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Gap Junctions in Development

  • Chapter
Intercellular Communication

Abstract

Ionic coupling, a widespread mechanism for intercellular communication, is believed to be of major importance in the control of growth and of development (see reviews by Bennett, 1973; and Loewenstein, 1968, 1974a).* The passage of inorganic ions between coupled cells is relatively unrestricted, and in many cases even large molecules such as dyes (Schmidtman, 1925, quoted by Socolar, 1973; Potter et al. 1966) and compounds of metabolic significance can be exchanged (Crick, 1970; Gilula et al. 1972; Pitts, 1971; Sheridan, 1974a,b). Intercellular coupling probably occurs via a specialized region of the membrane known as a gap junction. Nexus, a term originally proposed by Dewey and Barr (1962) in their analysis of cell coupling in smooth muscle, is used synonymously by a number of authors primarily interested in the morphology of this junction (see McNutt and Weinstein, 1973), whereas other terms such as electrotonic junction and electrical synapse are favored by electrophysiologists. Simionescu et al. (1975) have recently suggested the expression macula communicans to make the name of this cell junction consonant with the Latin nomenclature for other junctions (Farquhar and Palade, 1963). Tight junction, an appellation still used by a few authors, is clearly an anachronism from a time when it was difficult to distinguish gap junctions from occluding junctions.

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Authors and Affiliations

  1. Department of Pediatrics, Stanford University School of Medicine, Stanford, California, 94305, USA

    Eva B. Griepp

  2. Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Jean-Paul Revel

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  1. Eva B. Griepp
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  2. Jean-Paul Revel
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  1. University of Puerto Rico, San Juan, Puerto Rico

    Walmor C. De Mello

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© 1977 Plenum Press, New York

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Griepp, E.B., Revel, JP. (1977). Gap Junctions in Development. In: De Mello, W.C. (eds) Intercellular Communication. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2283-2_1

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  • DOI: https://doi.org/10.1007/978-1-4684-2283-2_1

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