Abstract
Along with other carcinogens of physical or chemical origin, viruses are known to be associated with and to cause tumors in a variety of experimental animals. RNA tumor viruses in particular are widespread in many species of animals, and frequently cause sarcomas or leukemia. The isolation of fowl sarcoma-leukemia virus in the early 1910s by a number of investigators marked the first successful identification of such tumor viruses (Ellermann and Bang, 1909; Rous, 1911; Fujinami and Inamoto, 1914). The cell-virus systems used for the studies of basic aspects of the pathogenesis of avian tumor viruses illustrate the progress in methodology for studying animal viruses in general. Early work in animal hosts was gradually replaced by a system using the chorioallantoic membrane of eggs (Keogh, 1938), then by tissue culture cells (Manaker and Groupé, 1956). The establishment of an assay system for Rous sarcoma virus (RSV) in tissue culture cells (Temin and Rubin, 1958) eventually led to an era of quantitative studies on the mechanism of cellular alteration by viruses.
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© 1977 Plenum Press, New York
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Hanafusa, H. (1977). Cell Transformation by RNA Tumor Viruses. In: Fraenkel-Conrat, H., Wagner, R.R. (eds) Comprehensive Virology 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0832-4_5
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