Abstract
Recently particular attention has been paid to the compaction of a 2-m-long DNA fiber both in the interphasal nucleus and in mitotic chromosomes. At least four levels of DNA fiber compaction may be considered: (1) the level of nucleosome with DNA packing ratio 7:1 and with formation of a nucleofilament of about 100 A° in diameter (1), (2) the level of supercoil or “solenoid” with over-all DNA packing ratio 40:1 and with formation of a chromatin thread of about 300 Ao in diameter (1), (3) the scarcely known level with DNA packing ratio 40:1-1000:1 which includes chromatin tracts (2) noticeable both under the electron and the light microscope, (4) the level of mitotic chromosome with DNA packing ratio 10000:1. While the arrangement of DNA and histones in the nucleosome and supercoil is relatively well known (3), the arrangement and mechanisms involved in alteration of chromatin tracts in the scale of the entire nucleus still remain obscure (4).
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Sawicki, W. (1979). Chromatin Pattern in Situ: Dependence upon Cell Cycle, Preimplantation Development and Cellular Aging in Vitro. In: Nicolini, C.A. (eds) Chromatin Structure and Function. NATO Advanced Study Institutes Series, vol 21b. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0976-5_12
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DOI: https://doi.org/10.1007/978-1-4684-0976-5_12
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