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Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors

  • Chapter
Steroid Hormone Receptors: Basic and Clinical Aspects

Part of the book series: Hormones in Health and Disease ((HHD))

Abstract

Transcription factors, such as steroid receptors, must move through the cytoplasm to the nucleus and subsequently within the nucleus in a precisely targeted manner. Experiments carried out twenty years ago in intact cells exposed to metabolic inhibitors suggested that glucocorticoid receptors (GR) that have entered the nucleus (then defined as the low speed particulate fraction of the ruptured cell) are subsequently returned to the cytoplasm in an energy-dependent cycle (Munck et al, 1972; Ishii et al, 1972). This receptor cycle has been studied in detail in the laboratory of Allan Munck (Munck and Holbrook, 1984; for review, see Orti et al, 1992), and the shuttling of steroid receptors into and out of the nucleus in intact cells has recently been directly demonstrated by Guiochon-Mantel et al (1991) and Chandran and DeFranco (1992) using immunofluorescence to visualize the receptor protein.

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Authors and Affiliations

  1. Department of Pharmacology, The University of Michigan Medical School, USA

    William B. Pratt & Lawrence C. Scherrer

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  1. William B. Pratt
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  2. Lawrence C. Scherrer
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  1. Department of Biological Sciences, Oakland University, Rochester, Michigan, 48309-4401, USA

    V. K. Moudgil

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© 1994 Birkhäuser Boston

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Pratt, W.B., Scherrer, L.C. (1994). Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors. In: Moudgil, V.K. (eds) Steroid Hormone Receptors: Basic and Clinical Aspects. Hormones in Health and Disease. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9849-7_8

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  • DOI: https://doi.org/10.1007/978-1-4615-9849-7_8

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9851-0

  • Online ISBN: 978-1-4615-9849-7

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