Abstract
Congenitally hypothymic, nu/nu (nude) mice have virtually displaced all other types of T-cell-deficient mice in studies on theconsequences of T-cell deficiency, thedissection of T-cell functions, and analyses of T-cell-dependent and T-cell-independent immunological phenomena in vivo. Nude mice are severely hypothymic if not totally athymic (Loor and Roelants, 1974); thesame cannot be said for theother types of T-cell-deficient mice (e.g., Mitchell, 1974). Large numbers of SPF-derived nudeā and intact, heterozygous nu/+ littermates are now available from several centers. Their usefulness has been increased further by theavailability of inbred nude mice of various genotypes (e.g., BALB/c.nu/nu CBA/H.nu/nu, C57BL/6.nu/nu, etc.).
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Mitchell, G.F. (1978). Metazoan and Protozoan Parasitic Infections in Nude Mice. In: Warner, N.L., Cooper, M.D., Hanna, M.G. (eds) Contemporary Topics in Immunobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0922-2_3
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DOI: https://doi.org/10.1007/978-1-4684-0922-2_3
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