implications of Enzyme Engineering ( C.-G. Heden, ed.), International Federation of Institutes for Advanced Studies, Stockholm, Sweden.
Chang, T. M. S., 1976a, Methods in experimental therapy using immobilized enzymes, in: Immobilized Enzymes (K. Mosbach, ed.), from Methods in Enzymology Series, Academic Press, Inc., New York.
Chang, T. M. S., 1976b, Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines and biologicals, J. Bioengineering (in press).
Chang, T. M. S., and Loa, S. K., 1970, Urea removal by urease and ammonia adsorbents in the intestine, Physiologist 13: 70.
Chang, T. M. S., and MacIntosh, F. C., 1964, Semipermeable aqueous microcapsules, Pharmacologist 6: 198.
Chang, T. M. S., and Poznansky, M. J., 1968, Semipermeable microcapsules containing catalase for enzyme replacement in acatalasemic mice, Nature 218: 243.
Chang, T. M. S., Johnson, L. J., and Ransome, O., 1967, Semipermeable aqueous microcapsules: IV. Nonthrombogenic microcapsules with heparin-complexed membranes, Can. J. Physiol. Phannacol. 45: 705.
Chang, T. M. S., Pont, A., Johnson, L. J., and Malave, N., 1968, Response to intermittent extracorporeal perfusion through shunts containing semipermeable microcapsules, Trans Amer. Soc. Artificial Internal Organs 15: 163
Gregoriadis, G., and Ryman, B. E., 1972, Fate of protein-containing liposomes injected into rats: an approach to the treatment of storage diseases, Eur. J. Biochem. 24: 485.
Ihler, G. M., Glew, R. H., and Schnure, F. W., 1973, Enzyme loading of erythrocytes, Proc. Natl. Acad. Sci. U.S. 70: 2663.
Mori, T., Sata, T., Matuo, Y., Tosa, T., and Chibata, I., 1972, Preparation and characteristics of microcapsules containing asparaginase, Biotechnol. Bioeng. 14: 663.
Mori, T., Tosa, T., and Chibata, I., 1973, Enzymatic properties of microcapsules containing asparagi-nase, Biochim. Biophys. Acta 321: 653.
Poznansky, M. J., and Chang, T. M. S., 1974, Comparison of the enzyme kinetics and immunological properties of catalase immobilized by microencapsulation and catalase in free solution for enzyme replacement, Biochim. Biophys. Acta 334: 103.
Sekiguchi, W. and Kondo, A., 1966, Studies on microencapsulated hemoglobin, J. Japan. Soc. Blood Transfusion 13: 153.
Slamona, M., Saronio, C., Bartosek, I., Vecchi, A., and Mussini, E., 1974, Fibre-entrapped enzymes, in: Insolubilized Enzymes p. 189, ( M. Salmona, C. Saronio, and S. Garattini, eds.), Raven Press, New York.
Siu Chong, E. D., and Chang, T. M. S., 1974, In-vivo effects of intraperitoneally injected L-asparaginase solution and L-asparaginase immobilized within semipermeable nylon microcapsules with emphasis on blood L-asparagine, “body” L-asparaginase, and plasma L-asparagine levels, Enzyme 18: 218.
Thorne, S. R., Fiddler, M. B., and Desnick, R. J., 1975, Enzyme therapy V: in-vivo fate ot ßglucuronidase deficient mice, Pediat. Res. 9: 918.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Chang, T.M.S. (1977). Experimental Therapy Using Semipermeable Microcapsules Containing Enzymes and Other Biologically Active Material. In: Chang, T.M.S. (eds) Biomedical Applications of Immobilized Enzymes and Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2610-6_11
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2610-6_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2612-0
Online ISBN: 978-1-4684-2610-6
eBook Packages: Springer Book Archive