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Reactive Synaptogenesis in the Adult Nervous System

The Effects of Partial Deafferentation on New Synapse Formation

  • Chapter
Neuronal Recognition

Part of the book series: Current Topics in Neurobiology ((CTNB))

Abstract

In 1885 Exner suggested that the recovery of muscular contraction observed after partial transection of a motor nerve, but prior to regeneration of the damaged fibers, resulted from collateral growth of intact fibers and reinnervation of the muscle. Subsequently Edds (1950), Hoffman (1950), and others (Weddell et al., 1946; Hones et al., 1945; Weiss and Edds, 1946) demonstrated conclusively that the transection of few motor fibers could in fact result in axon collateral sprouting by the remaining undamaged fibers. This phenomenon was extended to connections between neurons when Murray and Thompson (1957) provided direct anatomical evidence for axon collateral sprouting in the partially denervated sympathetic ganglion and Liu and Chambers (1958) reported evidence for axon sprouting in the spinal cord. Over the last 20 years there has been an explosive growth of research on axon sprouting in the central nervous system. It is now clear that the phenomenon exists and can be highly selective in terms of which fibers sprout, which neurons are reinnervated, and at what ages it can be demonstrated.

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Authors and Affiliations

  1. Department of Psychobiology, University of California, Irvine, California, USA

    Carl W. Cotman & Gary S. Lynch

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  1. Carl W. Cotman
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  1. Department of Psychiatry School of Medicine, University of California, San Diego La Jolla, California, USA

    Samuel H. Barondes

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© 1976 Plenum Press, New York

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Cotman, C.W., Lynch, G.S. (1976). Reactive Synaptogenesis in the Adult Nervous System. In: Barondes, S.H. (eds) Neuronal Recognition. Current Topics in Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2205-4_3

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  • DOI: https://doi.org/10.1007/978-1-4684-2205-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2207-8

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