Abstract
Susceptibility of inbred mice to the Coronavirus, mouse hepatitis virus strain 3 (MHV-3), is dependent on host factors which are under strict genetic control (1). Fully susceptible BALB/cJ mice die with fulminant hepatitis when inoculated with 1–5 plaque forming units (PFU) of MHV-3, while fully resistant A/J mice develop no evidence of disease even when infected with 5 × 107 PFU of MHV-3. Differences in viral replication both in-vivo and in-vitro do not account for strain-dependent differences in resistance to MHV-3, and we have suggested that variation in susceptibility/resistance of inbred mice reflects defects in the host immune response to the virus (2, 3).
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Keywords
- Proliferative Response
- Fluorescence Activate Cell Sorting
- Inbred Mouse
- Plaque Form Unit
- Peritoneal eXUdate Cell
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© 1987 Plenum Press, New York
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Dindzans, V.J., Zimmerman, B., Sherker, A., Levy, G.A. (1987). Susceptibility to Mouse Hepatitis Virus Strain 3 in Balb/cJ Mice: Failure of Immune Cell Proliferation and Interleukin 2 Production. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_50
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DOI: https://doi.org/10.1007/978-1-4684-1280-2_50
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