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Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres

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Mechanisms in Fibre Carcinogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 223))

Abstract

In 1967, the first author of this paper started intraperitoneal studies on the carcinogenicity of asbestos. Later Wagner and coworkers (1974) published their large inhalation experiment with five asbestos types and this provided the incentive to perform similar inhalation studies with man-made mineral fibres. This aim was achieved in 1983 after some years of planning and the construction of the facilities for inhalation toxicology at the Fraunhofer Institute in Hannover. It was a great disappointment that Muhle and coworkers (1987) at the new facilities could not even find a clear carcinogenic effect in the groups exposed to chrysotile or crocidolite. Even in a parallel injection study with about 109 chrysotile fibres there was no clear carcinogenic effect. In these experiments Californian chrysotile was used as a positive control following the recommendation of NIOSH. The crocidolite sample used gave an unequivocally positive result after intraperitoneal injection of a relatively low number of fibres but no significant carcinogenic effect could be detected in the inhalation study. This compares with the work of Wagner and others (1985, 1987) who also failed to reproduce the high tumour rates observed with crocidolite in their previous inhalation study.

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Author information

Authors and Affiliations

  1. Medical Institute for Environmental Hygiene, Heinrich Heine University of Düsseldorf, Auf’m Hennekamp 50, D-4000, Düsseldorf, Germany

    F. Pott, M. Roller & R. M. Rippe

  2. Fraunhofer Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Straße 1, D-3000, Hannover 61, Germany

    P.-G. Germann & B. Bellmann

Authors
  1. F. Pott
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  2. M. Roller
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  3. R. M. Rippe
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  4. P.-G. Germann
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  5. B. Bellmann
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Editor information

Editors and Affiliations

  1. Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

    Robert C. Brown  & John A. Hoskins  & 

  2. Inhalation Toxicology Research Institute, Albuquerque, New Mexico, USA

    Neil F. Johnson

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© 1991 Plenum Press, New York

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Pott, F., Roller, M., Rippe, R.M., Germann, PG., Bellmann, B. (1991). Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_48

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  • DOI: https://doi.org/10.1007/978-1-4684-1363-2_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1365-6

  • Online ISBN: 978-1-4684-1363-2

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