Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?

Kiessling, Rolf; Haller, Otto

doi:10.1007/978-1-4684-0922-2_6

Rolf Kiessling⁴ &
Otto Haller⁵

41 Accesses
144 Citations

Abstract

During thelast 10 years thenumber of effector cell types active in growth inhibition or cytolysis of tumor cells has steadily increased. Although theimportance of immune T cells in tumor rejection, measured by cytolytic or cyto-static activity in vitro, is firmly established, there is an increasing amount of evidence showing that tumor resistance also could be mediated by non-T-cell-dependent mechanisms. Some of these alternatives to T-cell cytotoxicity involve tumor killing by activated macrophages (Keller, 1976) or by antibody-dependent cellular cytotoxicity (ADCC) (Perlmann et al, 1972) carried out by a variety of nonimmune effector cells. The phenomenon of natural cell-mediated immunity to be discussed in this article will add further to thecomplexity of this field. The purpose of this chapter is, however, to convince thereader that this phenomenon, although still poorly understood, is a factor which must be seriously considered when discussing immune surveillance mechanisms against tumors.

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Authors and Affiliations

Department of Tumor Biology, Karolinska Institute, S-10401, Stockholm 60, Sweden
Rolf Kiessling
Department of Immunology, Uppsala University, Box 582, S-75123, Uppsala, Sweden
Otto Haller

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University of New Mexico, Albuquerque, New Mexico, USA
Noel L. Warner
University of Alabama in Birmingham, Birmingham, Alabama, USA
Max D. Cooper
Frederick Cancer Research Center, Frederick, Maryland, USA
M. G. Hanna Jr.

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Kiessling, R., Haller, O. (1978). Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?. In: Warner, N.L., Cooper, M.D., Hanna, M.G. (eds) Contemporary Topics in Immunobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0922-2_6

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DOI: https://doi.org/10.1007/978-1-4684-0922-2_6
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